Methanesulfonyl fluoride
CAS No. 558-25-8

 
 

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ACTIVITY: Fumigant, Insecticide, Wood Preservative

Note: Organophosphate pesticide - no longer being used

Structure:

Adverse Effects:

Ataxia
Blood
Brain
CNS - Irreversible inhibitor of acetylcholinesterase
Tremors/Convulsions

Regulatory Information
(only comprehensive for the US)
US EPA Registered: No 
Other Information
Molecular Formula: CH3 F O2S 
Manufacturers: Bayer AG 
Other Names: 4-04-00-00027 (Beilstein Handbook Reference)
BRN 1740836
EINECS 209-192-2
Fluoro methyl sulfone
Fumette
HSDB 6397
MSF
Mesyl fluoride
Methanesulphonyl fluoride
 
Of special interest:
TOXNET profile from Hazardous Substances Data Base 
2001 - Used in the treatment of dementia of the Alzheimer's type. Layton Biosciences.
Included on The List of Extremely Hazardous Substances US 40 CFR - CHAPTER I - PART 355 - updated October 3, 2003 

Note from FAN: If you have any of the documents listed below, please share them with us. Thanks. EC.

New Chemicals Markedly Inhibit Cholinesterase.

Authors: Anon

Author Address: National Institutes of Health, Bethesda, MD.

Source: Govt Reports Announcements & Index (GRA&I), Issue 23, 1986

Abstract: TD3: This citation summarizes a one-page announcement of technology available for utilization. Chemicals that markedly inhibit the enzyme cholinesterase (ChE) in the rat brain but relatively little in other tissues have been discovered by Dr. Donald E. Moss and his colleagues at the University of Texas at EL Paso (UTEP). Dr. Moss and his colleagues found that phenylmethanesulfonyl fluoride (PMSF) and methanesulfonyl fluoride (MSF) inhibited 90 percent of ChE activity in the rat brain but less than 35 percent in other tissues. The enzyme hydrolyzes acetylcholine, a vital neurotransmitter. Acetylcholine is markedly deficient in the brains of patients with Alzheimer disease, due at least in part to decreased synthesis, Dr. Moss points out. 'A therapeutic strategy, therefore, would be to cut down ChE's destructive action so that the little bit of neurotransmitter that is being synthesized lasts longer,' he says. Dr. Moss points out that a big advantage of MSF and PMSF over other drugs is their apparent l

Keywords:
Cholinesterase inhibitors
Enzyme inhibitors
Phenylmethanesulfonyl fluoride
Methanesulfonyl fluoride

Order Number: NTIS/NTN86-0746, FOR ADDITIONAL INFORMATION: Contact: Research Resources Information Center, 1601 Research Blvd, Rockville, MD; (301)984-2870, Refer to X, No. 1., 1p

Price: NTIS Prices: Not available NTIS Supporting Agency: Department of Health and Human Services, Washington, DC.

INITIAL SUBMISSION: TOXICITY STUDIES WITH METHANESULFONYL FLUORIDE IN MICE AND GUINEA PIGS WITH COVER LETTER DATED 08-11-92

Source: EPA/OTS; Doc #88-920005177

Keywords:
EASTMAN KODAK CO
METHANESULFONYL FLUORIDE
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
MICE ORAL
GUINEA PIGS
DERMAL CAS

Registry Numbers: 558-25-8

Order Number: NTIS/OTS0544151

Methanesulfonyl fluoride

Authors: ANON

Source: In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington, D.C. 20460, USA, Dec. 1985. 3p.

Abstract: Chemical safety information sheet. Highly toxic when inhaled. When heated to decomposition, it emits toxic fumes of fluorides and sulfur oxides. No other information available.

Keywords:
USA
METHANESULFONYL FLUORIDE
DATA SHEET
HEALTH HAZARDS
CHEMICAL HAZARDS
PERSONAL PROTECTIVE EQUIPMENT
WASTE DISPOSAL
ILO CAS

Registry Numbers: 558-25-8

Types: MONOGRAPH

 
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