First List of pesticides for
USEPA's Endocrine Disruptor Screening Program
• includes 6 fluorinated pesticides
June 11, 2007
Docket ID: EPA-HQ-OPPT-2004-0109
 
 

See:

Overview of the June 2007 Draft List of Chemicals for Initial Tier 1 Screening

June 2007 Draft List of Chemicals for Initial Tier 1 Screening

The following are 6 fluorinated pesticides included in the first list of US EPA's draft list of chemicals for Initial Tier 1 Endocrine Disruptor Screening, released on June 11, 2007

Pesticide name / CAS # US food tolerances Adverse effects from animal studies Environmental effects

Benfluralin

1861-40-1

Alfalfa, forage & hay - 0.05 ppm
Clover, forage & hay - 0.05ppm
Clover, hay - 0.05 ppm
Lettuce - 0.05 ppm
Peanut - 0.05 ppm
Trefoil, birdsfoot, forage & hay - 0.05 ppm

See effects:

Ataxia
Blood
Body Weight Decrease

Cancer. Suggestive Evidence of Carcinogenicity: LIVER.

Endocrine: Thyroid
Kidney
Liver
Spleen

Fish: Slightly to Very Highly Toxic

Zooplankton: Moderately to Highly Toxic.

Bifenthrin

82657-04-3

* Permited in or on over 250 food commodities, such as:
Artichoke, Brassica, Cabbage, Caneberry, Cattle, Citrus Fruit & Oil, Corn, Cotton, Egg, Eggplant, Goat, Grape, Hogs, Horse, Lettuce, Milk, Peanut meat (hulls removed), Pepper (bell and non-bell), Poultry, Potato, Rapeseed, Sheep, Strawberry, Sweet Potato, Legumes, Cattle, Goat, Hog, Horse, Poultry, Sheep.

• A tolerance of 0.05 ppm In or on all food/feed items (other than those covered by a higher tolerance as a result of use on growing crops) in food/feed handling establishments.

• A time-limited tolerance for use in Oregon on orchardgrass, forage and orchardgrass, hay at 0.05 ppm to expire on December 31, 2009.

See effects:

Ataxia
Bladder
Body Weight Decrease

Cancer: Possible Human Carcinogen URINARY BLADDER, LIVER, LUNG

Endocrine:
Ovary/Estrus
Thyroid

Liver
Lung
Tremors/Convulsions
Tumor Promoter

Very Highly Toxic to Fish and Zooplankton

Very persistent in aquatic sediment

Groundwater pollutant

Cyfluthrin

68359-37-5

• Permitted in or on over 200 food commodities, including:
Alfalfa, Animal feed, Aspirated grain, Barley, Carrot, Cattle, Citrus fruit, Corn, Cotton, Processed foods, Egg, Goat, Grape, Raisin, Hog, Hop, Horse, Milk, Oat (grain), Pepper, Potato, Poultry, Radishe, Sheep, Sorghum, Sugarcane (Cane), Sugarcane (Molasses), Sunflower seeds, Tomato, Wheat (grain)

• There are also two tolerances of 0.05 ppm for residues of the insecticide cyfluthrin from general surface, spot, and/or crack and crevice applications in
food commodities and in feed commodities

• Several petitions for over 150 new food tolerances have been requested

See effects:

Ataxia
Blood
Body Weight Decrease
Bone
Brain

Endocrine:
Adrenal
Ovary
Thymus

Eye - Microphthalmia
Genotoxic
Kidney
Lung
Salivary Glands
Sciatic nerve
Tremors

Acute Toxicity to Fish and Saltwater Life

Flutolanil

66332-96-5

Permitted in or on 43 food commodities, including:
Cattle, Egg, Goat, Hog, Horse, Milk, Peanut, Potato, Poultry, Rice, Sheep

See effects:

Body Weight Decrease
Bone
Brain
Cholesterol
Endocrine: Thyroid
Eye
Liver
Spleen

Highly persistent in soil.

Anaerobic Aquatic Metabolism: Flutolanil had a half-life of >13 years.

Norflurazon

27314-13-2

Permitted in or on 59 food commodities, including:
Alfalfa, Almond, Apple, Apricot, Asparagus, Avocado, Blackberry, Blueberry, Cattle, Cherry, Citrus Fruit, , Cotton, Filbert, Goat, Grape, Grass, Hog, Hop (fresh), Horse, Milk, Nectarine, Peach, Peanut, Pear, Pecan, Plum, Poultry, Raspberry, Sheep, Soybean, Walnut

See effects:

Blood
Body Weight Decrease
Bone

Cancer: Possible Human Carcinogen - LIVER

Cholesterol

Endocrine:
Ovary
Thyroid
Uterus

Kidney
Liver
Spleen

Groundwater Contaminant

California found norflurazon - the third most popular herbicide used on the state's roadsides - in 9.5% of the wells in 1997, the first time samples were taken.

Trifluralin

1582-09-8

Permitted in or on 129 food commodities, including:
Alfalfa hay, Asparagus, Barley, Bean -mung, Carrot, Corn, Cotton, Cress, Flax, Citrus fruit, Fruit (stone crop Group 12), Grape, Hop, Legume (forage), Nut tree group, Peanut, Peppermint, Rapeseed seed, Safflower seed, Sorghum, Spearmint, Sugarcane cane, Sunflower seeds, Vegetable (Curcurbit & Fruiting groups), Vegetable (leafy), Vegetable (root crop exc. carrots), Vegetable (seed & pod), Wheat

See effects:

Anemia
Bladder
Blood
Body Weight Decrease
Bone

Cancer:
• Possible Human Carcinogen - Urinary Bladder, Kidney, Thyroid, Non-Hodgkin's Lymphoma, Testicular
• Elevated odds ratio for Non-Hodgkin's Lymphoma among farmers

Dermal

Endocrine:
Testicular
Thyroid

Genotoxicity
Heart
Kidney
Liver
Reproductive

PBT: Persistent, Bioaccumulative and Toxic

Fish: Highly toxic to Very highly toxic

Amphibians: Slightly toxic to Highly Toxic

Notes:

• EPA identified an initial list of 64 pesticide active ingredients to undergo Tier 1 screening in the EDSP. In choosing which pesticide active ingredients to include on the initial screening list, EPA gave priority to those that:

1. Appeared in four exposure pathways: food, drinking water, residential use, and occupational exposure, and
2. Appeared in three exposure pathways where the food and occupational exposure pathways were represented.

• EPA identified 9 High Production Volume (HPV) chemicals used as pesticide inerts. The four exposure pathways identified for HPV/pesticide inert chemicals include: human biological monitoring, ecological biomonitoring, drinking water, and indoor air.

• Chemical Substances Deferred from Screening. In September 2005, EPA indicated that the following types of chemical substances may be deferred from initial screening:

* Certain FIFRA List 4 pesticide inerts (i.e., List 4 inerts are described as “inerts of minimal concern”);
* Most polymers with number average molecular weight greater than 1,000 daltons;
* Strong mineral acids and bases; and
* Chemicals that are being used as a “positive controls” to validate the screening assays.

How to Submit Comments to EPA
All comments should be identified by docket identification (ID) no. EPA-HQ-OPPT-2004-0109.
Publicly available docket materials are available in the electronic docket, Regulations.gov.
Comments may be submitted by one of the following methods:

• Follow the on-line instructions for submitting comments found in the electronic docket, Regulations.gov.
• E-mail: oppt.ncic@epa.gov.
• Mail: Document Control Office (7407M), Office of Pollution Prevention and Toxics (OPPT), Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460-0001.
• For further information contact Linda Phillips (phillips.linda@epa.gov or 202-564-1264).

 

 
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