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Sulfluramid (4151-50-2). Hazardous Substances Data Bank.
From the Hazardous Substances Data Bank. Online as of October 22, 2003
SULFLURAMID
CASRN: 4151-50-2
For other data, click on the Table of ContentsHuman Health Effects:
Skin, Eye and Respiratory Irritations:
Harmful if absorbed through skin. Avoid contact with skin, eyes or clothing. /FirstLine GT Plus product label/
Probable Routes of Human Exposure:
Occupational exposure to sulfluramid may occur through inhalation and dermal contact with this compound at workplaces where sulfluramid is produced or used. (SRC)
Emergency Medical Treatment:
Antidote and Emergency Treatment:
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/
Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/
Animal Toxicity Studies:
Non-Human Toxicity Excerpts:
/LABORATORY ANIMALS: Acute Exposure/ Primary Eye Irritation-Rabbits: Not considered an eye irritant; Primary Dermal Irritation-Rabbits: Mild skin irritant. Score of 0.13.
/GENOTOXICITY/ Salmonella Mammalian Activation Gene Mutation Assay: Negative up to the limits of solubility (624 ug/plate and above) and dosing (tested up to 10,000 ug/plate. Sister Chromatid Exchange in Chinese Hamster Ovary Cells: Negative for inducing sister chromatid exchange in vitro.
Non-Human Toxicity Values:
LD50 Rat oral 543 mg/kg
LD50 Rabbit dermal > 2000 mg/kg /Conditions of bioassay not specified/
LD50 Rat oral 500 mg/kg /Conditions of bioassay not specified/
LD50 Rat dermal 1250mg/kg
Ecotoxicity Values:
LC50 Rainbow trout (Oncorhynchus mykiss) >2 ppm/96 hr /Conditions of bioassay not specified/
LD50 Bobwhite quail oral 473 mg/kg
LC50 Mallard duck (dietary) 165 ppm
LC50 Bobwhite quail (dietary) 460 ppm
LD50 Bobwhite quail oral 473 mg/kg
Metabolism/Pharmacokinetics:
Pharmacology:
Environmental Fate & Exposure:
Evironmental Fate/Exposure Summary:
Sulfluramid's production may result in its release to the environment through various waste streams; it's use as an insecticide will result in its direct release to the environment. If released to air, a vapor pressure of 4.28X10-7 mm Hg at 25 deg C indicates sulfluramid will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase sulfluramid will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 2 days. Particulate-phase sulfluramid will be removed from the atmosphere by wet and dry deposition. As a class, fluorinated organic compounds are resistant to photolysis. If released to soil, sulfluramid is expected to have no mobility based upon an estimated Koc of 3.5X10+6. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 5.4 atm-cu m/mole. However, adsorption to soil is expected to attenuate volatilization. As a class, fluorinated organic compounds are resistant to microbial degradation. If released into water, sulfluramid is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 107 years if adsorption is considered. An estimated BCF of 500 suggests the potential for bioconcentration in aquatic organisms is high. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to sulfluramid may occur through inhalation and dermal contact with this compound at workplaces where sulfluramid is produced or used. (SRC)
Probable Routes of Human Exposure:
Occupational exposure to sulfluramid may occur through inhalation and dermal contact with this compound at workplaces where sulfluramid is produced or used. (SRC)
Artificial Pollution Sources:
Sulfluramid's production may result in its release to the environment through various waste streams; it's use as an insecticide(1) will result in its direct release to the environment(SRC).
Environmental Fate:
TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 3.5X10+6(SRC), determined from a structure estimation method(2), indicates that sulfluramid is expected to be immobile in soil(SRC). Volatilization of sulfluramid from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.4 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Sulfluramid is not expected to volatilize from dry soil surfaces(SRC) based upon vapor pressure of 4.28X10-7 mm Hg(4). However, adsorption to soil is expected to attenuate volatilization(SRC). As a class, fluorinated organic compounds are resistant to hydrolysis and microbial degradation(5).
AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 3.5X10+6(SRC), determined from a structure estimation method(2), indicates that sulfluramid is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 5.4 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated volatilization half-lives for a model river and model lake are 7 hrs and 9 days, respectively. However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 107 years if adsorption is considered(5). The pKa of sulfluramid is 9.50(6), indicating that this compound will partially exist in the ionized form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts(7). According to a classification scheme(8), an estimated BCF of 500(SRC), from an estimated log Kow of 8.5(9) and a regression-derived equation(10), suggests the potential for bioconcentration in aquatic organisms is high(SRC). As a class, fluorinated organic compounds are resistant to hydrolysis and microbial degradation(11).
ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), sulfluramid, which has a vapor pressure of 4.3X10-7 mm Hg at 25 deg C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase sulfluramid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2 days(SRC), calculated from its rate constant of 8.8X10-12 cu cm/molecule-sec at 25 deg C(SRC) that was derived using a structure estimation method(3). Particulate-phase sulfluramid may be removed from the air by wet and dry deposition(SRC). As a class, fluorinated organic compounds are resistant to photolysis(4).
Environmental Biodegradation:
As a class, fluorinated organic compounds are resistant to microbial degradation(1).
Environmental Abiotic Degradation:
The rate constant for the vapor-phase reaction of sulfluramid with photochemically-produced hydroxyl radicals has been estimated as 8.8X10-12 cu cm/molecule-sec at 25 deg C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 2 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). As a class, fluorinated organic compounds are resistant to hydrolysis and photolysis(2).
Environmental Bioconcentration:
An estimated BCF of 500 was calculated for sulfluramid(SRC), using an estimated log Kow of 8.5(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC).
Soil Adsorption/Mobility:
Using a structure estimation method based on molecular connectivity indices(1), the Koc for sulfluramid can be estimated to be 3.5X10+6(SRC). According to a classification scheme(2), this estimated Koc value suggests that sulfluramid is expected to be immobile in soil. The pKa of sulfluramid is 9.50(3), indicating that this compound will partially exist in the ionized form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts(4).
Volatilization from Water/Soil:
The Henry's Law constant for sulfluramid is estimated as 5.4 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that sulfluramid is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 7 hrs hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 9 days(SRC). However, adsorption is expected to attenuate volatilization. The pKa of sulfluramid is 9.50(4), indicating that this compound will partially exist in the ionized form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts(5). The volatilization half-life from a model pond is about 107 years when adsorption is considered(3). Sulfluramid's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Sulfluramid is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 4.28X10-7 mm Hg(4).
Environmental Standards & Regulations:
FIFRA Requirements:
New Active Ingredients ... includes pesticide active ingredients initially registered after November 1, 1984, that currently have active product registrations. By law, these newer pesticides are not subject to the reregistration program. They must, however, meet the new safety standard of the FQPA, and will be reviewed on a 15-year cycle under the registration review program. ... Active Ingredient Number: 128992; Type of Pesticide: Conventional-insecticide; Use Site: Greenhouse ornamental/non-food areas; Year: 1989.
TSCA Requirements:
Certain Perfluoroalkyl Sulfonates. Chemical substances and significant new uses subject to reporting. 1-Octanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro- is included on this list.
Chemical/Physical Properties:
Molecular Formula:
C10-H6-F17-N-O2-S
Molecular Weight:
527.2
Color/Form:
Colorless crystals
Boiling Point:
196 deg C
Melting Point:
96 deg C
Dissociation Constants:
pKa= 9.50
Octanol/Water Partition Coefficient:
log Kow greater than 6.80
pH:
Very weak acid
Solubilities:
Solubility in dichloromethane 18.6, hexane 1.4, methanol 833 (all in g/l)
Insoluble in water @ 25 deg C
Vapor Pressure:
4.28X10-7 mm Hg @ 25 deg C
Other Chemical/Physical Properties:
MP: 87-93 deg C /Technical/
Chemical Safety & Handling:
Skin, Eye and Respiratory Irritations:
Harmful if absorbed through skin. Avoid contact with skin, eyes or clothing. /FirstLine GT Plus product label/
Fire Fighting Procedures:
For small fires, use chemical powder, CO2
Protective Equipment & Clothing:
Pants, long-sleeved shirt, gloves, helmet, boots, and face protector such as a full face shield with goggles.
Preventive Measures:
If on skin: Wash with plenty of soap and water. Get medical attention. /FirstLine GT Plus product label/
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
Stability/Shelf Life:
Stable >90 days at 50 deg C; to light >90 days in closed jar
Storage Conditions:
Store in original containers only. Store in a cool dry place and avoid excess heat. /FirstLine GT Plus product label/
Cleanup Methods:
In case of spill, avoid contact, isolate area and keep out animals and unprotected persons. Confine spills. ... To confine spill: Cover to prevent dispersal. Place damaged package in a holding container. Identify contents. /FirstLine GT Plus product label/
Disposal Methods:
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Occupational Exposure Standards:
Manufacturing/Use Information:
Major Uses:
Used for household control of Formicidae and Blattellidae.
Insecticide
For sulfluramid (USEPA/OPP Pesticide Code: 128992) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./
Formulations/Preparations:
Principal tradename: Finitron (Griffin).
Laboratory Methods:
Special References:
Synonyms and Identifiers:
Synonyms:
AI3-29757
**PEER REVIEWED**
Alstar
**PEER REVIEWED**
BRN 2317462
**PEER REVIEWED**
EINECS 223-980-3
**PEER REVIEWED**
USEPA/OPP Pesticide Code: 128992
**PEER REVIEWED**
N-Ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-1-octanesulfonamide
**PEER REVIEWED**
N-Ethylheptadecafluorooctanesulphonamide
**PEER REVIEWED**
N-Ethylperfluorooctanesulfonamide
**PEER REVIEWED**
N-ethylperfluoro-octane-1-sulfonamide
**PEER REVIEWED**
N-Ethylperfluorooctylsulfonamide
**PEER REVIEWED**
Finitron
**PEER REVIEWED**
GX 071
**PEER REVIEWED**
1-Octanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-
**PEER REVIEWED**
Formulations/Preparations:
Principal tradename: Finitron (Griffin).
Administrative Information:
Hazardous Substances Databank Number: 7100
Last Revision Date: 20031015
Last Review Date: Reviewed by SRP on 05/29/2003
Update History:
Complete Update on 2003-10-15, 37 fields added/edited/deleted
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Record Length: 17765.0