|
Return to Adverse
Effects
ACTIVITY:
Herbicide
(Sulfonylurea)
CAS Name:
N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-3-(2,2,2-trifluoroethoxy)-2-pyridinesulfonamide
Structure
for
Trifloxysulfuron:
| Adverse
Effects:
Anemia
Bladder
Blood
Body
Weight Decrease
Bone
CNS
Endocrine:
Testicular
Endocrine:
Thymus
Heart
Kidney
Liver
Lung
Lymph Node
Spleen |
| Environmental
Effects:
Potential
Ground Water Contaminant. |
Regulatory
Information
(only comprehensive for the US) |
| US
EPA Registered: |
Yes |
| US
EPA PC Code: |
119009
|
| US
Tolerances: |
CFR
180.591 |
Registered
use in
(includes only a limited list of countries)
|
US
Note:
Australia - pending |
US
Maximum Residue Levels permitted
in food commodities
|
almond;
almond, hulls; fruit, citrus, group 10 (including: grapefruit,
lemon, lime, mandarin, orange, tangelo, tangerine); cotton,
undelinted seed; cotton, gin byproducts; sugarcane; and tomato. |
| Other
Information |
| Molecular
Formula: |
C14H13F3N5O6SNa |
| Entry
Year: |
1999 |
| Inventing
Company: |
Novartis |
| Manufacturers: |
Syngenta
|
| Other
Names: |
Brawn
Evoke
CGA-279202 WG
CGA-279202 Technical
CGA-279202 WG Turf
CGA 292230
CGA 362622
Monument 75 WG |
| Of
special interest: |
| PAN
Data |
| Material
Safety Data Sheets & Labels |
| May
24, 2004 - Summary
of Toxicological Data, California EPA |
| August
2002 -
Evaluation of the new
active Trifloxysulfuron-sodium in the product ENVOKE HERBICIDE.
Public Release Summary. National Registration
Authority for Agricultural and Veterinary Chemicals 2002 ISSN1443-1335. |
2003
-
US EPA 2003 work plan
for registration of 19 conventional pesticides;
6 of the 19 are fluorinated. They are Butafenacil,
Flonicamid, Flufenpyr-ethyl, Noviflumuron, Quinoxyfen,
Herbicide: Trifloxysulfuron
Uses: Almond,
Citrus, Cotton, Sugarcane, Tomato, Turf
Registrant:
Syngenta
Comments: Methyl
Bromide Alternative (tomatoes only); Electronic Data Submission |
| August
6, 2002 - Trifloxysulfuron-sodium
- Evoke Herbicide. Australia NRA Gazette
(page 24) |
| August
6, 2002 -
NOTICE Trifloxysulfuron-Sodium.
Commonwealth of Australia Gazette (page
27). Agricultural and Veterinary Chemicals Code Act 1994. |
| October
2001 - "Brawn-a 'new generation' sulfonylurea herbicide
also known as CGA-362622 or trifloxysulfuron-received Methyl
Bromide Alternative status for use on tomatoes, making this
active ingredient eligible for accelerated review at the Environmental
Protection Agency. According to Greg Watson, Herbicides Team
Leader in the Syngenta Crop Protection Regulatory Affairs group,
EPA granted this status primarily due to Brawn's excellent safety
profile and excellent performance on sedges in tomato crops."
Ref:
Manatee Vegetable Newsletter
September/October 2001 |
| June
2001 - Trial use on cotton in the US.
2000 Cotton Research Report
No. 19. Alabama Agricultural Experiment
Station, Auburn University, Auburn, Alabama. |
| See
also
Trifloxysulfuron |
US
Federal Register
••
Note: Due to length, the following is a partial
list. Click
here to see full list of FR entries.
|
| Date
Published |
Docket
Identification Number |
Details |
| April 13, 2007 |
EPA-HQ-OPP-2007-0005 |
Notice
of Receipt of Requests to Voluntarily Cancel Certain Pesticide
Registrations.
| Registration No. |
Product Name |
Registrant |
| 000100 TX-06-0019 |
Envoke Herbicide |
Syngenta Crop
Protection, Inc.
Po Box 18300
Greensboro NC 274198300 |
|
| Sept
17, 2003 |
OPP-2003-0286 |
| SYNGENTA:
Pesticide
tolerances. FINAL RULE. |
| Commodity |
Final
Tolerance
PPM |
Commodity |
Tolerances
originally requested by Syngenta
PPM |
|
sugarcane |
0.01 |
sugarcane |
0.01 |
| Cotton,
undelinted seed |
0.05 |
cottonseed |
0.05 |
| Cotton,
gin byproducts |
1.0 |
cotton
byproducts |
1.0 |
| Fruit,
citrus, Group 10
*see
below for fruits in this category |
0.03 |
citrus |
0.01 |
| almond
hulls |
0.01 |
- |
- |
| almond
|
0.02 |
almond
nut meat |
0.01 |
| tomatoe |
0.01 |
tomatoes |
0.01 |
| Fruit,
citrus, Group 10 includes - Ref: http://cfpub.epa.gov/oppref/food_feed/index.cfm |
| calamondin |
citrus,
oil |
lemon
|
orange,
sour, juice |
| citron,
citrus |
fruit
|
lemon,
dried pulp |
orange,
sour, oil |
| citrus |
fruit,
citrus |
lemon,
juice |
orange,
sweet |
| citrus
hybrids |
fruit,
citrus, dried pulp |
lemon,
oil |
orange,
sweet, dried pulp |
| citrus
hybrids, dried pulp |
fruit,
citrus, except mandarin |
lime |
orange,
sweet, juice |
| citrus
hybrids, juice |
fruit,
citrus, postharvest |
lime,
dried pulp |
orange,
sweet, oil |
| citrus
hybrids, oil |
grapefruit
|
lime,
juice |
pummelo |
| citrus,
dried pulp |
grapefruit,
dried pulp |
lime,
oil |
tangelo |
| citrus,
juice |
grapefruit,
juice |
mandarin,
satsuma |
tangerine |
| citrus,
meal |
grapefruit,
oil |
orange,
sour |
-- |
| citrus,
molasses |
kumquat |
orange,
sour, dried pulp |
| Some
excerpts from Table 1.-- Subchronic, Chronic, and Other
Toxicity |
| Sudy
Type and -[Guideline No.] |
Results |
| 90-Day
oral toxicity rodents (rats) - [870.3100] |
NOAEL: 507/549 milligrams/kilogram/day (mg/ kg/day) Male/Female
(M/F) LOAEL: 1052/1128 mg/kg/day (M/F):
M = decreased
body weight, decreased body weight gain, equivocal
increased testicular atrophy at end of recovery
phase;
F = decreased
body weight, decreased body weight gain, equivocal
slightly increased histopathology in liver
(single cell necrosis, focal necrosis, inflammation, hepatocellular
hypertrophy). |
|
90-Day oral toxicity rodents (mice)
- [870.3100] |
NOAEL:
1,023/1,507 mg/kg/day (M/F) LOAEL: >1,023/>1,507 mg/kg/day
(M/F):
M = not attained;
F = not attained. |
|
90-Day oral toxicity in nonrodents (dogs)
- [870.3150] |
NOAEL:
19.8/19.6 mg/kg/day (M/F) LOAEL: 164.2/167.3 mg/kg/day
(M/F):
M = decreased
body weight gain (20%), slight hematological effects,
clinical chemistry changes suggesting
hepatotoxicity, decreased thymus
weight, thymic atrophy, increased
glycogen in liver, hemorrhage
in mesenteric lymph nodes;
F = decreased
body weight gain (44%), anemia
with extramedullary hematopoiesis in
liver/ spleen and myeloidhyperplasia in bone
marrow, clinical chemistry changes suggesting hepatotoxicity,
decrease thymus weight,
thymic atrophy and hyaline tubular change in kidney. |
| 21/28-Day
dermal toxicity (rats) - [870.3200] |
NOAEL: 1,000/100 mg/kg/day (M/F) LOAEL: >1,000/1,000 mg/kg/day(M/F):
M = not attained;
F = decreased
body weight gain. No dermal irritation M/F. |
| Prenatal
developmental in rodents (rats)
- [870.3700] |
Maternal
NOAEL: 300 mg/kg/day Maternal LOAEL: 1,000 mg/kg/day based
on decreased food consumption during treatment, decreased
body weight gain during post-treatment. Developmental
NOAEL: 300 mg/kg/day Developmental LOAEL: 1,000 mg/kg/day
based on slight decrease in fetal
weight, increased skeletal
anomalies, increased poor/absent
skeletal ossification. |
| Prenatal
developmental in nonrodents (rabbit)
- [870.3700] |
Maternal
NOAEL: 100 mg/kg/day Maternal LOAEL: 250 mg/kg/day based
on increased mortality, increased
vaginal/ anal bleeding. Developmental NOAEL: 50 mg/kg/day
Developmental LOAEL: 100 mg/kg/day based on abnormally
shaped heart (one fetus at 100 mg/kg/day and 3
fetuses from 2 litters at 250 mg/kg/day).
-- In historical control data provided
by the registrant, there were no reported instances of
abnormally shaped hearts. |
| Reproduction
and fertility effects (rat) - [870.3800] |
Parental
systemic NOAEL: 78.8/83.5 mg/kg/ day
(M/F) Parental systemic LOAEL: 631/676 mg/kg/day (M/F)
based on decreased body weight
and gain as well as decreased food consumption.
Offspring systemic NOAEL: 78.8/83.5 mg/kg/ day (M/F) Offspring
systemic LOAEL: 631/676 mg/kg/day (M/F): decreased
pup weight and weight gain, decreased spleen
weight, thymus weight and
increased vaginal patency.
Reproductive NOAEL: 968/1,030 mg/kg/day (M/ F) Reproductive
LOAEL: >968/1,030 (M/F) |
| Chronic
toxicity rodents
(rat) - [870.4100]
Chronic
feeding/ carcinogenicity
rats - [870.4300]
Carcinogenicity
rats -
[870.4200] |
NOAEL: 82.6/23.7 mg/kg/day (M/F) LOAEL: 429/99.3 mg/kg/day
(M/F):
M = decreased
body weight and gains, decreased food consumption
and increased Leydig cell hyperplasia
in testes;
F = increased tubular atrophy
in kidneys. At 500 mg/kg/
day decreased body weight,
body weight gain, food consumption and increased tubular
atrophy in kidneys. Negative
for carcinogenicity in M and F. |
Carcinogenicity
mice - [870.4200] |
NOAEL:
854/112 mg/kg/day (M/F) LOAEL: >854/818 mg/kg/day (M/F):
M = not determined;
F = decreased
body weight,
body weight gain and food consumption.
Negative for carcinogenicity in M and F. |
Chronic
toxicity
dogs - [870.4100] |
NOAEL: 51.1/45.3 mg/kg/day (M/F) LOAEL: 123/121 mg/kg/day
(M/F):
M = gray- white foci in lungs,
fibrous thickening of lung
pleura, equivocal decreased body
weight gain;
F = equivocal increased incidence
and severity of chronic urinary
bladder inflammation. |
In
vitro unscheduled DNA synthesis (primary rat hepatocytes)
- [870.5500] |
Negative
response up to 250 [mu]g/mL. Cytotoxicity
at £=15.63 [mu]g/ mL. |
| Acute
neurotoxicity screening battery (rat)
- [870.6200] |
NOAEL:
<2,000 mg/kg/day (M/F) LOAEL: 2,000 mg/kg/day (M/F):
M and F = decreased motor activity on day 1, histopathological
lesions in nervous system tissues. |
|
Subchronic neurotoxicity screening battery (rat)
- [870.6200 ] |
NOAEL:
112/553 mg/kg/day (M/F) LOAEL: 472/1,128 mg/kg/day (M/F):
M = decreased
body weight, body weight gain and food consumption.;
F = decreased
body weight. |
--
Trifloxysulfuron will be registered
for use on the following non-dietary sites: Turf--golfcourses.
-- A developmental neurotoxicity study in rats is not required. |
••
Note: Due to length, the above is a partial list.
Click here
to see full list of FR entries.
|
June
8, 2001 - Syngenta
AG.
Form 20-F. US Securities and Exchange
Commission.
"Divestments.
Novartis, AstraZeneca and Syngenta made several divestments
in order to satisfy conditions imposed by the FTC and
the European Commission in connection with the formation
of Syngenta. The divestments completed in 2000 included
the sale of the acetochlor based herbicide products to
Dow AgroSciences LLC and the selling of the strobilurin
fungicide product line FLINT®
to Bayer AG.
The divestments completed in 2001
include the sales of the grass herbicide propaquizafop
and the pyrethroid insecticide
tau-fluvalinate to
Makhteshim Agan Industries Ltd,
the sale of its sulcotrione herbicide MIKADO ® in
the European Economic Area to Bayer AG,
the divestment of its global
flutriafol fungicide business to
Cheminova A/S and
the divestment to Makhteshim Agan Ltd. of its former Novartis
cereal fungicide product range in Denmark, Sweden and
Finland (p 9)."... Active
Substances. Herbicides:
Fluthiacet, Butafenacil,
Mesotrione, Pyriftalid, Trifloxysulfuron-sodium.
Fungicides: Picoxystrobin.
Insecticides: Nemathorin.
Recently Launched Products: Herbicide:
S-metolachlor (Dual Magnu, Dual Gold, Bicep
Magnum). Fungicides:
Metalaxyl-M (Ripomil, Gold, Apron XL) Acibenzolar-S-Methyl
(Bion, Boost, Actigard), Azoxystrobin (Amistar, Quadris,
Heritage, Abound). Insecticides: Thiamethoxam, Emamectin
Benzoate, Pymetrozine. Key Marketed Products: Metolachlor
(Dual, Bicep), Atrazine (Aatex, Gesaprim), Clodinafop
(Topik, Horizon, Celio,
Banvel, Mondak, Clarity), Triasulfuron (Logran, Amber),
Trinexapa (Moddeus, Primo), Flauzifop-P-Butyl
(Fusilade), Fomesafen
(Flex, Reflex), Molinate (Ordram),
Tralkoxydim (Achieve, Grasp). Non-selective herbicides:
Paraquat (Gramoxone), Sulfosate (Touchdown, Zapp, Ouragan),
Diquat (Reglone). Fungicides: Metalaxyl (Ridomil, Apron),
Propiconazole (Tilt), Difenoconazole (Score, Dividend),
Fludioxonil (Celest,
Maxim, Geoxe, Medallion), Cyprodnil (Unix, Stereo, (5)
Switch), Cyrpoconazole (Alto), Chlorothalonil (Bravo,
Daconil), Fluazinam
(Shirlan). Insecticides: Abamectin
(Vertimec, Agrimek), Profenofos (Curacron, Selectron),
Methidathion (Supracide), Lufenuron
(Match),
Lambda-cyhalothrin (Karate,
Kung-Fu, Icon), Tefluthrin
(Force). Products in Development:
Fluthiacet (licensed
from Kumiai, Inc.), Butafenacil,
Pyriftalid, Trifloxysulfuron-sodium,
Mesotrione, Recently launced products:
Dual Gold and Dual Magnum. Key marketed products: Dual®
and Bicep®, our eading corn grass herbicides, are
currently being replaced by Dual Gold®, Dual Magnum®
and Bicep Magnum®...
Nature of operations. Syngenta AG
is a world leading crop protection and seeds business
that is involved in the discovery, development, manufacture
and marketing of a range of agricultural products designed
to improve crop yields and food quality. Syngenta is headquartered
in Basel, Switzerland and was formed by Novartis AG ("Novartis")
and AstraZeneca PLC ("AstraZeneca") through
an agreement to spin off and merge the Novartis crop protection
and seeds businesses with the Zeneca agrochemicals business
to create a dedicated agribusiness company whose shares
were then the subject of a global offering (the "Transactions").
The Transactions were completed on November 13, 2000 (the
"Transaction Date"). In this annual report,
for periods prior to November 13, 2000, we refer to the
businesses contributed by Novartis as the "Novartis
agribusiness"; and we refer to the businesses contributed
to Syngenta by AstraZeneca as the "Zeneca agrochemicals
business" (p i)."
Note:Fluorinated
pesticides highlighted in red
|
May
9, 2000 - Novartis:
Form
20-F/A. US Securities & Exhange Commission.
New products in development: Butafenacil,
Clodinafop, Fludioxonil (Apron), Fluthiacet,
Metolachlor, Trifloxystrobin,
Trifloxysulfuron.
Note: "The Company was created
by the merger of Sandoz AG and CIBA-Geigy AG (the "Merger")
in December 1996. Prior to the Merger, Sandoz AG
and CIBA-Geigy AG were each global participants in the
pharmaceutical and agrochemical industries. The predecessor
companies of the Company merged to realize sales, cost
and cross-sector synergies, and to create a combined entity
with the resources and ability to compete in the long
term in an increasingly competitive global environment.
The Boards of the Company and AstraZeneca announced on
December 2, 1999, that they each agreed to spin off and
merge Novartis Crop Protection and Seeds businesses and
Zeneca Agrochemicals to create the world's first dedicated
agribusiness company with pro forma combined sales in
1998 of approximately $7.9 billion. The new company will
be named Syngenta AG ("Syngenta"), headquartered
in Basel, Switzerland (p 5)...
In Crop Protection, the major production
sites for the active ingredients are located in India,
Switzerland, the UK and the U.S., with the major production
sites for formulation and packaging in Brazil, China,
France, South Korea, Switzerland and the U.S. (p 36)...
Agribusiness. On September
1, 1998, Novartis acquired a production plant and related
operating assets from Oriental Chemicals Industries, South
Korea for CHF 196 million (p F-13)."
Note: Fluorinated pesticides highlighted
in red
|
|
