Adverse Effects
Diclosulam
CAS No. 145701-21-9

 
 

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ACTIVITY: Herbicide (triazolopyrimidine)
Structure:

Adverse Effects:
Body Weight Decrease
Kidney
Liver

As of February 17, 2005, this herbicide is permitted in or on 2 food commodities in the United States - see list at bottom of page.


Body Weight Decrease (click on for all fluorinated pesticides)

-- Chronic toxicity. EPA has established a chronic RfD of 0.05 mg/ kg/day NOAEL equals 5 mg/kg/day; Uncertainty Factor (UF) = 100) for use in assessing chronic dietary risk. This chronic RfD is based on the 2- year combined chronic feeding/carcinogenicity study in rats, in which the following effects were observed at the lowest observable adverse effect level (LOAEL) of 100 mg/kg/day in both sexes: statistically significant decreases in body weight gain, changes in renal tubule and kidney function parameters, and increased incidence of male kidney pelvic epithelium hyperplasia.
-- Short- and intermediate-term toxicity. The toxicological endpoint for short- and intermediate-term inhalation risk assessments is a maternal/developmental no observable adverse effect level (NOAEL) of 10 milligrams/kilograms/day (mg/kg/day) based on the dose-dependent increased abortions, and decreased maternal body weight gain, food consumption, and fecal output in the rabbit oral developmental study.

Ref: Federal Register: March 8, 2000 (Volume 65, Number 46)] [Rules and Regulations] [Page 12129-12134]. Diclosulam; Pesticide Tolerance. Final Rule.
http://www.fluorideaction.org/pesticides/diclosulam.fr.march8.2000.htm

Kidney (click on for all fluorinated pesticides)

Based on oral feeding studies, the primary target organs are the liver and kidney. In a subchronic rat feeding study, the primary target organ is the liver including increased relative organ weight, hepatocellular hypertrophy, and slight multifocal necrosis. Decreased body weight and kidney lesions were also noted. Liver effects were also noted in a subchronic dog study and included increased relative liver weight, centrilobular hepatocellular changes, and hepatocellular necrosis accompanied by elevated ALP, AST, and ALT... In a chronic toxicity/oncogenicity study in the rat, the kidney is identified as a target organ... The kidney was also a target organ in a mouse carcinogenicity study. Among the observed kidney effects were reduced vacuolization in the tubular epithelium, lower absolute and relative kidney weights, and focal dilatation with hyperplasia of the epithelial lining in the cortical tubules.
Ref: Federal Register: March 8, 2000 (Volume 65, Number 46)] [Rules and Regulations] [Page 12129-12134]. Diclosulam; Pesticide Tolerance. Final Rule.

http://www.fluorideaction.org/pesticides/diclosulam.fr.march8.2000.htm

Liver (click on for all fluorinated pesticides)

Based on oral feeding studies, the primary target organs are the liver and kidney. In a subchronic rat feeding study, the primary target organ is the liver including increased relative organ weight, hepatocellular hypertrophy, and slight multifocal necrosis. Decreased body weight and kidney lesions were also noted. Liver effects were also noted in a subchronic dog study and included increased relative liver weight, centrilobular hepatocellular changes, and hepatocellular necrosis accompanied by elevated ALP, AST, and ALT.
Ref: Federal Register. March 8, 2000. Diclosulam; Pesticide Tolerance. Final Rule.
http://www.fluoridealert.org/pesticides/Diclosulam.FR.March8.2000.htm

A  February 17, 2005, check at the Code of Federal Regulations for Diclosulam: this herbicide is permitted in or on 2 food commodities in the United States. The following list identifies these crops for which EPA has set pesticide tolerances. 
[Code of Federal Regulations]
[Title 40, Volume 22]
[Revised as of July 1, 2004]
From the U.S. Government Printing Office via GPO Access
[CITE: 40CFR180.543]
[Page 497]

TITLE 40--PROTECTION OF ENVIRONMENT

CHAPTER I--ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)

PART 180_TOLERANCES AND EXEMPTIONS FROM TOLERANCES FOR PESTICIDE CHEMICALS
IN FOOD--Table of Contents

Subpart C_Specific Tolerances

Sec. 180.543 Diclosulam; tolerances for residues.
(a) General. Tolerances are established for residues of the
herbicide diclosulam [N-(2,6-dichlorophenyl)-5-ethoxy-7-fluoro[1,2,4]
triazolo[1,5-c]pyrimidine-2-sulfonamide] in or on the following raw
agricultural commodities as follows:
Commodity Parts per million
Peanut nutmeat 0.020
Soybean, seed 0.020
(b) Section 18 emergency exemptions. [Reserved]
(c) Tolerances with regional registrations. [Reserved]
(d) Indirect or inadvertent residues. [Reserved]

 

 
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