See:
• Overview
of the June 2007 Draft List of Chemicals for Initial Tier 1 Screening
• June
2007 Draft List of Chemicals for Initial Tier 1 Screening
The following are 6 fluorinated pesticides
included in the first list of US EPA's draft list of chemicals
for Initial Tier 1 Endocrine Disruptor Screening, released on
June 11, 2007
Pesticide name / CAS
# |
US food tolerances |
Adverse effects from
animal studies |
Environmental effects |
Benfluralin
1861-40-1 |
Alfalfa, forage & hay - 0.05 ppm
Clover, forage & hay - 0.05ppm
Clover, hay - 0.05 ppm
Lettuce - 0.05 ppm
Peanut - 0.05 ppm
Trefoil, birdsfoot, forage & hay - 0.05 ppm |
•
See
effects:
Ataxia
Blood
Body Weight Decrease
Cancer. Suggestive Evidence of Carcinogenicity:
LIVER.
Endocrine: Thyroid
Kidney
Liver
Spleen |
Fish: Slightly to Very Highly Toxic
Zooplankton: Moderately to Highly Toxic. |
Bifenthrin
82657-04-3 |
* Permited in or on over 250 food commodities,
such as:
Artichoke, Brassica, Cabbage, Caneberry, Cattle, Citrus
Fruit & Oil, Corn, Cotton, Egg, Eggplant, Goat, Grape,
Hogs, Horse, Lettuce, Milk, Peanut meat (hulls removed),
Pepper (bell and non-bell), Poultry, Potato, Rapeseed, Sheep,
Strawberry, Sweet Potato, Legumes, Cattle, Goat, Hog, Horse,
Poultry, Sheep.
• A tolerance of 0.05 ppm In or on
all food/feed items (other than those covered by a higher
tolerance as a result of use on growing crops) in food/feed
handling establishments.
• A time-limited tolerance for use
in Oregon on orchardgrass, forage and orchardgrass, hay
at 0.05 ppm to expire on December 31, 2009. |
•
See
effects:
Ataxia
Bladder
Body Weight Decrease
Cancer: Possible Human Carcinogen URINARY
BLADDER, LIVER, LUNG
Endocrine:
Ovary/Estrus
Thyroid
Liver
Lung
Tremors/Convulsions
Tumor Promoter |
Very Highly Toxic to Fish and Zooplankton
Very persistent in aquatic sediment
Groundwater pollutant |
Cyfluthrin
68359-37-5 |
• Permitted in or on over 200 food
commodities, including:
Alfalfa, Animal feed, Aspirated grain, Barley, Carrot, Cattle,
Citrus fruit, Corn, Cotton, Processed foods, Egg, Goat,
Grape, Raisin, Hog, Hop, Horse, Milk, Oat (grain), Pepper,
Potato, Poultry, Radishe, Sheep, Sorghum, Sugarcane (Cane),
Sugarcane (Molasses), Sunflower seeds, Tomato, Wheat (grain)
• There are also two tolerances of
0.05 ppm for residues of the insecticide cyfluthrin from
general surface, spot, and/or crack and crevice applications
in
food commodities and in feed commodities
• Several petitions for over 150 new
food tolerances have been requested |
•
See
effects:
Ataxia
Blood
Body Weight Decrease
Bone
Brain
Endocrine:
Adrenal
Ovary
Thymus
Eye - Microphthalmia
Genotoxic
Kidney
Lung
Salivary Glands
Sciatic nerve
Tremors |
Acute Toxicity to Fish and Saltwater Life |
Flutolanil
66332-96-5 |
Permitted in or on 43 food commodities,
including:
Cattle, Egg, Goat, Hog, Horse, Milk, Peanut, Potato, Poultry,
Rice, Sheep |
•
See
effects:
Body Weight Decrease
Bone
Brain
Cholesterol
Endocrine: Thyroid
Eye
Liver
Spleen |
Highly persistent in soil.
Anaerobic Aquatic Metabolism: Flutolanil
had a half-life of >13 years. |
Norflurazon
27314-13-2 |
Permitted in or on 59 food commodities, including:
Alfalfa, Almond, Apple, Apricot, Asparagus, Avocado, Blackberry,
Blueberry, Cattle, Cherry, Citrus Fruit, , Cotton, Filbert,
Goat, Grape, Grass, Hog, Hop (fresh), Horse, Milk, Nectarine,
Peach, Peanut, Pear, Pecan, Plum, Poultry, Raspberry, Sheep,
Soybean, Walnut |
•
See
effects:
Blood
Body Weight Decrease
Bone
Cancer: Possible Human Carcinogen - LIVER
Cholesterol
Endocrine:
Ovary
Thyroid
Uterus
Kidney
Liver
Spleen |
Groundwater Contaminant
California found norflurazon - the third
most popular herbicide used on the state's roadsides - in
9.5% of the wells in 1997, the first time samples were taken.
|
Trifluralin
1582-09-8 |
Permitted in or on 129 food commodities,
including:
Alfalfa hay, Asparagus, Barley, Bean -mung, Carrot, Corn,
Cotton, Cress, Flax, Citrus fruit, Fruit (stone crop Group
12), Grape, Hop, Legume (forage), Nut tree group, Peanut,
Peppermint, Rapeseed seed, Safflower seed, Sorghum, Spearmint,
Sugarcane cane, Sunflower seeds, Vegetable (Curcurbit &
Fruiting groups), Vegetable (leafy), Vegetable (root crop
exc. carrots), Vegetable (seed & pod), Wheat |
•
See
effects:
Anemia
Bladder
Blood
Body Weight Decrease
Bone
Cancer:
• Possible Human Carcinogen - Urinary Bladder, Kidney,
Thyroid, Non-Hodgkin's Lymphoma, Testicular
• Elevated odds ratio for Non-Hodgkin's Lymphoma among
farmers
Dermal
Endocrine:
Testicular
Thyroid
Genotoxicity
Heart
Kidney
Liver
Reproductive |
PBT: Persistent, Bioaccumulative and Toxic
Fish: Highly toxic to Very highly toxic
Amphibians: Slightly toxic to Highly Toxic |
Notes:
• EPA identified an initial list of 64 pesticide active
ingredients to undergo Tier 1 screening in the EDSP. In choosing
which pesticide active ingredients to include on the initial screening
list, EPA gave priority to those that:
1. Appeared in four exposure pathways: food, drinking water,
residential use, and occupational exposure, and
2. Appeared in three exposure pathways where the food and occupational
exposure pathways were represented.
• EPA identified 9 High Production Volume (HPV) chemicals
used as pesticide inerts. The four exposure pathways identified
for HPV/pesticide inert chemicals include: human biological monitoring,
ecological biomonitoring, drinking water, and indoor air.
• Chemical Substances Deferred from Screening. In September
2005, EPA indicated that the following types of chemical substances
may be deferred from initial screening:
* Certain FIFRA List 4 pesticide inerts (i.e., List 4 inerts
are described as “inerts of minimal concern”);
* Most polymers with number average molecular weight greater
than 1,000 daltons;
* Strong mineral acids and bases; and
* Chemicals that are being used as a “positive controls”
to validate the screening assays.
How to Submit Comments to EPA
All comments should be identified by docket identification (ID)
no. EPA-HQ-OPPT-2004-0109.
Publicly available docket materials are available in the electronic
docket, Regulations.gov.
Comments may be submitted by one of the following methods:
• Follow the on-line instructions for submitting comments
found in the electronic docket, Regulations.gov.
• E-mail: oppt.ncic@epa.gov.
• Mail: Document Control Office (7407M), Office of Pollution
Prevention and Toxics (OPPT), Environmental Protection Agency,
1200 Pennsylvania Ave., NW., Washington, DC 20460-0001.
• For further information contact Linda Phillips (phillips.linda@epa.gov
or 202-564-1264).
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