Adverse Effects:

Anemia
Ataxia
Blood
Body Weight Decrease
Bone
Brain
CNS
Cytotoxic
Developmental
Endocrine: Thymus
Heart
Kidney
Liver
Lung
Spleen
Tremors

Environmental Effects:

Moderately to Very High Toxic to freshwater and estuarine/marine fish and invertebrates

Risks to Bees: High Toxicities via contact routes

Australia, India, New Zealand, US
Africa: Burkina Faso, Cameroon, Cape Verde, Chad, Gambia, Guinea-Bissau, Mali, Mauritania, Niger, Senegal, South Africa, Taiwan, Tanzania 

Indoxacarb and its R-enantimomer are permitted in or on 67 food commodities, including:
Apple, Brassica, Cattle, Corn,
Cotton gin byproducts,
Cotton, undelinted seed,
Goat, Hog, Horse,
Lettuce (head & leaf),
Milk, Milk fat, Pear, Sheep,
Vegetables (fruiting group)

Experimental Use Permit:
Cherry (sweet & tart) to May 2007
Peaches from May 2003 to May 2006
Time-limited tolerances:
Collards to June 2006
Cranberry to Dec 2007

US:
DuPont, Alabama 36505 

Asturias, Spain

June 8, 2005 - Multi-national giant DuPont is planning to enter India's infrastructure industry in a big way besides expanding its agriculture seed and coating and colour technologies business in the country, its chief executive said on Wednesday. "India has been our traditional base where we have been trying to enter the coating technology market in a big way. Now, the infrastructure sector was opening up and we would also be keen to register our presence," DuPont chairman and chief executive officer Chad Holliday told PTI Nagoya, Japan.... Later briefing visiting reporters, Holliday said DuPont's market in China was around $1 billion. Referring to the company's achievements in the agricultural seed sector, Holliday recalled that Indian farmers were amazed at the results on utilising Indoxcarb, a branded cotton insecticide. "Similarly in Argentina we helped farmers fight Asian Soyabean Rust, a devastating new disease with our best-in-class fungicide Flusilazole," company vice-president Uma Chowdhry told PTI. Powell said the company earned 42 per cent of its revenue from USA, 28 per cent from Europe and 17 per cent from Asia.
Ref: DuPont eyes India's core sector; by Priyadarshi Siddhanta in Nagoya | June 08. rediff.com

June 9, 2005 - Production in Gujarat. India, Mr Holliday, said, presented a huge market in agriculture protection and insecticides. In particular, the chemical insecticide (Indoxacarb) for cotton sold under the brand name DuPont Avaunt has done exceedingly well. The company has a production centre at Savli in Gujarat where it has two units for some other crop protection products. In the same area, DuPont has one for liquid packaging systems and for its `Refinish' blending facility.
Ref: DuPont goes where the market is, says CEO by Ashok Dasgupta, The Hindu.

Indoxacarb
METHYL 7-CHLORO-2,5-DIHYDRO-2-
{{(METHOXYCARBONYL){4-
(TRIFLUOROMETHOXY)PHENYL}AMINO}
CARBONYL}-
INDENO{1,2-E}{1,3,4}OXADIAZINE-4A(3H)-
CARBOXYLATE

California Index Name:
INDENO{1,2-E}{1,3,4}OXADIAZINE-4A(3H)-
CARBOXYLIC ACID, 7-CHLORO-2,5-
DIHYDRO-2-{{(METHOXYCARBONYL){4-
(TRIFLUOROMETHOXY)PHENYL}AMINO}
CARBONYL}-, METHYL ESTER, (S)- (9CI)

E.I. du Pont de Nemours and Company and IR4. Pesticide tolerance. FINAL RULE.
Tolerances are established for the combined residues of the insecticide indoxacarb and its R-enantiomer, (R)- methyl 7-chloro-2,5-dihydro-2[[(methoxycarbonyl)[4(trifluoromethoxy)phenyl]amino]carbonyl]indeno[1,2-e][1,3,4][oxadiazine-4a(3H)-carboxylate, in or on the following raw agricultural commodities:

This group includes 19 commodities.
balsam apple • balsam pear • cantaloupe • chayote, fruit • cucumber • cucumber, chinese • cucurbits • gherkin, west indian • gourd, edible • melon • melon, citron • muskmelon • pumpkin • squash • squash, summer • squash, winter • vegetable, cucurbit, group • watermelon • waxgourd, chinese

-- fruit, stone, group 12 at 1.0 ppm

This group includes 14 commodities.
apricot • cherry, sweet • cherry, tart • fruit, stone • fruit, stone, except plum, prune, dried • nectarine • peach • plum • plum, chickasaw • plum, damson • plum, japanese • plum, prune • plum, prune, dried • plum, prune, fresh

-- cranberry at 1.0 ppm.

Pesticide Emergency Exemptions:

• Massachusetts. EPA authorized the use of indoxacarb on cranberry to control cranberry weevil; May 12, 2005 to June 30, 2005. Contact: (Stacey Groce)

IR-4 & DuPont. Pesticide Petition for Indoxacarb and its R-enantiomer; in or on the following raw agricultural commodities:

Residue Chemistry. The active ingredient in the end-use formulation, DuPont\TM\ Avaunt[reg] insecticide, is a 75:25 mixture of two isomers, indoxacarb (DPX-KN128) and IN-KN127. Only one of the isomers, indoxacarb (DPX-KN128), has insecticidal activity. Since the insecticidal efficacy is based on the concentration of indoxacarb (DPX-KN128), the application rates have been normalized on an indoxacarb (DPX-KN128) basis. The
proposed tolerance expression includes both indoxacarb (DPX-KN128) and IN-KN127, and the residue method does not distinguish between the enantiomers. Therefore, residues are reported as the sum of indoxacarb
(DPX-KN128) combined with IN-KN127. Residues of indoxacarb (DPX-KN128) combined with IN-KN127 will be referred to as KN128/KN127.

Acute neurotoxicity study.
• In an acute neurotoxicity study, indoxacarb exhibited decreased forelimb grip strength, decreased foot splay, and some evidence of slightly reduced motor activity, but only at the highest doses tested. The no observed adverse effect level (NOAEL) was 100 milligrams/kilogram (mg/kg) for males, and 12.5 mg/kg for females, based on body weight effects in females 50 mg/kg.

Reproductive and developmental toxicity.
• In a 2-generation rat reproduction study, the parental NOAEL was 1.5 mg/kg/day. The parental NOAEL was based on observations of reduced weight gain and food consumption for the higher concentration groups of the F 0 generation and potential treatment-related changes in spleen weights for the higher groups of the F 1 generation.
• The NOAEL for fertility and reproduction was 6.4 mg/kg/day. The offspring NOAEL was 1.5 mg/kg/day, and was based on the reduced mean pup weights noted for the F 1 litters of the higher concentration groups.
• Developmental studies conducted in rats and rabbits demonstrated that the rat was more susceptible than the rabbit to the maternal and fetal effects of DPX- MP062.
• The NOAEL for maternal and fetal effects in rats was 2 mg/kg/day based on body weight effects and decreased food consumption at 4 mg/kg/day.
• The NOAEL for developmental effects in fetuses was >4 mg/kg/day. In rabbits, the maternal and fetal NOAELS were 500 mg/kg/day based on body weight effects, decreased food consumption in dams and decreased weight and delayed ossification in fetuses at 1,000 mg/kg/day.

Chronic toxicity.
• The chronic NOAEL in male rats was 5 mg/kg/day based on body weight and nutritional effects. In females, the NOAEL of 2.1 mg/kg/day was based on body weight and nutritional changes, as well as biologically significant hematologic changes at 3.6 mg/kg/day and above. Hemolytic effects were present only through the 6-month evaluation and only in females.
• In mice, the chronic NOAEL of 2.6 mg/kg/day for males was based on deceased body weight and weight gain effects and food efficiency at 13.8 mg/kg/day and above. The NOAEL for females was 4.0 mg/kg/day based on body weight nutritional effects, neurotoxicity, and clinical signs at 20 mg/kg/day. In dogs, the chronic NOAEL was about 2.3 and 2.4 mg/kg/day in males and females, respectively based on hemolytic effects similar to those seen in the subchronic dog study.

Subchronic toxicity.
• Mice were less sensitive to indoxacarb than the rats or dogs. NOAELs (23 mg/kg/day, males, 16 mg/kg/day, females) were based on mortality (males only); increased reticulocytes and Heinz bodies and decreased body weight, weight gain, food consumption, food efficiency; and increased clinical signs (leaning to one side and/or with abnormal gait or mobility) (females only). In a 28-day repeated dose dermal study, the NOAEL was 50 mg/kg/day based on decreased body weights, body weight
gains, food consumption, and food efficiency in females, and changes in hematology parameters, the spleen and clinical signs of toxicity in both sexes in rats.