Fipronil
CAS No. 120068-37-3
US Federal Register
 
 

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ACTIVITY: Acaracide, Insecticide (pyrazole), Wood Preservative (to control termites)

CAS NAME: 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile

Structure:

US Federal Register

Date Published Docket Identification Number Details
August 25, 2006 EPA-HQ-OPP-2006-0659 Pesticide Emergency Exemptions; Agency Decisions and State and Federal Agency Crisis Declarations
• Oregon: On May 10, 2006, for the use of fipronil on rutabaga and turnip to control cabbage maggots. This program is expected to end on September 30, 2006.
August 24, 2005 OPP-2005-0206

BASF & IR-4: Pesticide tolerance petitions.

Pesticide petition 5F6948 from BASF for residues of mixture comprising fipronil, and its metabolites
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl) sulfonyl]-1H-pyrazole-3-carbonitrile
and
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)thio]-1H-pyrazole-3-carbonitrile
and its photodegradate 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(1R,S)-(trifluoromethyl)]-1H-pyrazole-3-carbonitrile

in or on the raw agricultural commodities
corm vegetables (crop group 1-C) 0.04 ppm
and indirect and inadvertent residues on
wheat, grain 0.005 ppm
wheat, forage 0.02 ppm
wheat, hay and straw 0.03 ppm

Pesticide petition 2E6490 from the Interregional Research Project No. 4 (IR-4), for residues of
mixture comprising fipronil, and its metabolites

5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl) sulfonyl]-1H-pyrazole-3-
carbonitrile
and
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)thio]-H-pyrazole-3-carbonitrile
and its photodegradate

5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(1R,S)-(trifluoromethyl)]-1H-pyrazole-3-carbonitrile
in or on the raw agricultural commodities:
onion (dry bulb) 0.02 ppm
garlic 0.02 ppm
shallot (dry bulb) 0.02 ppm

Fipronil and its sulfone and amide constitute greater than 75% of the identified residues in all studies.
Reproductive and developmental toxicity. The developmental toxicity NOELs in the rat and rabbit were 20 mg/kg/day (HDT) and 1 mg/kg/day (HDT), respectively. Maternal toxicity was observed in the rat at the HDT as evidenced by decreased body weight gain and food efficiency. In the rabbit, the maternal toxicity NOAEL was less than 0.1 mg/kg/day, based on reduced body weight gain and food efficiency at all dose levels tested. In a two-generation rat study, the NOEL for parental (systemic) toxicity was 3 ppm (0.26 mg/kg/day for both sexes combined), based on increased weight of the thyroid glands and liver in males and females, decreased weight of the pituitary gland in females, and an increased incidence of follicular epithelial hypertrophy in females at 30 ppm. The NOEL for reproductive toxicity was 30 ppm (2.64
mg/kg/day for both sexes combined), based on clinical signs of toxicity in pups, decreased litter size, decreased pup body weights, decreased mating, decreased fertility index, reduced pre- and postnatal survival, and delays in physical development at 300 ppm (26.03 and 28.40 mg/kg/day for males and females, respectively).
In a developmental neurotoxicity study in the rat, the NOAEL for maternal toxicity was 10 ppm (0.91 mg/kg/day), based on decreased body weights and body weight gain at 200 ppm (HDT; 15 mg/kg/day). Considerable maternal toxicity at the HDT prevented adequate neurotoxicity evaluation of pups at this dose level. There was no evidence of neurotoxicity at 10 ppm (0.91 mg/kg/day), which was the NOAEL for developmental neurotoxicity. The NOAEL for general developmental toxicity was 0.5 ppm (0.05 mg/kg/day), based on systemic effects consisting of decreases in pup weights during lactation and increases in time of preputial separation in males at 10 ppm.
Subchronic toxicity. The NOAEL for systemic toxicity in rat was 5 ppm (0.35 mg/kg/day for both sexes combined), based on alterations in serum protein values and increased weight of the liver and thyroid at 30 ppm (1.93 and 2.28 mg/kg/day for males and females, respectively). The NOAELs in the dog were 2 and 0.5 mg/kg/day for male and female, respectively, based on clinical signs of toxicity in males at 10 mg/kg/day and clinical signs of toxicity and decreased body weight gain in females at 2 mg/kg/day. The NOAEL for mice was 10 ppm (1.27 and 1.72 mg/kg/day for males and females, respectively), based on a possible decreased body weight gain at 25 ppm (3.2 and 4.53 mg/kg/day for males and females, respectively). A repeated dose dermal study in the rabbit had a systemic NOAEL of 5 mg/kg/day, based on decreased body weight gain and food consumption at 10 mg/kg/day, and a dermal irritation NOEL of 10.0 mg/kg/day (HDT).
Subchronic neurotoxicity study in rats, the NOEL was 5 ppm (0.301 and 0.351 mg/kg/day for males and females, respectively), based on results of the functional observational battery (FOB) at 150 ppm (8.89 and 10.8 mg/kg/day for males and females, respectively).
Chronic toxicity. The NOAEL for systemic toxicity in a 1-year feeding study in the dog was 0.3 mg/kg/day in females and 1 mg/kg/day in males, based on clinical signs of neurotoxicity at 1 and 2 mg/kg/day in females and males, respectively. The NOAEL for systemic toxicity in mice was 0.5 ppm (0.06 mg/kg/day) based on decreased body weight gain, decreased food conversion efficiency in males, increased liver weights, and liver histopathology at 10 ppm (1.3 mg/kg/day). Fipronil was not
carcinogenic when administrated to mice at dose levels up to 60 ppm. The NOAEL in a 2-year dietary study in the
rat was 0.5 ppm (0.019 and 0.025 mg/kg/day for males and females, respectively) based on clinical signs of toxicity and alterations in clinical chemistry and thyroid parameters at 1.5 ppm (0.059 and 0.078 mg/kg/day for males and females, respectively).
• Cancer. The EPA's Health Effects Division Carcinogenicity Peer Review Committee classified fipronil in Group C - Possible Human Carcinogen, based on thyroid tumors observed in rats at 300 ppm (HDT). Mechanistic data indicate that these tumors are related to a disruption in the thyroid-pituitary status and are specific to the rat. In addition, there was no apparent concern for mutagenic activity. Thus, it was recommended that RfD methodology, i.e. non-linear or threshold, be used for the estimation of human risk.
Acute neurotoxicity.
The NOEL was 2 mg/kg, based on decreases in body weight gain and food consumption in males and females during the week following treatment, decreases in locomotor activity, hind-limb splay and rectal temperature 6-hour post dosing in males and females, and decreases in the proportion of males with an immediate righting reflex on days 7 and 14, at 12 mg/kg/day. In a rat developmental toxicity study, the NOEL was 1 mg/kg/day, based on the slight increase in fetal and litter incidence of reduced ossification of several bones at 2.5 mg/kg/day.
• Subchronic toxicity. The NOAEL in the rat was 3 ppm (0.18 and 0.21 mg/kg/day in males and females, respectively), based on clinical signs of toxicity in both sexes and decreased body weight and body weight gain in males at 10 ppm. The NOEL for the mouse was 0.5 ppm (0.08 mg/kg/day), based on the aggressive and irritable behavior with increased motor activity in males at 2 ppm. The NOEL for the dog was 9.5 ppm (0.29 mg/kg/day), based on behavioral changes in females at 35 ppm (1.05 mg/kg/day).
The rat chronic/carcinogenicity study was negative for carcinogenicity. The LOAEL for females was 0.5 ppm (0.032 mg/kg/day), based on clinical signs of toxicity. There was no NOEL established. For males, the NOAEL was 2 ppm (0.098 mg/kg/day), based on clinical signs of toxicity, and stomach and lung histopathology at 10 ppm (0.497 mg/kg/day).
Endocrine disruption. Data from the reproduction/ developmental toxicity and short- and long-term repeated dose toxicity studies with fipronil in the rat, rabbit, mouse, or dog, do not suggest any endocrine disruption activity. This information is based on the absence of any treatment-related effects from the histopathological examination of reproductive organs as well as the absence of possible effects on fertility, reproductive performance, or any other aspect of reproductive function, or on growth and development of the offspring. Evidence of offspring toxicity was observed only in the presence of significant parental toxicity. Fipronil disrupts the thyroid-pituitary axis. However, mechanistic studies have demonstrated that fipronil decreases thyroid hormone levels in long-term studies via increased clearance, rather than a direct effect on the thyroid. Concerns related
to long-term exposure of fipronil are addressed in human risk estimates, as the chronic RfD (0.0002 mg/kg/day) is based on endpoints that include thyroid hormone related effects in rats.
• Drinking Water.
A drinking water monitoring study for fipronil and relevant metabolites in surface water from the corn growing regions has been conducted (MRID 45526101). The ground water values model by the EPA when the cotton use was examined will also be used for comparison. The samples were collected on regular intervals between April and August. The water samples wereanalyzed for firponil and metabolites: MB45950, MB46136, and MB46513.
Post-application exposure of children can occur from three scenarios:
(1) Incidental ingestion of fipronil pellets or granules;
(2) incidental ingestion of soil (hand to mouth) from fipronil treated residential areas; and
(3) incidental ingestion (hand to mouth) of fipronil from treated pets.

August 17, 2005 OPP-2005-0222

Requests to Voluntarily Cancel Certain Pesticide Registrations.

Registration no. Product Name Chemical Name Registrants Requesting Voluntary Cancellation
000432 AZ-04-0004 Topchoice Fipronil Bayer Environmental Science, A
Business Group of Bayer
Cropscience LP, 2 T. W.
Alexander Drive, Research
Triangle Pa, NC 27709.
August 3, 2005 OPP-2005-0201

Cancellation of Pesticides for Non-payment of Year 2005 Registration Maintenance Fees.

Section 3 registrations canceled for non-payment of the 2005
maintenance fee are shown in the following table 2:

Table 2.--Section 3 Registrations Canceled for Non-Payment of
Maintenance Fee

Registration no. Product Name
000264-00576 Icon 80 WG Insecticide
000264-00577 Icon 6.2 FS
000264-00580 Icon 6.2SC Insecticide
March 10, 2005 OPP-2005-0057 Bayer CropScience.Requests to Voluntarily Cancel Certain Pesticide Registrations.
Registration No. Product Name Company Name and Address
000264-00576 Icon 80 WG
Insecticide.

Bayer Cropscience LP, 2 T.W.
Alexander Drive, Research
Triangle Pa, NC 27709

EPA Company No. 000264

000264-00577 Icon 6.2 FS
000264-00580 Icon 6.2SC
Insecticide
Nov 10, 2004 OPP-2004-0232

EPA denied three requests for Pesticide Emergency Exemptions.

Delaware - Department of Agriculture
Denial: On April 28, 2004, EPA denied the use of fipronil on potatoes
to control wireworms. This request was denied based on the
determination that the situation as described in the application does
not meet the criteria for an emergency since growers are not likely to
experience significant economic losses from wireworm infestations.
Further, the Agency also believes that the use of fipronil will not
improve the economic conditions facing potato growers because
fipronil's performance against wireworms is just as erratic as the
registered alternatives and its use will not result in any improvement
in yield or quality. Contact: (Barbara Madden).

New Jersey - Department of Environmental Protection
Denial: On April 28, 2004, EPA denied the use of fipronil on potatoes
to control wireworms. The same rationale for denial to Delaware was given.

Virginia - Department of Agriculture and Consumer Services
Denial: On April 28, 2004, EPA denied the use of fipronil on potatoes
to control wireworms.
The same rationale for denial to Delaware was given.

Oct 27, 2004 OPP-2004-0338 Cancellation of Pesticides for Non-payment of Year 2004 Registration Maintenance Fees.
Table 1.--Section 24(c) Registrations Canceled for Non-Payment of
Maintenance Fee
Name of Pesticide Product Name Registrant SLN No.
Fipronil Maxforce TMS Bayer Environmental Science 000432 CT-03-0001
Fipronil Termidor(r) SC Insecticide BASF Corporation 000432 LA-99-0014
July 1, 2004 OPP-2004-0208

Bayer CropScience. Cancellation Order for Certain Product Registrations.

Approved Registration Cancellations
Registration No. Product name Chemical name
264-576 Icon 80WG fipronil
264-577 Icon 6.2FS fipronil
264-580 Icon 6.2SC fipronil
EPA Company No. Company name and address
264 Bayer CropScience,
2 T.W. Alexander Drive,
Research Triangle Park, NC 27709
June 9, 2004 OPP-2004-0131 Extension of public comment period on voluntary cancellation of certain products (see May 7, 2004, below). On May 20, 2004, EPA received a request from the USA Rice Federation for an extension of the time period to July 1, 2004, so that the USA Rice Federation may negotiate with the registrant, Bayer Crop Science, to withdraw its voluntary cancellation request. In light of the fact that the registrations will expire on July 1, 2004, the Agency will extend the comment period to June 21, 2004, not July 1, 2004.
May 7, 2004 OPP-2004-0131

Bayer CropScience. Notice of Request to Voluntarily Cancel Certain Pesticide Registrations. Unless a request is withdrawn by the registrant within 30 days of publication of this notice, orders will be issued canceling all of these registrations.

Approved Registration Cancellations
Registration No. Product name Chemical name
264-576 Icon 80WG fipronil
264-577 Icon 6.2FS fipronil
264-580 Icon 6.2SC fipronil
EPA Company No. Company name and address
264 Bayer CropScience,
2 T.W. Alexander Drive,
Research Triangle Park, NC 27709
March 4, 2004 ORD-2003-
0011

Announcement: Longitudinal Study of Young Children's Exposures in their Homes to Selected Pesticides, Phthalates, Brominated Flame Retardants, and Perfluorinated Chemicals (A Children's Environmental Exposure Research Study--CHEERS).

Abstract: The U.S. EPA's Office of Research and Development's National Exposure Research Laboratory proposes to conduct a two-year longitudinal field measurement study of young children's (aged 0 to 3 years) potential exposures to current-use pesticides and selected phthalates, polybrominated diphenyl ethers, and perfluorinated compounds that may be found in residential environments. The study will be conducted in Duval County, Jacksonville, Florida over a two-year period from 2004 to 2006. Sixty young children will be recruited into this study in two cohorts: (1) infants recruited into the study soon after birth, and, (2) children recruited into the study at approximately 12 months of age.

Part A: Supporting Statement - EPA ICR Number: 2126.01 - 61 pages
From Table 2:
• Of 16 pesticides included in this study, 4 are fluorinated:
Bifenthrin, Fipronil, lamda-Cyhalothrin, and Cyfluthrin I, II, III, IV, total
• Perfluorinated chemicals:
Perfluorooctanoic acid (PFOA) and Perfluorooctane sulfonate (PFOS)

From Table 3: List of chemicals to be analyzed in biological media:
• one is fluorinated: 4-fluoro-3-phenoxybenzoic acid
• Perfluorooctanoic acid/Perfluorooctane sulfonate

Nov 26, 2003 OPP-2003-0358 2 Pesticide Emergency Exemptions. ``Quarantine'' and ``public health'' exemptions are a particular form of specific exemption issued for quarantine or public health purposes. These are rarely requested.
-- New Jersey Department of Environmental Protection. Public Health. EPA authorized the use of fipronil in a rodent bait box system to control immature blacklegged ticks which are vectors for lyme disease; May 24, 2003 to December 31, 2003. Lyme disease is caused by the bacterium, borrelia burgdorferi. These bacteria are transmitted to humans by the bite of infected deer ticks.
-- New York Department of Environmental Conservation. Public Health. EPA authorized the use of fipronil in a rodent bait box system to control immature blacklegged ticks which are vectors for lyme disease; May 9, 2003 to December 31, 2003. Lyme disease is caused by the bacterium, borrelia burgdorferi. These bacteria are transmitted to humans by the bite of infected deer ticks. Contact: (Barbara Madden).
Aug 7, 2002 OPP-2002-0164

Emergency Exemptions for pesticide use. Connecticut Department of Environmental Protection Public Health; New Jersey Department of Environmental Protection Public Health; and New York Department of Environmental Conservation Public Health. EPA authorized the use of fipronil in a rodent bait box system to control immature blacklegged ticks which are vectors for Lyme disease. Lyme disease is a serious public health concern. Lyme disease is caused by the bacterium, Borrelia burgdorferi. These bacteria are transmitted to humans by the bite of infected deer ticks and cause more than 16,000 infections in the United States each year. Lyme disease is spread by the bite of ticks of the genus Ixodes that are infected with Borrelia burgdorferi.; April 26, 2002 to December 31, 2002.

Nov 14, 2001 OPP-181082 Pesticide Emergency Exemptions. Louisiana: On May 19, 2001, EPA authorized use on wood structures to control Formosan termites. This program ended on May 19, 2001.
March 3, 1999 NA

RHONE POULENC - Extension of Experimental Use Permit: 264-EUP-117. This EUP allows the use of 75 pounds of the insecticide Regent 2.5 EC Insecticide on 250 acres of cotton on a crop destruct basis to evaluate the control of key pests of cotton. The program is authorized only in the States of AL, AZ, AR, CA, LA, MSi, TN, and TX. The EUP was previously effective from April 24, 1998 to April 24, 1999; the experimental use permit is now effective from April 24, 1999 to April 24, 2000. This permit is issued with the limitation that all treated crops will be destroyed or used for research purposes only.

Jan 29, 1999 NA

RHONE POULENC - Issuance of Experimental Use Permit: 264-EUP-119. This EUP allows the use of 0.0012 pounds of the insecticide fipronil on 60 acres of turfgrass that is not used for grazing or recreation to evaluate the control of imported fire ants. The program is authorized only in the States of Florida, Georgia, Louisiana, Mississippi, North Carolina, South Carolina, and Texas. The experimental use permit is effective from December 21, 1998 to December 21, 1999.

July 17, 1998 OPP-300612

RHONE POULENC - Petition. Pesticide Tolerances for rice: grain at 0.04 ppm, and straw at 0.10 ppm. - FINAL RULE.

Nov 26, 1997 OPP-300587

RHONE POULENC - Pesticide Tolerances for residues and metabolites in or on field corn grain, stover, and forage; milk fat, eggs; poultry fat, meat, and meat byproducts; hog fat, meat, meat byproducts, and liver; and liver, fat, meat, and meat byproducts of cattle, goat, horse, and sheep.- FINAL RULE.

July 7, 1997 NA
  • RHONE POULENC - Issuance of 2 Experimental Use Permits:
  • 264-EUP-107; allows the use of 69 pounds of the insecticide 5-amino-1- (2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((1,R,S)- (trifluoromethyl)sulfinyl)-1-H-pyrazole-carbonitrile on 230 acres of cotton to evaluate the control of the boll weevil, fleahoppers, plant bugs, and thrips. The program is authorized only in the States of Arizona, Louisiana, Mississippi, and Texas. The experimental use permit is effective from June 13, 1997 to June 13, 1998. This permit is issued with the limitation that all treated crops are destroyed or used for research purposes only.
  • 264-EUP-111; allows the use of 4.7 pounds of the insecticide 5-amino-1- (2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((1,R,S)- (trifluoromethyl)sulfinyl)-1-H-pyrazole-carbonitrile on 1,332 acres of rangeland to evaluate the control of grasshoppers. The program is authorized only in the State of Wyoming. The experimental use permit is effective from June 4, 1997 to June 4, 1998. This permit is issued with the limitation that all treated acreage will be fenced so that no livestock will be grazed on the treated acreage, and no grass, hay, or other vegetation from the treated acreage will be cut to be fed to livestock.
June 20, 1997 PF-743
  • RHONE POULENC - Two Pesticide Tolerance Petitions.
  • PP-7F4832; for the combined residues of the insecticide fipronil and its metabolites 5-amino-1-[2,6-dichloro-4- (trifluoromethyl)phenyl]-4-[(trifluoromethyl) sulfonyl]-1H-pyrazole-3- carbonitrile; and 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4- [(trifluoromethyl)thio]-1H-pyrazole-3-carbonitrile; and 5-amino-1-[2,6- dichloro-4-(trifluoromethyl)phenyl]-4-[(1RS)-(trifluoromethyl)]-1H- pyrazole-3-carbonitrile on or in the following raw agricultural commodities: potatoes at 0.02 ppm, sweet potatoes at 0.02 ppm, rice grain at 0.02 ppm, rice straw at 0.10 ppm, cottonseed at 0.05 ppm, and cotton gin trash at 3.0 ppm.
  • PP-5F4426; for the combined residues of the insecticide fipronil and its metabolites on or in the following raw agricultural commodities: corn grain at 0.02 ppm, corn forage at 0.15 ppm and corn stover at 0.15 ppm; in the animal product commodities of cattle, goats, horses and sheep: fat at 0.40 ppm, liver at 0.10 ppm, meat at 0.04 ppm, meat by-products (except liver) at 0.04 ppm, beef kidney at 0.03 ppm, and milk fat at 0.70 ppm; in the animal product commodities of hogs: fat at 0.04 ppm, liver at 0.02 ppm, meat at 0.01 ppm and meat by-products (except liver) at 0.01 ppm; in the animal product commodities of poultry: eggs at 0.03 ppm, fat at 0.05 ppm and meat at 0.02 ppm.
April 11, 1997 NA
  • RHONE POULENC - Issuance of 2 Experimental Use Permits:
  • 264-EUP-104. Extension. Allows the use of 3.0 pounds of the insecticide 5-amino-1- (2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((1,R,S)- (trifluoromethyl)sulfinyl)-1-H-pyrazole-carbonitrile on 60 acres of rice to evaluate the control of the rice water weevil. The program is authorized only in the States of Arkansas, California, Louisiana, Mississippi, and Texas. The experimental use permit is effective from March 7, 1997 to March 7, 1998. This permit is issued with the limitation that all treated crops are destroyed or used for research purposes only.
  • 264-EUP-105. Extension. Allows the use of rice seed treated with 1.95 pounds of the insecticide 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4- ((1,R,S)-(trifluoromethyl)sulfinyl)-1-H-pyrazole-carbonitrile on 50 acres of rice to evaluate the control of the rice water weevil. The program is authorized only in the States of Arkansas, Louisiana, Mississippi, and Texas. The experimental use permit is effective from March 7, 1997 to March 7, 1998. This permit is issued with the limitation that all treated crops are destroyed or used for research purposes only.
June 12, 1996 NA

RHONE POULENC - Petition. Approval of Pesticide Product Registrations: Chipco Choice (formerly Chipco Gauntlet 0.1G) for use on golf and commercial turf to control mole crickets (EPA Reg. No. 264-550); and Fipronil Technical for formulation into insecticide products (EPA Reg. No. 264-554).

May 15, 1996 NA

RHONE POULENC - Experimental Use Permit 264-EUP-101 to allow the use of 31.46 pounds of the insecticide on 242 acres of field corn to evaluate the control of corn rootworms. The program is authorized only in the States of IN, IL, IA, MN, NE, OH, and WI. The permit is effective from April 4, 1996 to March 28, 1997.

May 1, 1996 OPP-30408
April 10, 1996 NA

RHONE POULENC - Extension of Experimental Use Permit 264-EUP-95 for 31.46 pounds of the insecticide on 242 acres of field corn. The program is authorized only in the States of IL, IN, IA, MN, NE, OH, and WI [Note: SD is not included]. .

Feb 28, 1996 NA

RHONE POULENC - Renewal of Temporary Tolerance of the insecticide or its metabolites in or on the raw agricultural commodity field corn grain at 0.02 ppm. This temporary tolerance expires March 28, 1997.

Sept 27, 1995 NA
  • RHONE POULENC - Issuance of Two Experimental Use Permits
  • 264-EUP-95; allow the use of 31.46 pounds of the insecticide on 242 acres of field corn to evaluate the control of northern and western corn rootworm larvae and wireworms. The program is authorized only in the States of Illinois, Indiana, Iowa, Minnesota, Nebraska, Ohio, South Dakota, and Wisconsin. The experimental use permit is effective from March 28, 1995 to March 28, 1996.
  • 264-EUP-100; allow the use of 10.1 pounds of the insecticide on 264 acres of turf grass on golf courses to evaluate the control of mole crickets. The program is authorized only in the States of Alabama, Georgia, Florida, Mississippi, North Carolina, and South Carolina. The experimental use permit is effective from July 17, 1995 to December 31, 1996.
June 28, 1995 OPP-30389

RHONE MERIEUX - Application to Register the insecticide "Frontline Spray Treatment." Proposed classification/Use: General. For the control of ticks and fleas on dogs, puppies, cats, and kittens.

June 15, 1995 PF-626;
FRL 4955-4

RHONE POULENC - Petition; to amend tolerances in or on corn, grain at 0.02 ppm, corn, fodder at 0.15 ppm, and corn, forage at 0.15 ppm; poultry eggs, liver, and muscle at 0.02 ppm and skin/fat at 0.03 ppm; dairy cow milk, liver, kidney, and muscle at 0.02 ppm, and fat at 0.08 ppm.

May 31, 1995 OPP-30387

RHONE POULENC - Application to Register the products: Fipronil Technical, for formulation into an insecticide; Regent 1.5G Insecticide, for use on corn to control northern and western corn, rootworm larvae, and wireworms; and Chipco Gauntlet 0.1G, for use on golf and commercial turfgrass and to control mole crickets in turfgrass.

May 17, 1995 NA

RHONE POULENC - Establishment of a Temporary Tolerance for the combined residues of the insecticide and its metabolites in or on the raw agricultural commodity field corn grain at 0.02 ppm; the temporary tolerance expires March 28, 1996.

 
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