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Abstracts

Activity: Rodenticide

Structure

Gliftor Systematic Name: 2-Propanol, 1-chloro-3-fluoro-, mixt. with 1,3-difluoro-2-propanol CAS No. 8065-71-2	1,3-Difluoro-2-propanol CAS No. 453-13-4	2-Propanol, 1-chloro-3-fluoro- CAS No. 453-11-2

Note: There is little information available.

Adverse Effects:
Blood
Brain
CNS
Kidney
Liver
Lung
Spleen

"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982, Vol. -, Pg. 71, 1982. (From ChemIDplus at Toxnet)
Organism	Test Type	Route	Reported Dose (Normalized Dose)
mammal (species unspecified)	LD50	oral	165mg/kg (165 mg/kg)
mouse	LC50	inhalation	1260mg/m3/2H (1260 mg/kg)
mouse	LD50	oral	165mg/kg (165 mg/kg)
rabbit	LD50	oral	7600ug/kg (7.6 mg/kg)
rat	LC50	inhalation	580mg/m3/4H (580 mg/kg)
rat	LD50	oral	96mg/kg (96 mg/kg)
rat	LD50	skin	66mg/kg (66 mg/kg)

Blood (click on for all fluorinated pesticides)

Abstract. Rats were subjected to chronic inhalation of gliftor (I; 110, 64, 13, and 1 mg/m-3). A dose of 110 mg/m-3 beginning with the 30th day of poisoning caused pronounced leukocytosis (maximum on the 72nd day), eosinophilia, and lymphopenia. The contents of Hb, erythrocytes, and monocytes were close to the control values. A dose of 64 mg/m-3 caused less leukocytosis and insignificant changes of the content of neutrophils and lymphocytes. With a dose of 1 mg/m-3 there was a significant increase of the relative number of eosinophils and decrease of the number of lymphocytes. This dose was considered the threshold. With single cutaneous applications the LD5- for rabbits was 66 plus or minus 10 mg/kg. The recommended maximum allowable concentration of I for worker exposure in the air of production rooms in 0.05 mg/m-3 (1/20 of the threshold value).
Ref: Change of the morphological composition of the peripheral blood in gliftor poisoning; by TKACH NZ, MILOVANOVA VI, KNYSH VS. TR INST KRAEV PATOL AKAD NAUK KAZ SSR; 22 1971 12-16. [Abstract from Toxline at Toxnet.]

• Definition: Leukocytosis is a condition characterized by an elevated number of white cells in the blood.

Abstract. Under conditions of the acute inhalation effect of the vapors of gliftor (I) the LD50 for rats was 580 plus or minus 65 and for mice 1260 plus or minus 15 mg/m-3. The threshold concentration (TC) for rats with respect to brief disturbance of the functional state of the CNS was 50 and the subthreshold 10 mg/m-3; for mice the TC was 190 mg/m-3. Chronic (4 mo.) inhalation by rats of I in a concentration of 110 and 64 mg/m-3 disturbed the functional state of the CNS and antitoxic and protein-forming functions of the liver and reduced oxidation-reduction processes. I in a concentration of 1.0 mg/m-3 increased the concent of eosinophils and reduced the number of lymphocytes by the end of the poisoning period. I is a hazardous compound. A maximum allowable concentration of I of 0.05 mg/m-3 in the air of production shops is recommended for worker exposure.
Ref: Effect of gliftor on certain metabolic processes of experimental animals under inhalation poisoning conditions; by TKACH NZ, KNYSH VS, MILOVANOVA VI, SHISHKOVA NK, SLEPOVA LI. TR INST KRAEV PATOL AKAD NAUK KAZ SSR; 22 1971 5-12. [Abstract from Toxline at Toxnet.]

Abstract. The threshold concentration with respect to the effect of gliftor (I) on the organoleptic properties of water is at the 1 mg/l level. I has feeble cumulative properties. Rabbits tolerated the chronic oral administration with water of 1/10 and 1/20 LD50 of I, receiving in all 11.2-5.6 LD50. In this case leukocytosis, an increase of the quantity of coproporphyrin excreted in the urine, and an increase of the blood nucleic acid level were noted. The threshold dose is close to 0.15 mg/mg (3.0 mg/l). The organoleptic sign is the limiting factor in establishing the maximum allowable concentration of I in water.
Ref: Effect of gliftor on rabbits under conditions of chronic oral poisoning; by ALIEV KA, TKACH NZ, SHISHKOVA NK, KOLOD'KO TP. TR INST KRAEV PATOL AKAD NAUK KAZ SSR; 22 1971 17-23. [Abstract from Toxline at Toxnet.]

Brain (click on for all fluorinated pesticides)

Abstract. Acute poisoning with gliftor, a pesticide composed of 30% glycerol chlorofluorohydrin and 70% glycerol difluorohydrin, was studied in three tractor drivers who, mistaking it for alcohol, ingested 30 ml each of this liquid. Motor disorders comprising complex chloreiform hyperkinesis (Kulenkampff-Tarnow syndrome) due to lesions in the cortical and subcortical structures of the corpus striatum and of the limbicoreticular portion of the brain, were the principal poisoning symptoms. There were no symptoms of fluorine poisoning. One patient, who presented the first symptoms 48 hr after ingestion of the poison, died in respiratory collapse 6 days later. Leukocytosis (up to 20% rod neutrophilis) hyperglycemia, a serum potassium level of 2.7 mEq/liter, proteinuria, pyuria, and hematuria were observed. Histopathological examination revealed acute circulatory disturbances in the internal organs, parenchymatous dystrophy, and dystrophic changes in the central nervous system.
Ref: Three cases of gliftor poisoning; by Kovalenko LI, Bulkina VA, Panteleev RI. Gig. Tr. Prof. Zabol. (12): 53-54; 1975. [Abstract from Toxline at Toxnet.]

CNS (click on for all fluorinated pesticides)

Abstract. Acute poisoning with gliftor, a pesticide composed of 30% glycerol chlorofluorohydrin and 70% glycerol difluorohydrin, was studied in three tractor drivers who, mistaking it for alcohol, ingested 30 ml each of this liquid. Motor disorders comprising complex chloreiform hyperkinesis (Kulenkampff-Tarnow syndrome) due to lesions in the cortical and subcortical structures of the corpus striatum and of the limbicoreticular portion of the brain, were the principal poisoning symptoms. There were no symptoms of fluorine poisoning. One patient, who presented the first symptoms 48 hr after ingestion of the poison, died in respiratory collapse 6 days later. Leukocytosis (up to 20% rod neutrophilis) hyperglycemia, a serum potassium level of 2.7 mEq/liter, proteinuria, pyuria, and hematuria were observed. Histopathological examination revealed acute circulatory disturbances in the internal organs, parenchymatous dystrophy, and dystrophic changes in the central nervous system.
Ref: Three cases of gliftor poisoning; by Kovalenko LI, Bulkina VA, Panteleev RI. Gig. Tr. Prof. Zabol. (12): 53-54; 1975. [Abstract from Toxline at Toxnet.]

Abstract. Under conditions of the acute inhalation effect of the vapors of gliftor (I) the LD50 for rats was 580 plus or minus 65 and for mice 1260 plus or minus 15 mg/m-3. The threshold concentration (TC) for rats with respect to brief disturbance of the functional state of the CNS was 50 and the subthreshold 10 mg/m-3; for mice the TC was 190 mg/m-3. Chronic (4 mo.) inhalation by rats of I in a concentration of 110 and 64 mg/m-3 disturbed the functional state of the CNS and antitoxic and protein-forming functions of the liver and reduced oxidation-reduction processes. I in a concentration of 1.0 mg/m-3 increased the concent of eosinophils and reduced the number of lymphocytes by the end of the poisoning period. I is a hazardous compound. A maximum allowable concentration of I of 0.05 mg/m-3 in the air of production shops is recommended for worker exposure.
Ref: Effect of gliftor on certain metabolic processes of experimental animals under inhalation poisoning conditions; by TKACH NZ, KNYSH VS, MILOVANOVA VI, SHISHKOVA NK, SLEPOVA LI. TR INST KRAEV PATOL AKAD NAUK KAZ SSR; 22 1971 5-12. [Abstract from Toxline at Toxnet.]

Kidney (click on for all fluorinated pesticides)

Abstract. Rats were subjected to the single inhalation effect of vapors of the zoocide gliftor (I; 50, 100, 350, 520, and 1100 mg/m-3). Morphological changes were noted beginning with a concentration of 350 mg/m-3. In a chronic experiment (4 mo.) the rats were subjected to I poisoning in a concentration of 10, 13, 64, and 110 mg/m-3. Distinct morphological changes in the organs were noted under the effect of concentrations 64 and 110 mg/m-3. Under the chronic effect of I there were considerable circulatory disorders and destructive changes of the interanl organs, especially in the liver, lungs, spleen, and kidneys.
Ref: Pathomorphological changes in internal organs of white rats under the inhalation effect of gliftor; by KNYSH VS, TKACH NZ, TSAREVSKII LP, MILOVANOVA VI. TR INST KRAEV PATOL AKAD NAUK KAZ SSR; 22 1971 23-28. [Abstract from Toxline at Toxnet.]

Liver (click on for all fluorinated pesticides)

Abstract. Rats were subjected to the single inhalation effect of vapors of the zoocide gliftor (I; 50, 100, 350, 520, and 1100 mg/m-3). Morphological changes were noted beginning with a concentration of 350 mg/m-3. In a chronic experiment (4 mo.) the rats were subjected to I poisoning in a concentration of 10, 13, 64, and 110 mg/m-3. Distinct morphological changes in the organs were noted under the effect of concentrations 64 and 110 mg/m-3. Under the chronic effect of I there were considerable circulatory disorders and destructive changes of the interanl organs, especially in the liver, lungs, spleen, and kidneys.
Ref: Pathomorphological changes in internal organs of white rats under the inhalation effect of gliftor; by KNYSH VS, TKACH NZ, TSAREVSKII LP, MILOVANOVA VI. TR INST KRAEV PATOL AKAD NAUK KAZ SSR; 22 1971 23-28. [Abstract from Toxline at Toxnet.]

Lung (click on for all fluorinated pesticides)

Abstract. The single administration of gliftor (I; internally, 40-160 mg/kg) caused considerable destructive changes and circulatory disorders in the internal organs of rats. The maximum tolerance dose of I (60 mg/kg) caused hyperplasia of the cells of the RES in the spleen, proliferation of local cells, and inflammatory cellular infiltration of the alveolar walls in the lungs.
Ref: Morphological changes of internal organs of experimental animals after oral administration of gliftor; by KNYSH VS, TKACH NZ, TSAREVSKII LP. TR INST KRAEV PATOL AKAD NAUK KAZ SSR; 22 1971 28-30. [Abstract from Toxline at Toxnet.]

Abstract. Rats were subjected to the single inhalation effect of vapors of the zoocide gliftor (I; 50, 100, 350, 520, and 1100 mg/m-3). Morphological changes were noted beginning with a concentration of 350 mg/m-3. In a chronic experiment (4 mo.) the rats were subjected to I poisoning in a concentration of 10, 13, 64, and 110 mg/m-3. Distinct morphological changes in the organs were noted under the effect of concentrations 64 and 110 mg/m-3. Under the chronic effect of I there were considerable circulatory disorders and destructive changes of the interanl organs, especially in the liver, lungs, spleen, and kidneys.
Ref: Pathomorphological changes in internal organs of white rats under the inhalation effect of gliftor; by KNYSH VS, TKACH NZ, TSAREVSKII LP, MILOVANOVA VI. TR INST KRAEV PATOL AKAD NAUK KAZ SSR; 22 1971 23-28. [Abstract from Toxline at Toxnet.]

Spleen (click on for all fluorinated pesticides)

Abstract. The single administration of gliftor (I; internally, 40-160 mg/kg) caused considerable destructive changes and circulatory disorders in the internal organs of rats. The maximum tolerance dose of I (60 mg/kg) caused hyperplasia of the cells of the RES in the spleen, proliferation of local cells, and inflammatory cellular infiltration of the alveolar walls in the lungs.
Ref: Morphological changes of internal organs of experimental animals after oral administration of gliftor; by KNYSH VS, TKACH NZ, TSAREVSKII LP. TR INST KRAEV PATOL AKAD NAUK KAZ SSR; 22 1971 28-30. [Abstract from Toxline at Toxnet.]

Abstract. Rats were subjected to the single inhalation effect of vapors of the zoocide gliftor (I; 50, 100, 350, 520, and 1100 mg/m-3). Morphological changes were noted beginning with a concentration of 350 mg/m-3. In a chronic experiment (4 mo.) the rats were subjected to I poisoning in a concentration of 10, 13, 64, and 110 mg/m-3. Distinct morphological changes in the organs were noted under the effect of concentrations 64 and 110 mg/m-3. Under the chronic effect of I there were considerable circulatory disorders and destructive changes of the interanl organs, especially in the liver, lungs, spleen, and kidneys.
Ref: Pathomorphological changes in internal organs of white rats under the inhalation effect of gliftor; by KNYSH VS, TKACH NZ, TSAREVSKII LP, MILOVANOVA VI. TR INST KRAEV PATOL AKAD NAUK KAZ SSR; 22 1971 23-28. [Abstract from Toxline at Toxnet.]