Adverse Effects
Haloxyfop-etotyl
CAS No. 87237-48-7

 
 

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Activity: Herbicide (Aryloxyphenoxy propionic acid, Glycol Ether)
Structure:


Adverse Effects:
Body Weight Decrease
Bone
Cancer: Carcinogenic effects in mice even at very low doses
Embryotoxic
Endocrine: Vaginal
Teratogenic
Urinary tract

A 1992 Greenpeace report contains case studies on 5 dangerous pesticides, including this one, that have never been registered in the US but are made in the US for export. Greenpeace argues for an end to the loopholes which allow a double standard between domestic and export pesticides.

Body Weight Decrease (click on for all fluorinated pesticide)

Abstract: The developmental toxicity of haloxyfop-ethoxyethyl-ester (87237487) (HEE) was studied in rats. Pregnant Wistar-rats were gavaged with 5, 10, or 50mg/kg HEE on days six to 16 of gestation. They were observed for clinical signs of toxicity and sacrificed on gestational day 21. The uteri were removed, examined, and the number of implantations, live and dead fetuses, and resorption sites recorded. The live fetuses were weighed and examined for malformations. HEE at 10 and 50mg/kg caused vaginal bleeding in 40 and 50% of the dams, respectively. The 10 and 50mg/kg doses significantly increased the number of resorptions per litter and decreased the number of live fetuses per litter. The 50mg/kg dose caused a significant decrease in fetal weight. HEE caused a significant dose related increase in the number of cachectic fetuses. The proportion of cachectic fetuses following exposure to 5, 10, and 50mg/kg was 2.0, 6.8, and 20.3%, respectively. Ureterohydronephrosis was the most frequently observed soft tissue malformation, the prevalence of this defect following the 10 and 50mg/kg doses being 42.9 and 54.8%, respectively. The 10 and 50mg/kg doses caused skeletal malformations such as retarded ossification of the sternum and absence of rib 13. The author concludes that haloxyfop-ethoxyethyl-ester is embryotoxic and teratogenic. The no observable effect level is expected to be below 5mg/kg.
Ref: Machera K (1993). Developmental Toxicity of Haloxyfop Ethoxyethyl Ester in the Rat. Bulletin of Environmental Contamination and Toxicology, Vol. 51, No. 4, pages 625-632. As cited at Toxnet.

Definitions:
cachectic
- relating to or having the symptoms of cachexia
cachexia - A profound and marked state of constitutional disorder, general ill health and malnutrition. The loss of body weight and muscle mass frequently seen in patients with advanced diseases. Synonyms: cachexy, wasting

Bone (click on for all fluorinated pesticide)

Reproductive Effects: In rats, oral doses of 10 and 50 mg/kg/day of haloxyfop-ethoxyethyl from days 6 to 16 of pregnancy reduced the number of live offspring per litter and caused vaginal bleeding in the mother (5). Teratogenic Effects: Oral doses of 50 mg/kg/day of haloxyfop-ethoxyethyl in rats between days 6 and 16 of pregnancy caused developmental abnormalities in the offspring's urogenital system and death to the fetus (5). Oral doses of 7.5 mg/kg/day of haloxyfop-methyl given to rats from days 6 to 15 of pregnancy caused delayed bone formation in the offspring (6).
Ref: EXTOXNET Pesticide Information Profile

http://pmep.cce.cornell.edu/profiles/extoxnet/haloxyfop-methylparathion/haloxyfop-ext.html

Abstract: The developmental toxicity of haloxyfop-ethoxyethyl-ester (87237487) (HEE) was studied in rats. Pregnant Wistar-rats were gavaged with 5, 10, or 50mg/kg HEE on days six to 16 of gestation. They were observed for clinical signs of toxicity and sacrificed on gestational day 21. The uteri were removed, examined, and the number of implantations, live and dead fetuses, and resorption sites recorded. The live fetuses were weighed and examined for malformations. HEE at 10 and 50mg/kg caused vaginal bleeding in 40 and 50% of the dams, respectively. The 10 and 50mg/kg doses significantly increased the number of resorptions per litter and decreased the number of live fetuses per litter. The 50mg/kg dose caused a significant decrease in fetal weight. HEE caused a significant dose related increase in the number of cachectic fetuses. The proportion of cachectic fetuses following exposure to 5, 10, and 50mg/kg was 2.0, 6.8, and 20.3%, respectively. Ureterohydronephrosis was the most frequently observed soft tissue malformation, the prevalence of this defect following the 10 and 50mg/kg doses being 42.9 and 54.8%, respectively. The 10 and 50mg/kg doses caused skeletal malformations such as retarded ossification of the sternum and absence of rib 13. The author concludes that haloxyfop-ethoxyethyl-ester is embryotoxic and teratogenic. The no observable effect level is expected to be below 5mg/kg.
Ref: Machera K (1993). Developmental Toxicity of Haloxyfop Ethoxyethyl Ester in the Rat. Bulletin of Environmental Contamination and Toxicology, Vol. 51, No. 4, pages 625-632. As cited at Toxnet.

Cancer (click on for all fluorinated pesticide)

"Haloxyfop-( 2-etoxy-ethyl) 87237-48-7 Banned. Carcinogenic effects in mice even at very low doses. 1989."
Definition: "Banned. A substance which for health or environmental reasons by an authority decision is either no longer approved for any area of application, or for which an approval or registration has been denied from the first instance."

Ref: Euopean Commission. Appendix 5. Substances which may not be included as active ingredients in approved pesticide products, Chapter 15, Section 2, subsection one.

http://www.kemi.se/lagar_eng/pdf/app5_8.pdf

Embryotoxic (click on for all fluorinated pesticide)

Abstract: The developmental toxicity of haloxyfop-ethoxyethyl-ester (87237487) (HEE) was studied in rats. Pregnant Wistar-rats were gavaged with 5, 10, or 50mg/kg HEE on days six to 16 of gestation. They were observed for clinical signs of toxicity and sacrificed on gestational day 21. The uteri were removed, examined, and the number of implantations, live and dead fetuses, and resorption sites recorded. The live fetuses were weighed and examined for malformations. HEE at 10 and 50mg/kg caused vaginal bleeding in 40 and 50% of the dams, respectively. The 10 and 50mg/kg doses significantly increased the number of resorptions per litter and decreased the number of live fetuses per litter. The 50mg/kg dose caused a significant decrease in fetal weight. HEE caused a significant dose related increase in the number of cachectic fetuses. The proportion of cachectic fetuses following exposure to 5, 10, and 50mg/kg was 2.0, 6.8, and 20.3%, respectively. Ureterohydronephrosis was the most frequently observed soft tissue malformation, the prevalence of this defect following the 10 and 50mg/kg doses being 42.9 and 54.8%, respectively. The 10 and 50mg/kg doses caused skeletal malformations such as retarded ossification of the sternum and absence of rib 13. The author concludes that haloxyfop-ethoxyethyl-ester is embryotoxic and teratogenic. The no observable effect level is expected to be below 5mg/kg.
Ref: Machera K (1993). Developmental Toxicity of Haloxyfop Ethoxyethyl Ester in the Rat. Bulletin of Environmental Contamination and Toxicology, Vol. 51, No. 4, pages 625-632. As cited at Toxnet.

Definitions:
cachectic
- relating to or having the symptoms of cachexia
cachexia - A profound and marked state of constitutional disorder, general ill health and malnutrition. The loss of body weight and muscle mass frequently seen in patients with advanced diseases. Synonyms: cachexy, wasting

Endocrine: Vaginal (click on for all fluorinated pesticide)

Reproductive Effects: In rats, oral doses of 10 and 50 mg/kg/day of haloxyfop-ethoxyethyl from days 6 to 16 of pregnancy reduced the number of live offspring per litter and caused vaginal bleeding in the mother (5). Teratogenic Effects: Oral doses of 50 mg/kg/day of haloxyfop-ethoxyethyl in rats between days 6 and 16 of pregnancy caused developmental abnormalities in the offspring's urogenital system and death to the fetus (5). Oral doses of 7.5 mg/kg/day of haloxyfop-methyl given to rats from days 6 to 15 of pregnancy caused delayed bone formation in the offspring (6).
Ref: EXTOXNET Pesticide Information Profile

http://pmep.cce.cornell.edu/profiles/extoxnet/haloxyfop-methylparathion/haloxyfop-ext.html

Teratogenic (click on for all fluorinated pesticide)

Teratogenic Effects: Oral doses of 50 mg/kg/day of haloxyfop-ethoxyethyl in rats between days 6 and 16 of pregnancy caused developmental abnormalities in the offspring's urogenital system and death to the fetus (5). Oral doses of 7.5 mg/kg/day of haloxyfop-methyl given to rats from days 6 to 15 of pregnancy caused delayed bone formation in the offspring (6).
Ref: EXTOXNET Pesticide Information Profile

http://pmep.cce.cornell.edu/profiles/extoxnet/haloxyfop-methylparathion/haloxyfop-ext.html

Abstract: The developmental toxicity of haloxyfop-ethoxyethyl-ester (87237487) (HEE) was studied in rats. Pregnant Wistar-rats were gavaged with 5, 10, or 50mg/kg HEE on days six to 16 of gestation. They were observed for clinical signs of toxicity and sacrificed on gestational day 21. The uteri were removed, examined, and the number of implantations, live and dead fetuses, and resorption sites recorded. The live fetuses were weighed and examined for malformations. HEE at 10 and 50mg/kg caused vaginal bleeding in 40 and 50% of the dams, respectively. The 10 and 50mg/kg doses significantly increased the number of resorptions per litter and decreased the number of live fetuses per litter. The 50mg/kg dose caused a significant decrease in fetal weight. HEE caused a significant dose related increase in the number of cachectic fetuses. The proportion of cachectic fetuses following exposure to 5, 10, and 50mg/kg was 2.0, 6.8, and 20.3%, respectively. Ureterohydronephrosis was the most frequently observed soft tissue malformation, the prevalence of this defect following the 10 and 50mg/kg doses being 42.9 and 54.8%, respectively. The 10 and 50mg/kg doses caused skeletal malformations such as retarded ossification of the sternum and absence of rib 13. The author concludes that haloxyfop-ethoxyethyl-ester is embryotoxic and teratogenic. The no observable effect level is expected to be below 5mg/kg.
Ref: Machera K (1993). Developmental Toxicity of Haloxyfop Ethoxyethyl Ester in the Rat. Bulletin of Environmental Contamination and Toxicology, Vol. 51, No. 4, pages 625-632. As cited at Toxnet.

Urinary Tract (click on for all fluorinated pesticide)

Reproductive Effects: In rats, oral doses of 10 and 50 mg/kg/day of haloxyfop-ethoxyethyl from days 6 to 16 of pregnancy reduced the number of live offspring per litter and caused vaginal bleeding in the mother (5). Teratogenic Effects: Oral doses of 50 mg/kg/day of haloxyfop-ethoxyethyl in rats between days 6 and 16 of pregnancy caused developmental abnormalities in the offspring's urogenital system and death to the fetus (5). Oral doses of 7.5 mg/kg/day of haloxyfop-methyl given to rats from days 6 to 15 of pregnancy caused delayed bone formation in the offspring (6).
Ref: EXTOXNET Pesticide Information Profile
http://pmep.cce.cornell.edu/profiles/extoxnet/haloxyfop-methylparathion/haloxyfop-ext.html

 
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