Flumioxazin
CAS No. 103361-09-7
 
 

Return to
Adverse Effects
Abstracts

ACTIVITY: Herbicide (n-phenylphthalimide or dicarboximide)

CAS Name: 2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione

Structure:

Adverse Effects:

Anemia
Blood
Body Weight Decrease
Bone
Brain
Cholesterol
Cytotoxic (results equivocal)
Endocrine: Adrenal
Endocrine: Testicular
Endocrine: Thymus
Endocrine: Thyroid
Heart
Kidney
Liver
Lymph Node
Teratogen

Environmental Effects:

Phototoxic Pesticide

Toxic to aquatic invertebrates.

Highly toxic to terrestrial plants

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 129034 
California Chemical Code 5802  
US Tolerances: CFR 180.568 
Registered use in
(includes only a limited list of countries)

Argentina, China, Brazil, France, Hungary, Israel, Japan, Paraguay, South Africa, USA, Zimbabwe.

Argentina, soybean at 0.015 ppm; sunflower at 0.02 ppm.

Brazil, soybean at 0.05 ppm.

France, grape at 0.05 ppm.

Paraguay, soybean at 0.015 ppm.

South Africa, soybean at 0.02 ppm; groundnut at 0.02 ppm.

Spain, soybean at 0.05 ppm; peanut at 0.05 ppm.

Ref: March 17, 2004, Federal Register.

Japan & US - (see below)

Japan Maximum Residue Levels (MRLs) Apple • Grape • Grapefruit • Japanese pear • Lemon • Lime • NATSUDAIDAI (whole) • Orange (including Navel) • Other Citrus fruits • Peanuts (dry) • Pear • Soybeans (dry) • UNSHU orange
US Maximum Residue Levels permitted in food commodities
Permitted in or on 38 food commodities
Almond (hulls & nutmeat) • Cotton (gin byproducts & undelinted seed) • Arracacha • Arrowroot • Artichoke, (chinese & jerusalem) • Canna, edible • Cassava • Chayote root • Chufa • Dasheen •
Garlic (bulb) • Ginger • GrapeOnion (dry bulb) • Leren • Peanuts • Peppermint (tops) • Pistachio • Potato • Potato culls • Potato granules flakes • Potato peel, wet • Potato processed potato waste • Potato, specialty • Shallot (bulb) • Soybean seed  • Spearmint (tops) • Sugarcane (cane) • Sweet potato • Sweet Potato, Roots • Tanier • Turmeric • Yam (bean & true) 
Other Information
Molecular Formula: C19H15 F N2O4 
Entry Year: 1989 
Inventing Company: Sumitomo 
Manufacturers: Sumitomo, Valent 
Other Names:

BroadStar
Flumioxazine

Sumisoya
SureGuard
Valor 50 WD
S-53482
V-53482
59639-EUP-118
 

Manufacture site: JAPAN:
SUMITOMO CHEMICAL COMPANY LTD, OITA WORKS, 2200 TSURUSAKI, OITA-CITY OITA 870-01
 
Of special interest:
PAN Data
Material Safety Data Sheets & Labels
April 8, 2005 - Two new Valent herbicides received okay from New York state: BroadStar and SureGuard.
December 2003 - Evaluation of the new active Flumioxazin in the product Pledge 500 WG Herbicide. Australian Pesticides and Veterinary Medicines Authority. ISSN1443-1335.
The applicant, Sumitomo Chemical Australia, is seeking registration of the product for the knockdown and control of various grass and broadleaved weeds when mixed with glyphosate or paraquat/diquat herbicides prior to sowing wheat, barley, lupins, canola, cotton, oats, faba beans, field peas, chick peas and lentils.
January 2003 (revised) - Summary of Toxicological Data. California EPA, Department of Pesticides Regulation, Medical Toxicology Branch.
June 27, 2002. Review report for the active substance flumioxazine. 7471/VI/98-Final. European Commission. Directorate-General Health & Consumer Protection.
April 12, 2001 - US EPA Pesticide Fact Sheet
Profile from Hazardous Substances Data Bank 
February 18, 2002 - European Commission decision to extend provisional authorisation granted for new active substances including flumioxazine
March 7, 2001 - Phototoxic Pesticides: US EPA Memo Requesting Phototoxicity Study Protocol for Light-Dependent Peroxidizing Herbicides
Abstracts 
April 13, 2001 - Two U.S. congressmen successfully campaign for flumioxazin use in 2001 growing season. - Press Release from Saxby Chambliss, Georgia's 8th Congressional District.
April 17, 2001 - Georgia Peanut Commission applauds EPA's approval. - Press Release, Georgia Peanut Commission. 
August 2001 - IR-4: New Products/Transitional Solution List - This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes: Flumioxazin  
October 2001 - Glossary of Pesticide Chemicals - A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.


US Federal Register

•• Note: Due to length, the following is a partial list. Click here to see full list of FR entries.

Published Date Docket Identification Number Details
September 28, 2007 EPA-HQ-OPP-2007-0871

Valent U.S.A. Corporation. Proposed pesticide tolerance. Pesticide Petition (PP 7F7243) to establish a tolerance for residues of the herbicide flumioxazin in or on the food commodities

-- corn, field grain at 0.02 ppm;
-- corn, field forage at 0.02 ppm
-- corn, field stover at 0.02 ppm.

Practical analytical methods for detecting and measuring levels of flumioxazin have been developed and validated in or on all appropriate agricultural commodities and respective processing fractions. The level of quantitation (LOQ) of flumioxazin in the methods is 0.02 ppm which will allow monitoring of food with residues at the levels proposed for the tolerances.

September 28, 2007 EPA-HQ-OPP-2006-0781

Valent U.S.A. Corporation. Proposed pesticide tolerance. Pesticide Petition (6F7092) proposes to establish a tolerance for residues of the herbicide in or on the food commodities

-- alfalfa, forage at 1.0 ppm and
-- alfalfa, hay at 2.0 ppm.

June 27, 2007 EPA-HQ-OPP-2007-0308

IR-4. Pesticide Petition. PP 6E7151. Proposal to establish a tolerance for residues of the herbicide flumioxazin in or on food commodities:

asparagus 0.02 ppm
aronia berry 0.02 ppm
dry beans 0.10 ppm
buffalo currant 0.02 ppm

Bushberry, subgroup 13B

This subgroup includes 5 commodities.
blueberry • currant • elderberry • gooseberry • huckleberry

0.02 ppm
Chilean guava 0.02 ppm
European barberry 0.02 ppm
highbush cranberry 0.02 ppm
honeysuckle 0.02 ppm
jostaberry 0.02 ppm
Juneberry 0.02 ppm
lingonberry 0.02 ppm

melon, subgroup 9A

This subgroup includes 6 commodities.
cantaloupe • citron melon • melon • melon, citron • muskmelon • watermelon

0.02 ppm
Native currant 0.02 ppm

nut, tree, crop group 14

This group includes 16 commodities.
almond • almond, hulls • beechnut • butternut • cashew • chestnut • chinquapin • filbert • nut, brazil • nut, hickory • nut, macadamia • nutmeat, processed, except peanut • nuts • pecan • pistachio • walnut

0.02 ppm
okra 0.02 ppm
salal 0.02 ppm
sea buckthorn 0.02 ppm

vegetable, fruiting, crop group 8

This group includes 17 commodities.
chili, postharvest • eggplant • groundcherry • pepino • pepper • pepper, bell • pepper, nonbell • pepper, nonbell, sweet • tomatillo • tomato • tomato, concentrated products • tomato, dried pomace • tomato, paste • tomato, puree • tomato, wet pomace • vegetable, fruiting • vegetable, fruiting, group

0.02 ppm

Practical analytical methods for detecting and measuring levels of flumioxazin have been developed and validated in/on all appropriate agricultural commodities and respective processing fractions. The LOQ of flumioxazin in the methods is 0.02 ppm which will allow monitoring of food with residues at the levels proposed for the tolerances.

June 27, 2007 EPA-HQ-OPP-2007-0308 IR-4. Pesticide Petition. PP 6E7151. Porposal to amend the tolerances in 40 CFR 180.568 for residues of the herbicide flumioxazin in or on the food commodity almond, nutmeats be deleted upon establishment of the crop group tolerance for nut, tree, Crop Group 14.
May 3, 2006 EPA-HQ-OPP-2004-0398 Valent U.S.A. Pesticide tolerance. FINAL RULE.

-- Strawberry at 0.07 ppm

-- Fruit, pome, group 11 at 0.02 ppm

This group includes 10 commodities.
apple • apple, dried pomace • apple, juice • apple, wet pomace • crabapple • fruit, pome • loquat • mayhaw • pear • pear, oriental • quince

-- Fruit, stone, group 12 at 0.02 ppm

This group includes 14 commodities.
apricot • cherry, sweet • cherry, tart • fruit, stone • fruit, stone, except plum, prune, dried • nectarine • peach • plum • plum, chickasaw • plum, damson • plum, japanese • plum, prune • plum, prune, dried • plum, prune, fresh

August 17, 2005 OPP-2005-0222

Requests to Voluntarily Cancel Certain Pesticide Registrations.

Registration no. Product Name Chemical Name Registrants Requesting Voluntary Cancellation
059639 SD-02-0001 Valor WDG Herbicide Flumioxazin Valent U.S.A. Corp., PO Box
8025, Walnut Cre, CA 94596.
059639 SD-03-0003 Gangster V Herbicide Flumioxazin Valent U.S.A. Corp., PO Box
8025, Walnut Cre, CA 94596.
April 8, 2005 OPP-2005-0089

IR-4. Notice of Filing a Pesticide Petition to Establish a Tolerance in or on STRAWBERRY at 0.10 ppm. PP (Pesticide Petition) 4E6845.

The toxicological profile for flumioxazin which supports this petition for tolerances was published in the Federal Register on March 31, 2004.

Nov 10, 2004 OPP-2004-0232

Three Pesticide Emergency Exemptions.
Louisiana
--- Crisis: On May 7, 2004, for the use of flumioxazin on sweet potatoes to control annual broadleaf weeds. This program ended on July 15, 2004. Contact: (Libby Pemberton)
--- Specific: EPA authorized the use of flumioxazin on sweet potatoes to control annual broadleaf weeds; May 13
, 2004 to July 31, 2004. Contact: (Libby Pemberton)
Mississippi - EPA authorized the use of flumioxazin on sweet potatoes to control annual broadleaf weeds; May 13, 2004 to July 31, 2004. Contact: (Libby Pemberton)

•• Note: Due to length, the above is a partial list. Click here to see full list of FR entries.


 
Fluoride Action Network | Pesticide Project | 315-379-9200 | pesticides@fluoridealert.org