Adverse Effects
Diflufenzopyr
CAS No. 109293-97-2
 
 

Return to Diflufenzopyr Index Page

Activity: Herbicide (urea)
Structure:

Adverse Effects:
Anemia
Body Weight Decrease
Bone
Brain
Endocrine: Testicular
Endocrine: Thymus
Kidney
Lung
Spleen
Environmental

As of February 14, 2005, this herbicide is permitted in or on 31 food commodities in the United States - see list at bottom of page.


Anemia
(click on for all fluorinated pesticides)

Dietary exposure. EPA has established the reference dose (RfD) for diflufenzopyr at 0.26 milligrams/kilogram/day (mg/kg/day). This RfD is based on bone marrow compensated hemolytic anemia observed in the 1- year dog feeding study with a NOAEL of 26 mg/kg/day and an uncertainty factor of 100.
Ref: Federal Register: December 12, 2001 (Volume 66, Number 239) [Notices] [Page 64257-64262]. Notice of Filing a Pesticide Petition to Establish a Tolerance fora Certain Pesticide Chemical in or on Food. http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Dec12.2001.htm

Body Weight Decrease (click on for all fluorinated pesticides)

-- In a developmental toxicity study, technical diflufenzopyr was administered by gavage to female Sprague Dawley rats at dose levels of 0, 100, 300, or 1000 mg/kg/day from days 6 through 15 of gestation. The maternal NOAEL is 300 mg/kg/day and the maternal LOAEL is 1000 mg/kg/day based on decreases in food consumption and weight gain. Developmental effects, characterized as significantly lower fetal body weights in males and skeletal variations, exhibited as incompletely ossified and unossified sternal centra and reduced fetal ossification sites for caudal vertebrae, were observed at 1000 mg/kg/day. The developmental LOAEL is 1000 mg/kg/day, based on decreased fetal body weights and skeletal variations. The developmental NOAEL is 300 mg/kg/day.
Ref: US EPA Fact Sheet. Reason for Issuance: Conditional Registration Date Issued: January 28, 1999.

http://www.epa.gov/opprd001/factsheets/diflufenzopr.pdf

52843-022; 173139; "SAN 835 H Technical Two Generation Reproduction Study in Rats" (Eschbach, B., Sandoz Agro Ltd., Department of Toxicology/B.881, CH-4002 Basel/Switzerland, Study No. 550R, 11/6/96). Twenty six Wistar rats per sex per dose level were administered SAN 835 H Technical (Lot No. 5904-4, 98.1% pure) in their feed at 0, 500, 2000 and 8000 ppm for 32 weeks. These animals, called the F0 generation, were mated twice during this time (first mating after 70 days of test article consumption), producing F1A and F1B litters. Twenty six weaned F1A animals per sex per dose level were selected and continued on feed containing the test article. After 84 days on the test diet they were mated and allowed to produce litters called F2A. Parents and nonselected pups were sacrificed on day 21 post-partum and subjected to necropsy. Control and high dose parents (F0 and F1) were processed for histopathology. Mean bodyweights of high dose parents were significantly lower than controls (p<0.05, P<0.01) throughout, including premating, gestation and lactation periods. In addition, F0 parental males fed 2000 ppm had a significantly lower bodyweight change (p<0.05) relative to controls over weeks 0-32. Food consumption was significantly increased (p<0.05, p<0.01) relative to controls in males during premating and in females during premating and gestation, at 2000 and 8000 ppm. Delivery and litter data from F1A dams (F2A pups) show increased incidence of the following: stillborn 5/3/5/17*, pre-perinatal loss 31/35/36/65**, pup loss during lactation days 1-4 6/7/4/28**, and pup loss during lactation days 1-21 8/17/10/34** (all for 0/500/2000/5000 ppm, *p<0.05, **p<0.01). However, the total number of liveborn pups was not decreased significantly at 8000 ppm. Mean pup bodyweights at day 21 of lactation were significantly lower than controls for high dose F1A pups only (40.9/42.8/39.6/35.5** grams, **p<0.01). Gross necropsy of male parents revealed a consistent increase in mean seminal vesicle weight in both 8000 ppm F0 males (relative to bodyweight and relative to brain weight, p<0.05) and 2000 and 8000 ppm F1 males (absolute, relative to bodyweight, and relative to brain weight, p<0.05). There were no microscopic correlates in the seminal vesicles. There was also no test article induction of any non-neoplastic or neoplastic microscopic lesions in parental animals. Gross necropsy of high dose pups detected an increased incidence (p<0.01) of runts (undersized animals) in F1A and F1B litters, increased (p<0.01) autolysis in F2A litters, and an increased incidence (p<0.01) of ̉no milk in stomachÓ in F2A litters. A few pup organ weights in the high dose group were significantly lower than controls: the thymus in F1B males (both absolute and relative to bodyweight, p<0.05) and F2A females (relative to bodyweight, p<0.05); the kidneys in F1B females (both absolute and relative to bodyweight, p<0.05) and F2A females (relative to bodyweight, p<0.05). No adverse effects indicated. Parental NOEL (M): 500 ppm (based on a lower mean bodyweight gain during weeks 0-32 in F0 males fed 2000 ppm); (F): 2000 ppm (based on lower mean bodyweights in females fed 8000 ppm). Reproductive NOEL (F): 2000 ppm (based on an increased incidence of stillborn pups and pre-perinatal loss in F1A dams fed 8000 ppm). Developmental NOEL (M/F): 2000 ppm (based on decreased pup survival [F2A], decreased mean pup bodyweights on day 21 [F1A], increased incidence of runts [F1A and F1B], increased autolysis [F2A] and increased incidence of ̉no milk in stomachÓ [F2A], decreased thymus weight [F1B males and F2A females] and decreased kidney weight [F1B females and F2A females], all in pups from dams fed 8000 ppm). Study acceptable (Vidair 4/18/00).

**017, 059, 060, 061, 062, 063; 173132, 175276, 175277, 175279, 175280, 175281; "SAN 835 H Neurotoxicity to Rats by Dietary Administration for 13 Weeks" (Hughes, E.W., Huntingdon Life Sciences Ltd., Huntingdon, Cambridgeshire, England, Project Identity SNC/187, BASF Reg. Doc. No. 97/5095, 11/5/96). 827. SAN 835 H (Batch No. 6500-19, purity=96.4%) was admixed to the diet at dose levels of 0 (untreated diet), 25, 75, or 1000 mg/kg/day and fed to 10 Crl: CD BR rats per sex per dose for 13 weeks. No mortalities occurred. A treatment-related decrease in mean body weight was observed in both sexes at 1000 mg/kg/day. Treatment-related decreases in mean activity and mean rearing in females during arena observations of FOB at 1000 mg/kg/day during the 4 th week of exposure but not during the 8 th and 13 th weeks. Motor activity assessments revealed no treatment-related effects. Microscopic examination of the nervous system revealed no treatment-related abnormalities. No adverse effects. NOEL (M/F)=75 mg/kg/day (based on decrease in body weight in both sexes and decreases in mean activity and rearing in females during FOB). Acceptable. (Corlett and Leung, 6/15/00)

TERATOLOGY, RABBIT **52843-020; 173136; "Developmental Toxicity (Embryo-Fetal Toxicity and Teratogenic Potential) Study of SAN 835 H Administered Orally via Stomach Tube to New Zealand White Rabbits" (Sharper, V., Argus Research Laboratories, Inc., Horsham, PA, Project ID No. 1819-008, 2/23/95). Twenty pregnant New Zealand White rabbits (strain Hra:[NZW]SPF) were administered a suspension of SAN 835 H (Lot No. 5904-4, 98.1% pure) via oral intubation at 0 (0.5% methylcellulose), 30, 100 and 300 mg/kg/day during days 6-19 of gestation, until sacrifice and Caesarean-section on day 29. Mortality was 1/2/1/4 for 0/30/100/300 mg/kg/day, with 0/0/0/3 deaths considered to have been caused by the test article. All 3 high dose deaths followed weight loss or failure to gain weight, and 2/3 animals had a trichobezoar in their stomach. The incidences of abortion were 0/0/1/5** (** p<0.01), with all high dose animals losing or failing to gain weight and 4/5 animals with a trichobezoar in their stomachs. Clinical signs included soft or liquid feces (number of rabbits exhibiting this sign: 0/1/4*/6**, * p<0.05, ** p<0.01), no feces (2/0/2/9**), and mucoid feces (0/0/0/3**). Mean maternal bodyweights were not significantly lower in treated animals relative to controls. However, high dose animals exhibited a lower mean bodyweight change (p<0.05) over days 12-15 and a higher mean change over days 24-29 (p<0.01), all relative to controls (the increase considered to have been a rebound effect, common to this type of study). Mean maternal food consumption (in g/kg/day) was lower (p<0.05) than controls in high dose animals for days 7-8. .. (Vidair 4/20/00).
Ref: July 13, 2000. Summary of Toxicology Data for Diflufenzopyr. CA EPA, Department of Pesticide Regulation, Medical Toxicology Branch.

http://www.fluorideaction.org/pesticides/diflufenzopyr.ca.epa.2000.pdf

Bone (click on for all fluorinated pesticides)

-- In a developmental toxicity study, technical diflufenzopyr was administered by gavage to female Sprague Dawley rats at dose levels of 0, 100, 300, or 1000 mg/kg/day from days 6 through 15 of gestation... Developmental effects, characterized as significantly lower fetal body weights in males( 5%) and skeletal variations, exhibited as incompletely ossified and unossified sternal centra and reduced fetal ossification sites for caudal vertebrae, were observed at 1000 mg/kg/day. The developmental LOAEL is 1000 mg/kg/day, based on decreased fetal body weights and skeletal variations. The developmental NOAEL is 300 mg/kg/day...
-- In a developmental toxicity study, technical diflufenzopyr was administered by gavage to female New Zealand White rabbits at dose levels of 0, 30, 100, or 300 mg/kg/day from days 6 through 19 of gestation. The maternal LOAEL is 100 mg/kg/day, based on minimal reductions in body weight gain with no reduction in food consumption and clinical signs of toxicity (abnormal feces). The maternal NOAEL is 30 mg/kg/day. Developmental effects, characterized as significant increases in the incidence of supernumerary thoracic rib pair ossification sites occurred at the 300 mg/kg/day dose. No treatment-related developmental effects were noted at the low and mid doses. The developmental LOAEL is 300 mg/kg/day based on increased skeletal variations (supernumerary rib ossification sites). The developmental NOAEL is 100 mg/kg/day.
Ref: US EPA Fact Sheet. Reason for Issuance: Conditional Registration Date Issued: January 28, 1999.
http://www.epa.gov/opprd001/factsheets/diflufenzopr.pdf

Dietary exposure. EPA has established the reference dose (RfD) for diflufenzopyr at 0.26 milligrams/kilogram/day (mg/kg/day). This RfD is based on bone marrow compensated hemolytic anemia observed in the 1- year dog feeding study with a NOAEL of 26 mg/kg/day and an uncertainty factor of 100.
Ref: Federal Register: December 12, 2001 (Volume 66, Number 239)] [Notices] [Page 64257-64262].
http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Dec12.2001.htm

Chronic Toxicity/Carcinogenicity. In a chronic toxicity study in dogs, diflufenzopyr was administered to beagle dogs in the diet at dose levels of 0, 750, 7500, or 15,000 ppm for 52 weeks. The LOAEL for this study is 7500 ppm (299 mg/kg/day for males and 301 mg/kg/day for females), based on erythroid hyperplasia in the bone marrow in bone sections, reticulocytosis, and increased hemosiderin deposits in the liver, kidneys, and spleen. The NOAEL is 750 ppm (26 mg/kg/day for males and 28 mg/kg/day for females).
Ref: US EPA. Diflufenzopyr Pesticide Fact Sheet. Conditional Registration. January 28, 1999.
http://www.fluorideaction.org/pesticides/diflufenzopr.epafacts.jan99.pdf

TERATOLOGY, RABBIT **52843-020; 173136; "Developmental Toxicity (Embryo-Fetal Toxicity and Teratogenic Potential) Study of SAN 835 H Administered Orally via Stomach Tube to New Zealand White Rabbits" (Sharper, V., Argus Research Laboratories, Inc., Horsham, PA, Project ID No. 1819-008, 2/23/95). Twenty pregnant New Zealand White rabbits (strain Hra:[NZW]SPF) were administered a suspension of SAN 835 H (Lot No. 5904-4, 98.1% pure) via oral intubation at 0 (0.5% methylcellulose), 30, 100 and 300 mg/kg/day during days 6-19 of gestation, until sacrifice... The incidences of supernumerary thoracic ribs (12.47/12.36/12.61/12.74**), thoracic vertebrae (12.54/12.42/12.67/12.79*) and lumbar vertebrae (6.45/6.56/6.32/6.20*, * p<0.05, ** p<0.01) were altered in high dose fetuses. However, the small magnitude of these changes, and the prior findings that these variations commonly occur at maternally toxic doses, cast doubt on their biological significance as developmental defects. No adverse effects indicated. Maternal NOEL = 30 mg/kg/day (based on abortions in does administered 100 and 300 mg/kg/day). Developmental NOEL = 300 mg/kg/day (based on similar incidences of malformations and variations in fetuses from control does and does administered 300 mg/kg/day). Study acceptable (Vidair 4/20/00).
Ref: July 13, 2000. Summary of Toxicology Data for Diflufenzopyr. CA EPA, Department of Pesticide Regulation, Medical Toxicology Branch.
http://www.fluorideaction.org/pesticides/diflufenzopyr.ca.epa.2000.pdf

Brain (click on for all fluorinated pesticides)

In an acute rat neurotoxicity study, diflufenzopyr was administered by gavage to Crl:CD BRR rats (10/ sex/group) at dose levels of 0, 125, 500 or 2,000 mg/kg... Lower mean brain weights in all female treatment groups.
Ref: Federal Register, January 28, 1999. Diflufenzopyr; Pesticide Tolerance. Final Rule.
http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Jan.1999.htm

Endocrine: Testicular (click on for all fluorinated pesticides)

Subschronic toxicity: Histopathological findings were an increased incidence of foamy macrophages in the lungs in the 10,000 and 20,000 ppm groups, both sexes, and testicular atrophy in the 20,000 ppm group. Following the 47-week recovery period, the only treatment-related effects which showed partial or no evidence of recovery were foamy macrophages in the lungs and testicular atrophy.
Ref: Federal Register: December 12, 2001 [Page 64257-64262]. Notice of Filing a Pesticide Petition to Establish a Tolerance fora Certain Pesticide Chemical in or on Food.
http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Dec12.2001.htm

015; 173127; "SAN 835 H: A 13-Week Dietary Toxicity Study in Rats with a 4-Week Recovery Period" (Simon, F.P.W. et al., Sandoz Agro Ltd., Department of Toxicology, Muttenz, Switzerland, Study No. 448-R, BASF Reg. Doc. No. 92/5244, 10/7/92). 821. SAN 835 H (Lot No. 5131-65C, purity=96%) was admixed to the diet at dose levels of 0 (untreated diet), 1000, 5000, 10000, or 20000 ppm (0, 65, 350, 720, or 1500 mg/kg/day, respectively, for males and 0, 70, 430, 890, or 1750 mg/kg/day, for females) and fed to 10 Wistar rats per sex per dose for 13 weeks (an additional 10 rats per sex per dose at the control and high dose levels were included to test recovery for 4 weeks following dosing). No mortalities occurred. A treatment-related decrease in mean body weight was observed in males at 10000 ppm and in both sexes at 20000 ppm persisting in recovery group males. A treatment-related increase in mean serum alanine aminotransferase level was observed in both sexes at 10000 and 20000 ppm but not in recovery group animals. Microscopic examination revealed treatment-related foam cells in the lungs in both sexes at 10000 and 20000 ppm and testicular atrophy at 20000 ppm with both conditions persisting in recovery group animals. Possible adverse effect: testicular atrophy at 20000 ppm (1500 mg/kg/day). NOEL (M)=350 mg/kg/day (5000 ppm) and (F)=430 mg/kg/day (5000 ppm) based on decreased body weight (in males), increased serum alanine aminotransferase levels (in both sexes), and foamy macrophages in the lungs (in both sexes). Acceptable. (Corlett and Leung, 5/11/00) (21-day dermal study)
Ref: Summary of Toxicology Data for Diflufenzopyr. CA EPA, Department of Pesticide Regulation, Medical Toxicology Branch. July 13, 2000.
http://www.fluorideaction.org/pesticides/diflufenzopyr.ca.epa.2000.pdf

In a 2-generation reproduction study, technical diflufenzopyr (98.1% a.i.) was administered continuously in the diet to 26 Wistar rats/sex/dose at dose levels of 0, 500, 2,000 or 8,000 ppm in the diet (0, 27.3-42.2, 113.1-175.9, or 466.2-742.0 mg/kg/day). The systemic LOAEL is 2,000 ppm (113.1-175.9 mg/kg/day) based on reduced body weight gain, increased food consumption, and increased seminal vesicle weights. The systemic NOAEL is 500 ppm (27.3-42.2 mg/kg/day). The reproductive LOAEL is 8,000 ppm (466.2-742.0 mg/kg/day) based on lower live birth and viability indices, total pre-perinatal loss, reduced body weights and body weight gain during lactation, a higher proportion of runts, and a higher percentage of offspring with no milk in the stomach. The reproductive NOAEL is 2,000 ppm (113.1-175.9 mg/kg/day).
Ref: Federal Register: January 28, 1999. Diflufenzopyr; Pesticide Tolerance. Final Rule.

http://www.fluorideaction.org/pesticides/diflufenzopyr.fr.jan.1999.htm

Endocrine: Thymus (click on for all fluorinated pesticides)

Toxicological Profile... A 90-day feeding study in the dog at approximate doses of 0, 0.25, 1, 5, 50, 150, or 400 mg/kg/day. Liver, kidney, stomach, and thymus were identified as target organs. The NOEL was 50 mg/kg/day. The maximum tolerated dose was exceeded at > 150 mg/kg/day.
Ref: Federal Register: November 21, 1997 [Page 62304-62308].
http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Nov21.1997.htm

Kidney (click on for all fluorinated pesticides)

Chronic toxicity. A 52-week feeding study in the dog at doses of 0, 1, 5, 40, or 80 mg/kg. Liver and kidney were identified as target organs and the NOEL was established at 5 mg/kg... A 90-day feeding study in the dog at approximate doses of 0, 0.25, 1, 5, 50, 150, or 400 mg/kg/day. Liver, kidney, stomach, and thymus were identified as target organs. The NOEL was 50 mg/kg/day. The maximum tolerated dose was exceeded at > 150 mg/kg/day...
Ref: Federal Register. November 21, 1997. [PF-778; FRL-5755-4]
http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Nov21.1997.htm

Lung (click on for all fluorinated pesticides)

Subschronic toxicity: Histopathological findings were an increased incidence of foamy macrophages in the lungs in the 10,000 and 20,000 ppm groups, both sexes, and testicular atrophy in the 20,000 ppm group. Following the 47-week recovery period, the only treatment-related effects which showed partial or no evidence of recovery were foamy macrophages in the lungs and testicular atrophy.
Ref: Federal Register: December 12, 2001 [Page 64257-64262]. Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on Food.

http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Dec12.2001.htm

Spleen (click on for all fluorinated pesticides)

Chronic toxicity--i. 1-Year non-rodent (dog). Beagle dogs were dosed with diflufenzopyr at 0, 750, 7,500 and 15,000 ppm in the diet for one year. The NOEL was determined to be 750 ppm (26 mg/kg/day) in males and (28 mg/kg/day) in females. The LOAEL was 7,500 ppm (299 mg/ kg/day) in males and (301 mg/kg/day) in females. This is based on an erythropoietic response in bone marrow and increased hemosiderin deposits in spleen, liver and kidneys.
Ref: Federal Register: November 21, 1997 (Volume 62, Number 225) [Notices] [Page 62304-62308]. Notice of Filing of Pesticide Petitions
http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Nov21.1997.htm

Environmental (click on for all fluorinated pesticides)

A metabolite of diflufenzopyr known as M9: 8-methylpyrido[2,3-d]pyridazine-2,5(1H, 6H)-dione
• Results of biotransformation studies using a loam soil under aerobic conditions indicate that diflufenzopyr will be non persistent, and transformation product M9 will be persistent (page 33)
• Results of biotransformation studies in a flooded sandy loam soil with pond water under anaerobic conditions indicate that diflufenzopyr is expected to be slightly persistent under anaerobic aquatic conditions. Of the two major transformation products that were formed, M1 was transient and M9 has potential for persistence in water and sediment under anaerobic conditions. (page 33)
• For biotic transformation in the terrestrial environment, diflufenzopyr was not persistent under aerobic soil conditions and transformation product M9 was persistent (page 37)
• For biotic transformation in the aquatic environment, diflufenzopyr was slightly persistent under aerobic aquatic conditions (McEwan and Stephenson 1979). Major transient transformation products M1 and M9 were detected at a maximum of 16% of the applied adioactivity, and were not expected to persist in the aquatic environment. Under anaerobic aquatic conditions, diflufenzopyr was slightly persistent (McEwan and Stephenson 1979). Of the two major transformation products that were formed, M1 was transient and M9 persisted in water. (page 38)
Ref: March 4, 2005 - DISTINCT. Proposed Regulatory Decision Document PRDD2005-01. Pest Management Regulatory Agency. Ottawa, Canada. The herbicide Distinct contains 20% diflufenzopyr (109293-97-2) and 50% dicamba

 

A February 14, 2005, check at the Code of Federal Regulations for Diflubenzopyr: this herbicide is permitted in or on 31 food commodities in the United States. The following list identifies these crops for which EPA has set pesticide tolerances. 

[Code of Federal Regulations]
[Title 40, Volume 22]
[Revised as of July 1, 2004]
From the U.S. Government Printing Office via GPO Access
[CITE: 40CFR180.549]

[Page 500]

TITLE 40--PROTECTION OF ENVIRONMENT

CHAPTER I--ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)

PART 180_TOLERANCES AND EXEMPTIONS FROM TOLERANCES FOR PESTICIDE CHEMICALS
IN FOOD--Table of Contents

Subpart C_Specific Tolerances

Sec. 180.549 Diflufenzopyr; tolerances for residues.
(a) General. Tolerances are established for combined residues of
diflufenzopyr
, 2-(1-[([3,5-difluorophenylamino]
carbonyl)hydrazono]ethyl)-3-pyridinecarboxylic acid, and its metabolites
convertible to 8-methylpyrido[2,3-d]pyridazin-5(6H)-one
, expressed as
diflufenzopyr, in or on the following raw agricultural commodities:

Commodity

As of September 25, 2003

PPM

As of February 14, 2005

PPM

US Code of Federal Regulations

CFR

Corn, field, forage 0.05 0.05 180.549
Corn, field, grain 0.05 0.05 180.549
Corn, field, stover. 0.05 0.05 180.549
Corn, pop, grain 0.05 0.05 180.549
Corn, pop, stover 0.05 0.05 180.549
Corn, sweet, forage 0.05 0.05 180.549
Corn, sweet, kernel plus cob with husks removed 0.05 0.05 180.549
Corn, sweet, stover 0.05 0.05 180.549
Grass, forage 22 22.0 180.549
Grass, hay 7.0 7.0 180.549
(2) Time-limited tolerances are established for combined residues of
diflufenzopyr, 2-(1-[([3,5-difluorophenylamino]
carbonyl)hydrazono]ethyl)-3- pyridinecarboxylic acid, its metabolites
convertible to 8-methylpyrido[2,3-d]pyridazin- 5(6H)-one, and free and
acid-released 8-hydroxymethylpyrido[2,3-d]pyridazine-2,5(1H,6H)-dione,
expressed as diflufenzopyr, in or on the following raw agricultural commodities:
Commodity

As of September 25, 2003

PPM

As of February 14, 2005

PPM

Expiration/ Revocation Date

Cattle, fat 0.30 0.30 7/31/05 
Cattle, kidney 4.0 4.0 7/31/05 
Cattle, meat 0.60 0.60 7/31/05 
Cattle, meat byproducts, except kidney 0.50 0.50 7/31/05 
Goat, fat 0.30 0.30 7/31/05 
Goat, kidney 4.0 4.0 7/31/05 
Goat, meat 0.60 0.60 7/31/05
Goat, meat byproducts, except kidney 0.50 0.50 7/31/05 
Hog, fat 0.30 0.30 7/31/05 
Hog, kidney 4.0 4.0 7/31/05 
Hog, meat 0.60 0.60 7/31/05 
Hog, meat byproducts, except kidney 0.50 0.50 7/31/05 
Horse, fat 0.30 0.30 7/31/05
Horse, kidney 4.0 4.0 7/31/05 
Horse, meat 0.60 0.60 7/31/05 
Horse, meat byproducts, except kidney 0.50 0.50 7/31/05 
Milk 3.0 3.0 7/31/05 
Sheep, fat 0.30 0.30 7/31/05 
Sheep, kidney 4.0 4.0 7/31/05 
Sheep, meat 0.60 0.60 7/31/05 
Sheep, meat byproducts, except kidney 0.50 0.50 7/31/05 
(b) Section 18 emergency exemptions. [Reserved]
(c) Tolerances with regional registrations. [Reserved]
(d) Indirect or inadvertent residues. [Reserved]
 
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