Return to
Index Page
ACTIVITY: Herbicide
(sulfonylurea)
CAS Name: N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-3-(trifluoromethyl)-2-pyridinesulfonamide
Structure:
Adverse Effects:
Bone
Kidney
Liver
Reproductive/Developmental
Bone (click on
for all fluorinated pesticides)
• Target / critical effect - Developmental toxicity: Developmental
effects at maternal toxic doses (foetal mortality, reduced foetal
weight, skeletal variations) in rats.
Lowest relevant developmental NOAEL / 100 mg/kgbw/day.
Kidney
(click on for all
fluorinated pesticides)
• Long term toxicity and carcinogenicity . Target / critical
effect: Liver (centrolobulillar hypertrophy)
in mice and kidney (chronic nephropathy)
in rats. Lowest relevant NOAEL: 1.3mg/kg bw/day: 2-years
rats. No evidence for carcinogenic potential.
Liver
(click on for all
fluorinated pesticides)
• Short term toxicity Target / critical effect: Liver
(centrolobulillar hepatocyte hypertrophy).
Lowest relevant oral NOAEL / NOEL: 2 mg/kg bw/day, 13-week dogs
and 1-year dogs.
• Long term toxicity and carcinogenicity . Target / critical
effect: Liver (centrolobulillar hypertrophy)
in mice and kidney (chronic nephropathy) in rats. Lowest
relevant NOAEL: 1.3mg/kg bw/day: 2-years rats. No evidence for
carcinogenic potential.
Reproductive
/ Developmental
(click on for all fluorinated pesticides)
• Target / critical effect - Developmental toxicity: Developmental
effects at maternal toxic doses (foetal
mortality, reduced foetal weight, skeletal variations) in rats.
Lowest relevant developmental NOAEL / 100 mg/kgbw/day.
|