|
Return
to Index Page
Activity:
Herbicide
(unclassified)
Structure
for "Flumiclorac"
Adverse
Effects:
Blood
Kidney
Liver
Phototoxic
Environmental
•
Very little toxicological data is available for this herbicide.
•
As of February 14, 2005, this herbicide is permitted in
or on 5 food commodities
in the United States - see list at bottom of page.
|
Blood
(click
on for all fluorinated pesticides)
-- Chronic
Toxicity (Including Cancer): Studies with Flumiclorac Pentyl Technical
indicate that repeated high exposures produced changes in
liver, kidney, and red blood cells
but did not produce cancer in test animals.
-- Potentially Aggravated Condition: Individuals with preexisting
diseases of the liver, kidney, or red
blood cells may have increased susceptibility to the toxicity
of excessive exposures.
-- SUBCHRONIC: Compound-related effects noted at very high dose
levels of Flumiclorac Pentyl Technical in rodents and/or dogs
included: increased liver and kidney weights;
histological changes in the kidney and liver;
slight changes in blood biochemistry parameters; decreased red
blood cell count, hemoglobin, and hematocrit; and slight
decreases in body weight. The NOEL in rats and mice was 1000 ppm.
-- CHRONIC/CARCINOGENICITY: Effects of long-term high dose exposures
to Flumiclorac Pentyl Technical in rodents and/or dogs consisted
primarily of increases in kidney and liver
weights, slight changes in blood
biochemistry, and histological changes in
the liver. The lowest NOEL
was 300 ppm in the mouse study. Flumiclorac Pentyl Technical was
not carcinogenic in either rats or mice.
Ref: Material Safety Data Sheet
for RESOURCE TM Herbicide.
http://www.horizononline.com/MSDS_Sheets/529.txt
Kidney
(click
on for all fluorinated pesticides)
In the rat, the kidney is a potential target organ at high dose
levels. Effects included urinary incontinence, increased water
consumption, increased urine volume, and increased kidney weights
in the females, and increased squamous epithelial cells in urinary
sediment and increased kidney weights in the males. Nephropathy
was evident in male rats in a two-generation reproduction study
following administration of high dose levels.
Reference: June 28, 2005. US EPA. Health
Effects Division Chapter of the Tolerance Reassessment Eligibility
Decision Document (TRED).
http://www.fluorideaction.org/pesticides/flumiclorac-p.opp-2005-0229-0003.pdf
-- Chronic
Toxicity (Including Cancer): Studies with Flumiclorac Pentyl Technical
indicate that repeated high exposures produced changes in
liver, kidney, and
red blood cells but did not
produce cancer in test animals.
-- Potentially Aggravated Condition: Individuals with preexisting
diseases of the liver, kidney, or
red blood cells may have increased
susceptibility to the toxicity of excessive exposures.
-- SUBCHRONIC: Compound-related effects noted at very high dose
levels of Flumiclorac Pentyl Technical in rodents and/or dogs
included: increased liver and kidney
weights; histological changes in the kidney and
liver; slight changes in blood biochemistry parameters; decreased
red blood cell count, hemoglobin, and hematocrit;
and slight decreases in body weight. The NOEL in rats and
mice was 1000 ppm.
-- CHRONIC/CARCINOGENICITY: Effects of long-term high dose exposures
to Flumiclorac Pentyl Technical in rodents and/or dogs consisted
primarily of increases in kidney
and liver weights, slight changes
in blood biochemistry, and histological changes in the liver.
The lowest NOEL was 300 ppm in the mouse study. Flumiclorac Pentyl
Technical was not carcinogenic in either rats or mice.
Ref: Material
Safety Data Sheet for RESOURCE TM Herbicide.
http://www.fluoridealert.org/pesticides/Flumiclorac-pentyl.MSDS.htm
Liver
(click
on for all fluorinated pesticides)
-- Chronic
Toxicity (Including Cancer): Studies with Flumiclorac Pentyl Technical
indicate that repeated high exposures produced changes in
liver, kidney, and red blood cells
but did not produce cancer in test animals.
-- Potentially Aggravated Condition: Individuals with preexisting
diseases of the liver, kidney,
or red blood cells may have
increased susceptibility to the toxicity of excessive exposures.
-- SUBCHRONIC: Compound-related effects noted at very high dose
levels of Flumiclorac Pentyl Technical in rodents and/or dogs
included: increased liver and
kidney weights; histological changes in the kidney and liver;
slight changes in blood biochemistry parameters; decreased red
blood cell count, hemoglobin, and hematocrit;
and slight decreases in body weight. The NOEL in rats and mice
was 1000 ppm.
-- CHRONIC/CARCINOGENICITY: Effects of long-term high dose exposures
to Flumiclorac Pentyl Technical in rodents and/or dogs consisted
primarily of increases in kidney and liver
weights, slight changes in blood
biochemistry, and histological changes
in the liver. The lowest NOEL was 300 ppm in the mouse
study. Flumiclorac Pentyl Technical was not carcinogenic in either
rats or mice.
Ref: Material
Safety Data Sheet for RESOURCE TM Herbicide.
http://www.fluoridealert.org/pesticides/Flumiclorac-pentyl.MSDS.htm
| Environmental
(click on for all fluorinated
pesticides)
Phototoxic
Pesticide. Light-dependent peroxidizing
herbicides (LDPHs). US EPA identified the following
fluorinated herbicides - Acifluorfen,
Azafenidin, Carfentrazone-ethyl, Flumiclorac-penty,
Flumioxazin, Fluthiacet-methyl, Fomesafen,
Lactofen, Oxadiargyl, Oxadiazon, Oxyfluorfen, Sulfentrazone,
Thidiazimin as phototoxic pesticides
that act by inhibiting protoporphyringen oxidase
in the heme and chlorophyll biosynthetic pathway.
[10 out of the 13 pesticides that EPA identified are fluorinated
pesticides].
SEE http://www.fluoridealert.org/pesticides/PHOTOTOXICITY.PAGE.htm
Ref: December 11, 2001 - US EPA. Revised
Environmental Fate and Effects Division Preliminary Risk
Assessment for the Oxyfluorfen Reregistration Eligibility
Decision Document (also at: http://www.epa.gov/oppsrrd1/reregistration/oxyfluorfen/oxyefedchap.pdf
An aquatic
phototoxicity study is being required for light-dependent
peroxidizing herbicides, including flumiclorac pentyl. Note:
This is a new data requirement and will be required under
a group DCI for Light-Dependent Peroxidizing Herbicides
to be sent under separate cover - (page 7).
Ref: August 23, 2005: Report of the
Food Quality Protection Act (FQPA) Tolerance Assessment
Progress and Risk Management Decision (TRED). Federal Regiser
Docket No. OPP-2005-0229-0002.
http://www.fluorideaction.org/pesticides/flumiclorac-p.opp-2005-0229-0002.pdf
|
A
February 14, 2005, check at the Code
of Federal Regulations for Flumiclorac pentyl: this herbicide
is permitted in or on 5
food commodities
in the United States. The
following list identifies these crops for which EPA has set
pesticide tolerances. |
| [Code
of Federal Regulations]
[Title 40, Volume 22]
[Revised as of July 1, 2004]
From the U.S. Government Printing Office via GPO Access
[CITE: 40CFR180.477]
[Page 470-471]
TITLE 40--PROTECTION OF ENVIRONMENT
CHAPTER I--ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)
PART 180_TOLERANCES AND EXEMPTIONS FROM TOLERANCES FOR PESTICIDE
CHEMICALS
IN FOOD--Table of Contents
Subpart C_Specific Tolerances
Sec. 180.477 Flumiclorac pentyl; tolerances for residues.
(a) General. Tolerances are established for
residues of the
herbicide flumiclorac pentyl, pentyl[2-chloro-4-fluoro-5-(1,3,4,5,6,7-
hexahydro-1,3-dioxo-2H-isoindol-2-yl)phenoxy]acetate, including
all the
metabolites of flumiclorac pentyl, in or on the food
commodities listed
below. The tolerance level for each commodity is expressed
in terms of
the parent only which serves as an indicator of the use
of flumiclorac pentyl on these food commodities. |
| Crop |
Parts
per Million |
| Corn, field,
forage |
0.01
|
| Corn, field,
grain |
0.01
|
| Corn, field,
stover |
0.01
|
| Soybean,
hulls |
0.02 |
| Soybean,
seed |
0.01
|
| (b)
Section 18 emergency exemptions. [Reserved]
(c) Tolerances with regional registrations. [Reserved]
(d) Indirect or inadvertent residues. [Reserved] |
|
