use of high doses increases the likelihood that potentially
significant toxic effects will be identified. Findings of
adverse effects in any one species do not necessarily indicate
such effects might be generated in humans. From a conservative
risk assessment perspective however, adverse findings in
animal species are assumed to represent potential effects
in humans, unless convincing evidence of species specificity
Food and Agricultural Organization of the United Nations
This is not an exhaustive list.
When time allows more information will be added.
Herbicide - CAS No.
**411-083 069476 Virgo,
D. M., "Fluazifop-butyl: 55 week oral toxicity study in beagle
dogs," Life Science Research, Stock, Essex, England, 10/15/82.
LSR Report No. 81/ILK019/620. Six dogs/sex/group were dosed for
55 weeks with Fluazifop-butyl, 99.6% purity, by gelatin capsules
at dose levels of 0, 5, 25, and 125 mg/kg/day in a chronic study.
Test article within capsules was dissolved in 0.4 ml/kg corn oil
vehicle. NOEL = 5 mg/kg/day... All
other noteworthy findings were limited to the high dose group,
as follows. Seven 125 mg/kg/day dogs (5 M, 2 F) were killed in
extremis prior to term, generally after at least 29 weeks on study.
Fluazifop-butyl caused ulcerations in the
g.i. tract, specifically in the tongue, lip, mouth lining, stomach
pylorus, or cecum. Ulcerations may have contributed to
low RBC parameters in both sexes (reduced HCT, Hb levels, and
RBC counts, particularly in males)...
Ref: May 20, 2002. SUMMARY OF TOXICOLOGY
DATA FLUAZIFOP-P-BUTYL. California EPA. Department of Pesticide
Regulation. Medical Toxicology Branch.
acid - Wood Preservative
- CAS No. 16961-83-4
-- Rats, oral; 430
mg/ kg (LD 50 ; 2.98 mmol/ kg); Somnolence and/ or general depressed
activity was observed. RTECS* (2000)
-- Rats, Sprague- Dawley albino, oral (via stomach tube); single
doses of 215, 464, 1000, and 2100 mg/ kg (1.49, 3.22, 6.939, and
14.57 mmol/ kg) dissolved in water. Animals were observed for
14 days and then necropsied. With 464 mg/ kg, 3 out of 5 rats
died; at ¥ 1000 mg/ kg, 100% mortality was observed. At ¥ 464
mg/ kg, acute depression was observed. Necropsy showed that animals
in the low- dose group were "grossly normal" and that dead rats
had massive hemorrhages in the entire gastrointestinal
tract. Rhone- Poulenc Inc. (1971)
Ref: Review of Toxicological Literature.
October 2001. Sodium Hexafluorosilicate [CASRN 16893-85-9] and
Fluorosilicic Acid [CASRN 16961-83-4]. Prepared for Scott Masten,
Ph.D. National Institute of Environmental Health Sciences P.O.
Box 12233 Research Triangle Park, North Carolina 27709. Contract
No. N01-ES-65402. Submitted by Karen E. Haneke, M.S. (Principal
Investigator) Bonnie L. Carson, M.S. (Co-Principal Investigator)
Integrated Laboratory Systems P.O. Box 13501 Research Triangle
Park, North Carolina 27709. http://www.fluoridealert.org/pesticides/fluorosilicates.nih.2001.pdf
insect Chemosterilant; now used as a pharmaceutical -
CAS No. 51-21-8
A major use of fluorouracil
is in the palliative treatment of carcinoma of the colon, rectum,
breast, stomach, and pancreas that is not amenable to surgery
or irradiation. The major toxic effects of fluorouracil are on
the normal, rapidly proliferating tissues particularly of the
bone marrow and lining of the gastrointestinal tract. Leukopenia,
predominantly of the granulocytopenic type, thrombocytopenia,
and anemia occur commonly with intravenous fluorouracil therapy
at doses ranging from 6 to 12 mg/kg. Pancytopenia and agranulocytosis
also have occurred.
USEPA/OPPT. Support Document for the Health and Ecological Toxicity
Review of TRI Expansion Chemicals. U. S. Environmental Protection
Agency, Washington, DC (1993). As cited by US EPA in: Federal
Register: January 12, 1994. Part IV.
40 CFR Part 372. Addition of Certain Chemicals; Toxic Chemical
Release Reporting; Community Right-to-Know; Proposed Rule.
ADVERSE EFFECTS ON FETUS: Exposure in first trimester resulted
in skeletal abnormalities; hypoplasia of aorta, lungs, thymus,
and gastrointestinal tract; and urinary
tract abnormalities. Fetus exposed in third trimester had cyanosis
TOXNET profile from Hazardous Substances Data Base.
- Fungicide - CAS No. 112281-77-3
Metbolism nd Toxicokinetics. Tetraconazole
was broadly distributed to all organs and tissues tested, with
the highest level detected in the liver, followed by kidneys,
gonads, brain and bones. Low residual levels
were still detected in the liver and gastrointestinal
tract (sometimes bones) at 72 hr.
2005 - Evaluation of Tetraconazole in the product Domark 40ME
Fungicide. Australian Pesticides and Veterinary Medicines Authority.
- CAS No. 126535-15-7
Groups of 20 artificially
inseminated female rabbits were treated by gavage with 0, 15,
90, 270 or 800 mg/kg bw/d DPX-66037-24 (95.6% purity) on days
7Ð19 of gestation. The NOEL for maternal toxicity was 15 mg/kg
bw/d. At 90 mg/kg bw, body-weight gains were lower than controls
at the beginning of the treatment period. Clinical signs of toxicity
were observed at 270 mg/kg bw/d (stool absent or reduced, small
stool), abortions and evidence of gastrointestinal
effects were found at gross necropsy (ulceration
of gastric mucosa, gaseous distension). Food consumption
was also lower than controls in the 270 and 800 mg/kg bw/d groups...
Dec 3, 1999 - Report on Triflusulfuron methyl. Regulatory Note
REG99-03. Pest Management Regulatory Agency, Health Canada, Ottawa.