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fluorohydrin Index Page
Activity: Rodenticide
Structure:
Adverse Effects:
Bone
Endocrine: Uterus
Heart
Kidney
Teratogen
Ethylene
fluorohydrin is a liquid fluoro alcohol compound which is
miscible in water. Little specific data were available specifically
about the toxicity of ethylene fluorohydrin; its toxicity
is expected to be similar to that of FLUOROACETATE, as it
is oxidized to fluoroacetate by tissue alcohol dehydrogenase.
Ethylene fluorohydrin may be absorbed following ingestion,
inhalation, or dermal contact. It is used as a rodenticide,
although it is not registered for use as a pesticide in
the US.
Mechanism
of Action: The fluoroacetate ion is not poisonous itself
but is converted to fluorocitric acid, which blocks the
tricarboxylic acid cycle, an essential mechanism of energy
production in mammalian cells ... This manifests itself
principally in disturbed activities of the central nervous
system and of the heart. [Gosselin,
R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial
Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p.
III-194]
Ref:
Ethylene fluorohydrin. TOXNET profile from Hazardous Substances
Data Base.
http://www.fluorideaction.org/pesticides/ethylene.fluorohydri.toxnet.htm
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Bone
• Endocrine:
Uterus •
Kidney
•
Heart
• Teratogen
•
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for all fluorinated pesticides)
Source: Teratology
1992 May;45(5):463
Teratogenic
effects of the halogenated ethanol 2-fluoro ethanol in Long Evans
rats.
Authors: Mankes RF,
Lefevre R, Calvano CJ
Author Address: Department
of Pharmacology and Toxicology, Albany Medical College, Albany,
NY.
Abstract:
The 2 substituted halo ethanols (e.g., 2-chloro ethanol-ethylene
chlorohydrin-ECH, 2-bromo ethanol-ethylene bromohydrin-EBH, 2-fluoro
ethanol-ethylene fluorohydrin-EFH)
are contaminants of gas-sterilized foods and medical devices (EBH,
ECH) and common industrial reagents (ECH, EBH, EFH). In a continuing
effort to define the teratogenic potential of substituted ethanols,
pregnant Long-Evans rats were given EFH
(0.06, 0.36, and 0.6 mg/kg -I.G.)
or water (20 ml/kg-isovolumetric vehicle control) from day 6 to
day 15 of gestation. All dams were given lab chow and water ad
libitum. Body weights were monitored during gestation. On gestation
day 20, the dams were euthanized by halothane overdose and the
products of conception examined according to Manson and Kang (1989).
Soft tissue defects were evaluated
by the free hand slice technique of Wilson (1965) and defects
in skeletal development were assessed by the simultaneous
double staining technique of McLeod (1980). Significance was set
at P less than 0.05 (Yates X2 test). An increase in sternebral
ossification defects were present in all experimental groups.
Hydronephrosis was evident in the two highest doses. The
high dose group had significant incidences
of runting (pup weight less than 2.7 g) and variant
rib ossifications. Cardiac septal
defects appeared in the hearts of pups of the 0.36 mg/kg
group. Pups of dams given 0.06 mg/kg of EFH revealed the presence
of extra vertebral ossification centers.
In the high dose group alone, intrauterine
growth retardation was evident based on decreased
pup weight (P less than 0.05, corrected T-test). There
were no significant changes in either dam or gestational weight
gain observed. Overall, the percentage of implantations resulting
in malformed or dead pups in response
to oral administration of EFH increases
significantly in a dose-related manner with increasing alcohol
concentrations.
Ref: Mankes RF et al. (1992).
Teratogenic effects of the halogenated ethanol 2-fluoro ethanol
in Long Evans rats. Teratology 1992 May;45(5):463 as cited by
Toxnet.
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Definition
HYDRONEPHROSIS - Pathological
chronic enlargement of the collecting channels of a kidney, leading
to compression and eventual destruction of kidney tissue, and
diminishing kidney functionning.
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