Adverse Effects
Flazasulfuron
CAS No. 104040-78-0
 
 

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ACTIVITY: Herbicide (sulfonylurea)

CAS Name: N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-3-(trifluoromethyl)-2-pyridinesulfonamide

Structure:


Adverse Effects:
Bone
Kidney
Liver
Reproductive/Developmental


Bone
(click on for all fluorinated pesticides)

• Target / critical effect - Developmental toxicity: Developmental effects at maternal toxic doses (foetal mortality, reduced foetal weight, skeletal variations) in rats. Lowest relevant developmental NOAEL / 100 mg/kgbw/day.

Kidney (click on for all fluorinated pesticides)

• Long term toxicity and carcinogenicity . Target / critical effect: Liver (centrolobulillar hypertrophy) in mice and kidney (chronic nephropathy) in rats. Lowest relevant NOAEL: 1.3mg/kg bw/day: 2-years rats. No evidence for carcinogenic potential.

Liver (click on for all fluorinated pesticides)

• Short term toxicity Target / critical effect: Liver (centrolobulillar hepatocyte hypertrophy). Lowest relevant oral NOAEL / NOEL: 2 mg/kg bw/day, 13-week dogs and 1-year dogs.
• Long term toxicity and carcinogenicity . Target / critical effect: Liver (centrolobulillar hypertrophy) in mice and kidney (chronic nephropathy) in rats. Lowest relevant NOAEL: 1.3mg/kg bw/day: 2-years rats. No evidence for carcinogenic potential.

Reproductive / Developmental (click on for all fluorinated pesticides)

• Target / critical effect - Developmental toxicity: Developmental effects at maternal toxic doses (foetal mortality, reduced foetal weight, skeletal variations) in rats. Lowest relevant developmental NOAEL / 100 mg/kgbw/day.

 
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