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ndex Page
Activity: Herbicide
(Aryloxyphenoxy propionic acid, Glycol
Ether)
Structure:
Adverse
Effects:
Body
Weight Decrease
Bone
Cancer:
Carcinogenic
effects in mice even at very low doses
Embryotoxic
Endocrine:
Vaginal
Teratogenic
Urinary tract
A
1992 Greenpeace
report contains case studies on 5 dangerous pesticides,
including this one, that have never been registered in the
US but are made in the US for export. Greenpeace argues for
an end to the loopholes which allow a double standard between
domestic and export pesticides.
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Body
Weight Decrease (click
on for all fluorinated pesticide)
Abstract: The developmental
toxicity of haloxyfop-ethoxyethyl-ester (87237487) (HEE) was studied
in rats. Pregnant Wistar-rats were gavaged with 5, 10, or 50mg/kg
HEE on days six to 16 of gestation. They were observed for clinical
signs of toxicity and sacrificed on gestational day 21. The uteri
were removed, examined, and the number of implantations, live
and dead fetuses, and resorption sites recorded. The live fetuses
were weighed and examined for malformations. HEE at 10 and 50mg/kg
caused vaginal bleeding in 40 and 50% of the dams, respectively.
The 10 and 50mg/kg doses significantly increased the number of
resorptions per litter and decreased the number of live fetuses
per litter. The 50mg/kg dose caused a significant
decrease in fetal weight. HEE caused a significant
dose related increase in the number of cachectic fetuses.
The proportion of cachectic fetuses
following exposure to 5, 10, and 50mg/kg was 2.0, 6.8, and 20.3%,
respectively. Ureterohydronephrosis was the most frequently observed
soft tissue malformation, the prevalence of this defect following
the 10 and 50mg/kg doses being 42.9 and 54.8%, respectively. The
10
and
50mg/kg doses caused skeletal malformations such as retarded ossification
of the sternum and absence of rib 13. The author concludes that
haloxyfop-ethoxyethyl-ester is embryotoxic and teratogenic. The
no observable effect level is expected to be below 5mg/kg.
Ref: Machera K (1993). Developmental Toxicity
of Haloxyfop Ethoxyethyl Ester in the Rat. Bulletin of Environmental
Contamination and Toxicology, Vol. 51, No. 4, pages 625-632. As
cited at Toxnet.
Definitions:
cachectic - relating
to or having the symptoms of cachexia
cachexia - A profound and marked
state of constitutional disorder, general ill health and malnutrition.
The loss of body weight and muscle mass frequently seen in patients
with advanced diseases. Synonyms: cachexy, wasting
Bone
(click
on for all fluorinated pesticide)
Reproductive Effects:
In rats, oral doses of 10 and 50 mg/kg/day of haloxyfop-ethoxyethyl
from days 6 to 16 of pregnancy reduced the number of live offspring
per litter and caused vaginal
bleeding
in the mother
(5). Teratogenic Effects: Oral doses of 50 mg/kg/day of haloxyfop-ethoxyethyl
in rats between days 6 and 16 of pregnancy caused developmental
abnormalities in the offspring's urogenital system and death to
the fetus (5). Oral doses of 7.5 mg/kg/day of haloxyfop-methyl
given to rats from days 6 to 15 of pregnancy caused delayed
bone formation in the offspring (6).
Ref: EXTOXNET Pesticide Information Profile
http://pmep.cce.cornell.edu/profiles/extoxnet/haloxyfop-methylparathion/haloxyfop-ext.html
Abstract: The developmental
toxicity of haloxyfop-ethoxyethyl-ester (87237487) (HEE) was studied
in rats. Pregnant Wistar-rats were gavaged with 5, 10, or 50mg/kg
HEE on days six to 16 of gestation. They were observed for clinical
signs of toxicity and sacrificed on gestational day 21. The uteri
were removed, examined, and the number of implantations, live
and dead fetuses, and resorption sites recorded. The live fetuses
were weighed and examined for malformations. HEE
at 10 and 50mg/kg caused vaginal bleeding in 40 and 50% of the
dams, respectively. The 10 and 50mg/kg doses significantly increased
the number of resorptions per litter and decreased the number
of live fetuses per litter. The 50mg/kg dose caused a significant
decrease in fetal weight. HEE caused a significant dose related
increase in the number of cachectic fetuses. The proportion of
cachectic fetuses following exposure to 5, 10, and 50mg/kg was
2.0, 6.8, and 20.3%, respectively. Ureterohydronephrosis was the
most frequently observed soft tissue malformation, the prevalence
of this defect following the 10 and 50mg/kg doses being
42.9 and 54.8%, respectively. The 10 and 50mg/kg doses caused
skeletal malformations such as retarded
ossification of the sternum and absence of rib 13. The
author concludes that haloxyfop-ethoxyethyl-ester
is embryotoxic and teratogenic. The no observable effect level
is expected to be below 5mg/kg.
Ref: Machera K (1993). Developmental Toxicity
of Haloxyfop Ethoxyethyl Ester in the Rat. Bulletin of Environmental
Contamination and Toxicology, Vol. 51, No. 4, pages 625-632. As
cited at Toxnet.
Cancer
(click on for all fluorinated
pesticide)
"Haloxyfop-( 2-etoxy-ethyl)
87237-48-7 Banned. Carcinogenic effects
in mice even at very low doses. 1989."
Definition: "Banned. A substance which for health or environmental
reasons by an authority decision is either no longer approved
for any area of application, or for which an approval or registration
has been denied from the first instance."
Ref: Euopean Commission. Appendix 5. Substances
which may not be included as active ingredients in approved pesticide
products, Chapter 15, Section 2, subsection one.
http://www.kemi.se/lagar_eng/pdf/app5_8.pdf
Embryotoxic
(click
on for all fluorinated pesticide)
Abstract: The developmental
toxicity of haloxyfop-ethoxyethyl-ester (87237487) (HEE) was studied
in rats. Pregnant Wistar-rats were gavaged with 5, 10, or 50mg/kg
HEE on days six to 16 of gestation. They were observed for clinical
signs of toxicity and sacrificed on gestational day 21. The uteri
were removed, examined, and the number of implantations, live
and dead fetuses, and resorption sites recorded. The live fetuses
were weighed and examined for malformations.
HEE at 10 and 50mg/kg caused vaginal bleeding in 40 and 50% of
the dams, respectively. The 10 and 50mg/kg doses significantly
increased the number of resorptions per litter and decreased the
number of live fetuses per litter. The 50mg/kg dose caused a significant
decrease in fetal weight. HEE caused
a significant dose related increase in the number of cachectic
fetuses. The proportion of cachectic fetuses
following exposure to 5, 10, and 50mg/kg was 2.0, 6.8, and 20.3%,
respectively. Ureterohydronephrosis was
the most frequently observed soft tissue malformation,
the prevalence of this defect following the 10
and 50mg/kg doses being 42.9 and 54.8%, respectively. The
10 and 50mg/kg doses caused skeletal malformations
such as retarded ossification of the sternum and absence of rib
13. The author concludes that haloxyfop-ethoxyethyl-ester is
embryotoxic and teratogenic.
The no observable effect level is expected to be below
5mg/kg.
Ref: Machera K (1993). Developmental Toxicity
of Haloxyfop Ethoxyethyl Ester in the Rat. Bulletin of Environmental
Contamination and Toxicology, Vol. 51, No. 4, pages 625-632. As
cited at Toxnet.
Definitions:
cachectic - relating
to or having the symptoms of cachexia
cachexia - A profound and marked
state of constitutional disorder, general ill health and malnutrition.
The loss of body weight and muscle mass frequently seen in patients
with advanced diseases. Synonyms: cachexy, wasting
Endocrine:
Vaginal (click
on for all fluorinated pesticide)
Reproductive Effects:
In rats, oral doses of 10 and 50 mg/kg/day of haloxyfop-ethoxyethyl
from days 6 to 16 of pregnancy reduced the number of live offspring
per litter and caused vaginal bleeding
in the mother (5). Teratogenic Effects: Oral doses of 50 mg/kg/day
of haloxyfop-ethoxyethyl in rats between days 6 and 16 of pregnancy
caused developmental abnormalities in the offspring's urogenital
system and death to the fetus (5). Oral doses of 7.5 mg/kg/day
of haloxyfop-methyl given to rats from days 6 to 15 of pregnancy
caused delayed bone formation in the offspring (6).
Ref: EXTOXNET Pesticide Information Profile
http://pmep.cce.cornell.edu/profiles/extoxnet/haloxyfop-methylparathion/haloxyfop-ext.html
Teratogenic
(click on for all fluorinated
pesticide)
Teratogenic
Effects: Oral doses of 50 mg/kg/day of haloxyfop-ethoxyethyl
in rats between days 6 and 16 of pregnancy caused developmental
abnormalities in the offspring's urogenital system and
death to the fetus (5). Oral doses of 7.5 mg/kg/day of haloxyfop-methyl
given to rats from days 6 to 15 of pregnancy caused delayed bone
formation in the offspring (6).
Ref: EXTOXNET Pesticide Information Profile
http://pmep.cce.cornell.edu/profiles/extoxnet/haloxyfop-methylparathion/haloxyfop-ext.html
Abstract:
The developmental toxicity of haloxyfop-ethoxyethyl-ester (87237487)
(HEE) was studied in rats. Pregnant Wistar-rats were gavaged with
5, 10, or 50mg/kg HEE on days six to 16 of gestation. They were
observed for clinical signs of toxicity and sacrificed on gestational
day 21. The uteri were removed, examined, and the number of implantations,
live and dead fetuses, and resorption sites recorded. The live
fetuses were weighed and examined for malformations. HEE at 10
and 50mg/kg caused vaginal bleeding in 40 and 50% of the dams,
respectively. The 10 and 50mg/kg doses significantly increased
the number of resorptions per litter and decreased the number
of live fetuses per litter. The 50mg/kg dose caused a significant
decrease in fetal weight. HEE caused a significant dose related
increase in the number of cachectic fetuses. The proportion of
cachectic fetuses following exposure to 5, 10, and 50mg/kg was
2.0, 6.8, and 20.3%, respectively. Ureterohydronephrosis was the
most frequently observed soft tissue malformation, the prevalence
of this defect following the 10 and 50mg/kg doses being 42.9 and
54.8%, respectively. The 10 and 50mg/kg doses caused skeletal
malformations such as retarded ossification of the sternum and
absence of rib 13. The author concludes that haloxyfop-ethoxyethyl-ester
is embryotoxic and teratogenic.
The no observable effect level is expected to be below 5mg/kg.
Ref: Machera K (1993). Developmental Toxicity
of Haloxyfop Ethoxyethyl Ester in the Rat. Bulletin of Environmental
Contamination and Toxicology, Vol. 51, No. 4, pages 625-632. As
cited at Toxnet.
Urinary
Tract
(click on for all fluorinated
pesticide)
Reproductive Effects:
In rats, oral doses of 10 and 50 mg/kg/day
of haloxyfop-ethoxyethyl from days 6 to 16 of pregnancy reduced
the number of live offspring per litter and caused vaginal bleeding
in the mother (5). Teratogenic Effects: Oral doses of 50 mg/kg/day
of haloxyfop-ethoxyethyl in rats between days 6 and 16
of pregnancy caused developmental abnormalities
in the offspring's urogenital system and death to the fetus
(5). Oral doses of 7.5 mg/kg/day of haloxyfop-methyl given to
rats from days 6 to 15 of pregnancy caused delayed bone formation
in the offspring (6).
Ref: EXTOXNET Pesticide Information Profile
http://pmep.cce.cornell.edu/profiles/extoxnet/haloxyfop-methylparathion/haloxyfop-ext.html
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