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Abstracts

Activity: Herbicide
Structure:


Adverse Effects:
Bone
Endocrine: Adrenal
Endocrine: Testicular
Kidney
Environmental

Bone (click on for all fluorinated pesticides)

Abstract: The objective of this study was to assess the maternal and developmental toxicity potential of fluroxypyr methylheptyl ester (FMHE) in rats. Groups of 28 Sprague-Dawley rats received 0 (corn oil vehicle), 100, 300, or 600 mg/kg/day of FMHE via gavage on gestation days 6-15. In-life parameters evaluated included clinical signs of toxicity, feed consumption, body weights and body weight gains. On gestation day 20, all surviving females were euthanized and examined for gross pathologic changes and alterations in liver, kidney and gravid uterus weights. The number of corpora lutea, implantations and resorptions was determined. The fetuses were removed, weighed, sexed and examined for external, visceral and skeletal alterations. At 600 mg/kg/day, eight rats (29%) died prior to the scheduled necropsy. No specific treatment-related gross pathological lesions were found. Decreased body weight gain, slightly decreased feed consumption and an increased incidence of anogenital staining also were noted at this dose level. No signs of maternal toxicity were observed in rats given 100 or 300 mg/kg/day. In the fetuses obtained from the 600 mg/kg/day group, several skeletal variations (delayed ossification) occurred with increased incidence. Despite the severity of the maternal toxicity at this dose level, there were no other signs of developmental toxicity, nor were there any adverse effects of treatment on any other developmental parameters at the 100 or 300 mg/kg/day dose levels. Thus, the no-observed-effect-level (NOEL) for maternal and developmental toxicity was 300 mg/kg/day.
Ref: Carney EW et al. (1995). Developmental toxicity study in rats with fluroxypyr methylheptyl ester. Author Address: Toxicology Research Laboratory, Dow Chemical Co., Midland, MI. Source: Teratology; Mar;51(3):180. Abstract from Toxnet.

Endocrine: Adrenal (click on for all fluorinated pesticides)

Reproductive toxicity study. In the 2-generation reproductive toxicity study in rats, the maternal (systemic) NOAEL was 100 mg/kg/ day, based on increased kidney weights and kidney histopathology at the LOAEL of 500 mg/kg/day. The developmental (pup) NOAEL was 500 mg/kg/ day, based on decreased body weight at the LOAEL of 1,000 mg/kg/day. The reproductive NOAEL was 1,000 mg/kg/day (HDT).... Chronic dietary all populations: 28-day dog range- finding feeding study LOAEL = 150 mg/kg/day based on histopathological lesions in the kidneys, decreased testes weights, and increased adrenal weights in both sexes...
Ref: Federal Register. September 17, 2001. Fluroxypyr 1-Methylheptyl Ester; Pesticide Tolerances for Emergency Exemptions. Final Rule.
http://www.fluoridealert.org/pesticides/Fluroxypyr.FR.Sept.17.2001.htm

Endocrine: Testicular (click on for all fluorinated pesticides)

Reproductive toxicity study. In the 2-generation reproductive toxicity study in rats, the maternal (systemic) NOAEL was 100 mg/kg/ day, based on increased kidney weights and kidney histopathology at the LOAEL of 500 mg/kg/day. The developmental (pup) NOAEL was 500 mg/kg/ day, based on decreased body weight at the LOAEL of 1,000 mg/kg/day. The reproductive NOAEL was 1,000 mg/kg/day (HDT).... Chronic dietary all populations: 28-day dog range- finding feeding study LOAEL = 150 mg/kg/day based on histopathological lesions in the kidneys, decreased testes weights, and increased adrenal weights in both sexes...
Ref: Federal Register. September 17, 2001. Fluroxypyr 1-Methylheptyl Ester; Pesticide Tolerances for Emergency Exemptions. Final Rule.
http://www.fluoridealert.org/pesticides/Fluroxypyr.FR.Sept.17.2001.htm

Kidney (click on for all fluorinated pesticides)

Reproductive toxicity study. In the 2-generation reproductive toxicity study in rats, the maternal (systemic) NOAEL was 100 mg/kg/ day, based on increased kidney weights and kidney histopathology at the LOAEL of 500 mg/kg/day. The developmental (pup) NOAEL was 500 mg/kg/ day, based on decreased body weight at the LOAEL of 1,000 mg/kg/day. The reproductive NOAEL was 1,000 mg/kg/day (HDT).... Chronic dietary all populations: 28-day dog range- finding feeding study LOAEL = 150 mg/kg/day based on histopathological lesions in the kidneys, decreased testes weights, and increased adrenal weights in both sexes...
Ref: Federal Register. September 17, 2001. Fluroxypyr 1-Methylheptyl Ester; Pesticide Tolerances for Emergency Exemptions. Final Rule.
http://www.fluoridealert.org/pesticides/Fluroxypyr.FR.Sept.17.2001.htm

Metabolite toxicology. Administration of fluroxypyr, as the acid or methylheptyl ester in a variety of toxicological studies, has produced similar effects. The principal response to sufficiently high dosages, whether administered over the short-term or, in some cases, over a lifetime, was nephrosis.
Ref: Federal Register: May 14, 2003 (Volume 68, Number 93)] [Notices] [Page 25883-25888]. Fluroxypyr; Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on Food
http://www.fluorideaction.org/pesticides/fluroxypyr.fr.may.14.2003.htm

870.4300 Carcinogenicity--Rats NOAEL = 100 mg/kg/day. LOAEL = 500 mg/kg/day based on chronic progressive kidney glomerulonephropathy (M&F).(no) evidence of carcinogenicity.
Ref: Federal Register. December 31, 2003. Fluroxypyr; Pesticide Tolerance. Final Rule.
http://www.epa.gov/fedrgstr/EPA-PEST/2003/December/Day-31/p32007.htm