Return to Diflufenzopyr
Index Page
Activity: Herbicide
(urea)
Structure:
Adverse Effects:
Anemia
Body Weight Decrease
Bone
Brain
Endocrine: Testicular
Endocrine: Thymus
Kidney
Lung
Spleen
Environmental
As of
February 14, 2005, this herbicide is permitted in
or on 31 food commodities
in the United States - see list at bottom of page.
|
Anemia (click
on for all fluorinated pesticides)
Dietary exposure. EPA
has established the reference dose (RfD) for diflufenzopyr at
0.26 milligrams/kilogram/day (mg/kg/day). This RfD is based on
bone marrow compensated hemolytic anemia
observed in the 1- year dog feeding study with a NOAEL of 26 mg/kg/day
and an uncertainty factor of 100.
Ref: Federal Register: December 12, 2001
(Volume 66, Number 239) [Notices] [Page 64257-64262]. Notice of
Filing a Pesticide Petition to Establish a Tolerance fora Certain
Pesticide Chemical in or on Food. http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Dec12.2001.htm
Body
Weight Decrease (click
on for all fluorinated pesticides)
-- In a developmental
toxicity study, technical diflufenzopyr was administered by gavage
to female Sprague Dawley rats at
dose levels of 0, 100, 300, or 1000 mg/kg/day from days 6 through
15 of gestation. The maternal NOAEL is 300 mg/kg/day and the maternal
LOAEL is 1000 mg/kg/day based on decreases
in food consumption and weight gain. Developmental effects,
characterized as significantly lower fetal
body weights in males and skeletal
variations, exhibited as incompletely ossified and unossified
sternal centra and reduced fetal ossification sites for caudal
vertebrae, were observed at 1000 mg/kg/day. The developmental
LOAEL is 1000 mg/kg/day, based on decreased
fetal body weights and skeletal variations.
The developmental NOAEL is 300 mg/kg/day.
Ref: US EPA Fact Sheet. Reason for Issuance:
Conditional Registration Date Issued: January 28, 1999.
http://www.epa.gov/opprd001/factsheets/diflufenzopr.pdf
52843-022; 173139;
"SAN 835 H Technical Two Generation Reproduction Study in
Rats" (Eschbach, B., Sandoz
Agro Ltd., Department of Toxicology/B.881, CH-4002 Basel/Switzerland,
Study No. 550R, 11/6/96). Twenty six Wistar rats per sex per dose
level were administered SAN 835 H Technical (Lot No. 5904-4, 98.1%
pure) in their feed at 0, 500, 2000 and 8000 ppm for 32 weeks.
These animals, called the F0 generation, were mated twice during
this time (first mating after 70 days of test article consumption),
producing F1A and F1B litters. Twenty six weaned F1A animals per
sex per dose level were selected and continued on feed containing
the test article. After 84 days on the test diet they were mated
and allowed to produce litters called F2A. Parents and nonselected
pups were sacrificed on day 21 post-partum and subjected to necropsy.
Control and high dose parents (F0 and F1) were processed for histopathology.
Mean bodyweights of high dose parents were significantly lower
than controls (p<0.05, P<0.01) throughout, including premating,
gestation and lactation periods. In addition, F0
parental males fed 2000 ppm had a significantly lower bodyweight
change (p<0.05) relative to controls over weeks 0-32. Food
consumption was significantly increased (p<0.05, p<0.01) relative
to controls in males during premating and in females during premating
and gestation, at 2000 and 8000 ppm. Delivery and litter data
from F1A dams (F2A pups) show increased incidence of the following:
stillborn 5/3/5/17*, pre-perinatal loss 31/35/36/65**, pup loss
during lactation days 1-4 6/7/4/28**, and pup loss during lactation
days 1-21 8/17/10/34** (all for 0/500/2000/5000 ppm, *p<0.05,
**p<0.01). However, the total number of liveborn pups was not
decreased significantly at 8000 ppm. Mean
pup bodyweights at day 21 of lactation were significantly lower
than controls for high dose F1A pups only (40.9/42.8/39.6/35.5**
grams, **p<0.01). Gross necropsy of male parents revealed a consistent
increase in mean seminal vesicle weight in both 8000 ppm F0 males
(relative to bodyweight and relative to brain weight, p<0.05)
and 2000 and 8000 ppm F1 males (absolute, relative to bodyweight,
and relative to brain weight, p<0.05). There were no microscopic
correlates in the seminal vesicles. There was also no test article
induction of any non-neoplastic or neoplastic microscopic lesions
in parental animals. Gross necropsy of high dose pups detected
an increased incidence (p<0.01) of runts
(undersized animals) in F1A and F1B litters, increased
(p<0.01) autolysis in F2A litters, and an increased incidence
(p<0.01) of ̉no milk in stomachÓ in F2A litters. A
few pup organ weights in the high dose group were significantly
lower than controls: the thymus in F1B males (both absolute
and relative to bodyweight, p<0.05) and F2A females (relative
to bodyweight, p<0.05); the kidneys in F1B females (both absolute
and relative to bodyweight, p<0.05) and F2A females (relative
to bodyweight, p<0.05). No adverse effects indicated. Parental
NOEL (M): 500 ppm (based on a lower mean bodyweight gain
during weeks 0-32 in F0 males fed 2000 ppm); (F): 2000 ppm (based
on lower mean bodyweights in females
fed 8000 ppm). Reproductive NOEL (F): 2000 ppm (based on an increased
incidence of stillborn pups and pre-perinatal loss in F1A dams
fed 8000 ppm). Developmental NOEL (M/F): 2000 ppm (based on decreased
pup survival [F2A], decreased mean pup bodyweights
on day 21 [F1A], increased incidence of runts [F1A and F1B], increased
autolysis [F2A] and increased incidence of ̉no milk in stomachÓ
[F2A], decreased thymus weight [F1B males and F2A females] and
decreased kidney weight [F1B females and F2A females], all in
pups from dams fed 8000 ppm). Study acceptable (Vidair 4/18/00).
**017, 059, 060, 061,
062, 063; 173132, 175276, 175277, 175279, 175280, 175281; "SAN
835 H Neurotoxicity to Rats by Dietary
Administration for 13 Weeks" (Hughes, E.W., Huntingdon Life
Sciences Ltd., Huntingdon, Cambridgeshire, England, Project Identity
SNC/187, BASF Reg. Doc. No. 97/5095, 11/5/96). 827. SAN 835 H
(Batch No. 6500-19, purity=96.4%) was admixed to the diet at dose
levels of 0 (untreated diet), 25, 75, or 1000 mg/kg/day and fed
to 10 Crl: CD BR rats per sex per dose for 13 weeks. No mortalities
occurred. A treatment-related decrease in mean
body weight was observed in both sexes at 1000 mg/kg/day.
Treatment-related decreases in mean activity and mean rearing
in females during arena observations of FOB at 1000 mg/kg/day
during the 4 th week of exposure but not during the 8 th and 13
th weeks. Motor activity assessments revealed no treatment-related
effects. Microscopic examination of the nervous system revealed
no treatment-related abnormalities. No adverse effects.
NOEL (M/F)=75 mg/kg/day (based on decrease in body weight in both
sexes and decreases in mean activity and rearing in females
during FOB). Acceptable. (Corlett and Leung, 6/15/00)
TERATOLOGY,
RABBIT **52843-020; 173136; "Developmental Toxicity
(Embryo-Fetal Toxicity and Teratogenic Potential) Study of SAN
835 H Administered Orally via Stomach Tube to New Zealand White
Rabbits" (Sharper, V., Argus Research Laboratories, Inc.,
Horsham, PA, Project ID No. 1819-008, 2/23/95). Twenty pregnant
New Zealand White rabbits (strain Hra:[NZW]SPF) were administered
a suspension of SAN 835 H (Lot No. 5904-4, 98.1% pure) via oral
intubation at 0 (0.5% methylcellulose),
30, 100 and 300 mg/kg/day during days 6-19 of gestation,
until sacrifice and Caesarean-section on day 29. Mortality was
1/2/1/4 for 0/30/100/300 mg/kg/day, with 0/0/0/3 deaths considered
to have been caused by the test article. All
3 high dose deaths followed weight loss or failure to gain weight,
and 2/3 animals had a trichobezoar in their stomach. The incidences
of abortion were 0/0/1/5** (** p<0.01), with all
high dose animals losing or failing to gain weight and
4/5 animals with a trichobezoar in their stomachs. Clinical signs
included soft or liquid feces (number of rabbits exhibiting this
sign: 0/1/4*/6**, * p<0.05, ** p<0.01), no feces (2/0/2/9**),
and mucoid feces (0/0/0/3**). Mean maternal bodyweights were not
significantly lower in treated animals relative to controls. However,
high dose animals exhibited a lower mean
bodyweight change (p<0.05) over days 12-15 and a higher
mean change over days 24-29 (p<0.01), all relative to controls
(the increase considered to have been a rebound effect, common
to this type of study). Mean maternal food consumption (in g/kg/day)
was lower (p<0.05) than controls in high dose animals for days
7-8. .. (Vidair 4/20/00).
Ref: July 13, 2000. Summary of Toxicology
Data for Diflufenzopyr. CA EPA, Department of Pesticide Regulation,
Medical Toxicology Branch.
http://www.fluorideaction.org/pesticides/diflufenzopyr.ca.epa.2000.pdf
Bone
(click on for all fluorinated
pesticides)
-- In a developmental
toxicity study, technical diflufenzopyr was administered by gavage
to female Sprague Dawley rats at
dose levels of 0, 100, 300, or 1000 mg/kg/day from days 6 through
15 of gestation... Developmental effects, characterized as
significantly
lower fetal body weights in males( 5%) and skeletal
variations, exhibited as incompletely ossified
and unossified sternal
centra and reduced fetal ossification sites for caudal vertebrae,
were observed at 1000 mg/kg/day. The developmental LOAEL is 1000
mg/kg/day, based on decreased fetal body weights and skeletal
variations. The developmental NOAEL is 300 mg/kg/day...
-- In a developmental toxicity study, technical diflufenzopyr
was administered by gavage to female New Zealand White rabbits
at dose levels of 0, 30, 100, or 300 mg/kg/day from days 6 through
19 of gestation. The maternal LOAEL is 100 mg/kg/day, based on
minimal reductions in body weight gain with no reduction in food
consumption and clinical signs of toxicity (abnormal feces). The
maternal NOAEL is 30 mg/kg/day. Developmental effects, characterized
as significant increases in the incidence
of supernumerary thoracic rib pair ossification sites occurred
at the 300 mg/kg/day dose. No treatment-related developmental
effects were noted at the low and mid doses. The developmental
LOAEL is 300 mg/kg/day based on increased
skeletal variations (supernumerary rib ossification sites).
The developmental NOAEL is 100 mg/kg/day.
Ref: US EPA Fact Sheet. Reason for Issuance:
Conditional Registration Date Issued: January 28, 1999.
http://www.epa.gov/opprd001/factsheets/diflufenzopr.pdf
Dietary exposure. EPA
has established the reference dose (RfD) for diflufenzopyr at
0.26 milligrams/kilogram/day (mg/kg/day). This RfD is based on
bone marrow
compensated hemolytic anemia observed in the 1- year dog feeding
study with a NOAEL of 26 mg/kg/day and an uncertainty factor of
100.
Ref: Federal Register: December 12, 2001
(Volume 66, Number 239)] [Notices] [Page 64257-64262].
http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Dec12.2001.htm
Chronic Toxicity/Carcinogenicity.
In a chronic toxicity study in dogs, diflufenzopyr was administered
to beagle dogs in the diet at dose levels of 0, 750, 7500, or
15,000 ppm for 52 weeks. The LOAEL for this study is 7500 ppm
(299 mg/kg/day for males and 301 mg/kg/day for females), based
on erythroid hyperplasia in the bone marrow
in bone sections, reticulocytosis, and increased hemosiderin
deposits in the liver, kidneys, and spleen. The NOAEL is 750 ppm
(26 mg/kg/day for males and 28 mg/kg/day for females).
Ref: US EPA. Diflufenzopyr Pesticide Fact
Sheet. Conditional Registration. January 28, 1999.
http://www.fluorideaction.org/pesticides/diflufenzopr.epafacts.jan99.pdf
TERATOLOGY, RABBIT
**52843-020; 173136; "Developmental Toxicity (Embryo-Fetal
Toxicity and Teratogenic Potential) Study of SAN 835 H Administered
Orally via Stomach Tube to New Zealand White Rabbits" (Sharper,
V., Argus Research Laboratories, Inc., Horsham, PA, Project ID
No. 1819-008, 2/23/95). Twenty pregnant New Zealand White rabbits
(strain Hra:[NZW]SPF) were administered a suspension of SAN 835
H (Lot No. 5904-4, 98.1% pure) via oral intubation at 0 (0.5%
methylcellulose), 30, 100 and 300 mg/kg/day
during days 6-19 of gestation, until sacrifice... The
incidences of supernumerary thoracic ribs (12.47/12.36/12.61/12.74**),
thoracic vertebrae (12.54/12.42/12.67/12.79*) and lumbar vertebrae
(6.45/6.56/6.32/6.20*, * p<0.05, ** p<0.01) were altered in high
dose fetuses. However, the small magnitude of these changes,
and the prior findings that these variations commonly occur at
maternally toxic doses, cast doubt on their biological significance
as developmental defects. No adverse effects indicated. Maternal
NOEL = 30 mg/kg/day (based on abortions in does administered 100
and 300 mg/kg/day). Developmental NOEL = 300 mg/kg/day (based
on similar incidences of malformations and
variations in fetuses from control does and does administered
300 mg/kg/day). Study acceptable (Vidair 4/20/00).
Ref: July 13, 2000. Summary of Toxicology
Data for Diflufenzopyr. CA EPA, Department of Pesticide Regulation,
Medical Toxicology Branch.
http://www.fluorideaction.org/pesticides/diflufenzopyr.ca.epa.2000.pdf
Brain
(click
on for all fluorinated pesticides)
In an acute rat neurotoxicity study, diflufenzopyr was administered
by gavage to Crl:CD BRR rats (10/ sex/group) at dose levels of
0, 125, 500 or 2,000 mg/kg... Lower mean
brain weights in all female treatment groups.
Ref: Federal Register, January 28, 1999.
Diflufenzopyr; Pesticide Tolerance. Final Rule.
http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Jan.1999.htm
Endocrine:
Testicular (click
on for all fluorinated pesticides)
Subschronic toxicity:
Histopathological findings were an increased incidence of foamy
macrophages in the lungs in the 10,000 and 20,000 ppm groups,
both sexes, and testicular atrophy
in the 20,000 ppm group. Following the 47-week recovery period,
the only treatment-related effects which showed partial or no
evidence of recovery were foamy macrophages in the lungs and
testicular atrophy.
Ref: Federal Register: December 12, 2001
[Page 64257-64262]. Notice of Filing a Pesticide Petition to Establish
a Tolerance fora Certain Pesticide Chemical in or on Food.
http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Dec12.2001.htm
015; 173127; "SAN
835 H: A 13-Week Dietary Toxicity Study in Rats with a 4-Week
Recovery Period" (Simon, F.P.W. et al., Sandoz Agro Ltd.,
Department of Toxicology, Muttenz, Switzerland, Study No. 448-R,
BASF Reg. Doc. No. 92/5244, 10/7/92). 821. SAN 835 H (Lot No.
5131-65C, purity=96%) was admixed to the diet at dose levels of
0 (untreated diet), 1000, 5000, 10000, or 20000 ppm (0, 65, 350,
720, or 1500 mg/kg/day, respectively, for males and 0, 70, 430,
890, or 1750 mg/kg/day, for females) and fed to 10 Wistar rats
per sex per dose for 13 weeks (an additional 10 rats per sex per
dose at the control and high dose levels were included to test
recovery for 4 weeks following dosing). No mortalities occurred.
A treatment-related decrease in mean body weight was observed
in males at 10000 ppm and in both sexes at 20000 ppm persisting
in recovery group males. A treatment-related increase in mean
serum alanine aminotransferase level was observed in both sexes
at 10000 and 20000 ppm but not in recovery group animals. Microscopic
examination revealed treatment-related foam cells in the lungs
in both sexes at 10000 and 20000 ppm and testicular
atrophy at 20000 ppm with both conditions persisting in recovery
group animals. Possible adverse effect: testicular atrophy at
20000 ppm (1500 mg/kg/day). NOEL (M)=350 mg/kg/day (5000
ppm) and (F)=430 mg/kg/day (5000 ppm) based on decreased body
weight (in males), increased serum alanine aminotransferase levels
(in both sexes), and foamy macrophages in the lungs (in both sexes).
Acceptable. (Corlett and Leung, 5/11/00) (21-day dermal study)
Ref: Summary of Toxicology Data for Diflufenzopyr.
CA EPA, Department of Pesticide Regulation, Medical Toxicology
Branch. July 13, 2000.
http://www.fluorideaction.org/pesticides/diflufenzopyr.ca.epa.2000.pdf
In
a 2-generation reproduction study, technical diflufenzopyr (98.1%
a.i.) was administered continuously in the diet to 26 Wistar rats/sex/dose
at dose levels of 0, 500, 2,000 or 8,000 ppm in the diet (0, 27.3-42.2,
113.1-175.9, or 466.2-742.0 mg/kg/day). The systemic LOAEL is
2,000 ppm (113.1-175.9 mg/kg/day) based on reduced body weight
gain, increased food consumption, and increased seminal
vesicle weights. The systemic NOAEL is 500 ppm (27.3-42.2
mg/kg/day). The reproductive LOAEL is 8,000 ppm (466.2-742.0 mg/kg/day)
based on lower live birth and viability indices, total pre-perinatal
loss, reduced body weights and body weight gain during lactation,
a higher proportion of runts, and a higher percentage of offspring
with no milk in the stomach. The reproductive NOAEL is 2,000 ppm
(113.1-175.9 mg/kg/day).
Ref: Federal Register: January 28, 1999.
Diflufenzopyr; Pesticide Tolerance. Final Rule.
http://www.fluorideaction.org/pesticides/diflufenzopyr.fr.jan.1999.htm
Endocrine:
Thymus
(click
on for all fluorinated pesticides)
Toxicological Profile...
A 90-day feeding study in the dog at approximate doses of 0, 0.25,
1, 5, 50, 150, or 400 mg/kg/day. Liver, kidney, stomach, and
thymus were identified as target
organs. The NOEL was 50 mg/kg/day. The maximum tolerated
dose was exceeded at > 150 mg/kg/day.
Ref: Federal Register: November 21, 1997
[Page 62304-62308].
http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Nov21.1997.htm
Kidney
(click
on for all fluorinated pesticides)
Chronic toxicity. A
52-week feeding study in the dog at doses of 0, 1, 5, 40, or 80
mg/kg. Liver and kidney were identified
as target organs and the NOEL was established at 5 mg/kg...
A 90-day feeding study in the dog at approximate doses of 0, 0.25,
1, 5, 50, 150, or 400 mg/kg/day. Liver,
kidney, stomach, and thymus were identified as target organs.
The NOEL was 50 mg/kg/day. The maximum tolerated dose was
exceeded at > 150 mg/kg/day...
Ref: Federal Register. November 21, 1997.
[PF-778; FRL-5755-4]
http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Nov21.1997.htm
Lung
(click
on for all fluorinated pesticides)
Subschronic toxicity:
Histopathological findings were an increased incidence of foamy
macrophages in the lungs in the 10,000 and 20,000 ppm
groups, both sexes, and testicular
atrophy
in the 20,000 ppm group. Following the 47-week recovery period,
the only treatment-related effects which showed partial or no
evidence of recovery were foamy macrophages
in the lungs and testicular atrophy.
Ref: Federal Register: December 12, 2001
[Page 64257-64262]. Notice of Filing a Pesticide Petition to Establish
a Tolerance for a Certain Pesticide Chemical in or on Food.
http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Dec12.2001.htm
Spleen
(click
on for all fluorinated pesticides)
Chronic toxicity--i.
1-Year non-rodent (dog). Beagle dogs were dosed with diflufenzopyr
at 0, 750, 7,500 and 15,000 ppm in the diet for one year. The
NOEL was determined to be 750 ppm (26 mg/kg/day) in males and
(28 mg/kg/day) in females. The LOAEL was 7,500 ppm (299 mg/ kg/day)
in males and (301 mg/kg/day) in females. This is based on an erythropoietic
response in bone marrow and increased hemosiderin
deposits in spleen, liver and kidneys.
Ref: Federal Register: November 21, 1997
(Volume 62, Number 225) [Notices] [Page 62304-62308]. Notice of
Filing of Pesticide Petitions
http://www.fluoridealert.org/pesticides/Diflufenzopyr.FR.Nov21.1997.htm
Environmental
(click
on for all fluorinated pesticides)
A metabolite
of diflufenzopyr known as M9:
8-methylpyrido[2,3-d]pyridazine-2,5(1H, 6H)-dione
• Results of biotransformation studies using a loam
soil under aerobic conditions indicate that diflufenzopyr
will be non persistent, and transformation product M9
will be persistent (page 33)
• Results of biotransformation studies in a
flooded sandy loam soil with pond water under anaerobic
conditions indicate that diflufenzopyr is expected
to be slightly persistent under anaerobic aquatic conditions.
Of the two major transformation products that were formed,
M1 was transient and M9 has potential
for persistence in water and sediment under anaerobic conditions.
(page 33)
• For biotic transformation
in the terrestrial environment, diflufenzopyr was
not persistent under aerobic soil
conditions and transformation product M9
was persistent (page 37)
• For biotic transformation
in the aquatic environment, diflufenzopyr was slightly
persistent under aerobic aquatic conditions
(McEwan and Stephenson 1979). Major transient transformation
products M1 and M9 were detected at a maximum of 16% of
the applied adioactivity, and were not expected to persist
in the aquatic environment. Under anaerobic aquatic conditions,
diflufenzopyr was slightly persistent (McEwan and Stephenson
1979). Of the two major transformation products that were
formed, M1 was transient and M9 persisted
in water. (page 38)
Ref: March 4, 2005 - DISTINCT.
Proposed Regulatory Decision Document PRDD2005-01. Pest
Management Regulatory Agency. Ottawa, Canada. The herbicide
Distinct contains 20% diflufenzopyr (109293-97-2) and 50%
dicamba
|
A
February 14, 2005, check at the Code
of Federal Regulations for Diflubenzopyr: this herbicide is
permitted in or on 31
food commodities in the
United States. The
following list identifies these crops for which EPA has set
pesticide tolerances.
|
[Code
of Federal Regulations]
[Title 40, Volume 22]
[Revised as of July 1, 2004]
From the U.S. Government Printing Office via GPO Access
[CITE: 40CFR180.549]
[Page
500]
TITLE 40--PROTECTION OF ENVIRONMENT
CHAPTER I--ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)
PART 180_TOLERANCES AND EXEMPTIONS FROM TOLERANCES FOR PESTICIDE
CHEMICALS
IN FOOD--Table of Contents
Subpart C_Specific Tolerances
Sec. 180.549 Diflufenzopyr; tolerances for residues.
(a) General. Tolerances are established for
combined residues of
diflufenzopyr, 2-(1-[([3,5-difluorophenylamino]
carbonyl)hydrazono]ethyl)-3-pyridinecarboxylic acid, and
its metabolites
convertible to 8-methylpyrido[2,3-d]pyridazin-5(6H)-one,
expressed as
diflufenzopyr, in or on the following raw agricultural commodities:
|
Commodity |
As
of September 25, 2003
PPM |
As
of February 14, 2005
PPM |
US
Code of Federal Regulations
CFR |
Corn,
field, forage |
0.05 |
0.05 |
180.549
|
Corn,
field, grain |
0.05 |
0.05 |
180.549
|
Corn,
field, stover. |
0.05 |
0.05 |
180.549
|
Corn,
pop, grain |
0.05 |
0.05 |
180.549
|
Corn,
pop, stover |
0.05 |
0.05 |
180.549
|
Corn,
sweet, forage |
0.05 |
0.05 |
180.549
|
Corn,
sweet, kernel plus cob with husks removed |
0.05 |
0.05 |
180.549
|
Corn,
sweet, stover |
0.05 |
0.05 |
180.549
|
Grass,
forage |
22 |
22.0 |
180.549
|
Grass,
hay |
7.0 |
7.0 |
180.549
|
(2)
Time-limited tolerances are established
for combined residues of
diflufenzopyr, 2-(1-[([3,5-difluorophenylamino]
carbonyl)hydrazono]ethyl)-3- pyridinecarboxylic acid, its
metabolites
convertible to 8-methylpyrido[2,3-d]pyridazin- 5(6H)-one,
and free and
acid-released 8-hydroxymethylpyrido[2,3-d]pyridazine-2,5(1H,6H)-dione,
expressed as diflufenzopyr, in or on the following raw agricultural
commodities: |
Commodity |
As
of September 25, 2003
PPM |
As
of February 14, 2005
PPM |
Expiration/ Revocation Date |
Cattle,
fat |
0.30 |
0.30
|
7/31/05
|
Cattle,
kidney |
4.0 |
4.0
|
7/31/05
|
Cattle,
meat |
0.60 |
0.60
|
7/31/05
|
Cattle,
meat byproducts, except kidney |
0.50 |
0.50 |
7/31/05
|
Goat,
fat |
0.30 |
0.30 |
7/31/05
|
Goat,
kidney |
4.0 |
4.0 |
7/31/05
|
Goat,
meat |
0.60 |
0.60 |
7/31/05 |
Goat,
meat byproducts, except kidney |
0.50 |
0.50 |
7/31/05
|
Hog,
fat |
0.30 |
0.30
|
7/31/05
|
Hog,
kidney |
4.0 |
4.0 |
7/31/05
|
Hog,
meat |
0.60 |
0.60 |
7/31/05
|
Hog,
meat byproducts, except kidney |
0.50 |
0.50
|
7/31/05
|
Horse,
fat |
0.30 |
0.30 |
7/31/05 |
Horse,
kidney |
4.0 |
4.0 |
7/31/05
|
Horse,
meat |
0.60 |
0.60
|
7/31/05
|
Horse,
meat byproducts, except kidney |
0.50 |
0.50 |
7/31/05
|
Milk |
3.0 |
3.0
|
7/31/05
|
Sheep,
fat |
0.30 |
0.30 |
7/31/05
|
Sheep,
kidney |
4.0 |
4.0
|
7/31/05
|
Sheep,
meat |
0.60 |
0.60 |
7/31/05
|
Sheep,
meat byproducts, except kidney |
0.50 |
0.50 |
7/31/05
|
(b)
Section 18 emergency exemptions. [Reserved]
(c) Tolerances with regional registrations. [Reserved]
(d) Indirect or inadvertent residues. [Reserved] |
|