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Structure:
Synonyms
4-04-00-03508 (Beilstein Handbook Reference)
BRN 1739375
DF
Difluoro
Difluoromethylphosphine oxide
Methyl difluorophosphite
Methylphosphonic difluoride
Methylphosphonyldifluoride
Phosphonodifluoridic acid, methyl-
Systematic Name
Phosphonic difluoride, methyl-
Molecular Formula
C-H3-F2-O-P
Ref:
ChemIDplus
From Toxline at Toxnet:
Deposition And Clearance Of A Water-Reactive
Vapor, Methylphosphonic Difluoride (Difluoro), Inhaled By Rats
Authors: Dahl AR, Bechtold WE
Source: Toxicology and Applied Pharmacology, Vol. 81, No. 1, pages
58-66, 29 references, 1985
Abstract:
The deposition and clearance of inhaled methylphosphonic-difluoride
(676-99-3) was studied in female F344-rats. Twelve to 16
week old animals were exposed by both inhalation and non inhalation
routes to carbon-14 labeled methylphosphonic-difluoride or its hydrolysis
products. Exposed animals were serially killed and dissected so
that the movement of the radiolabel could be traced over 7 days.
Constants were calculated for relating doses of the difluoride to
various respiratory tract tissues as a function of total deposited
vapor. Total deposition was estimated, and each organ was examined
for amount of radioactivity. The deposition
of inhaled difluoride was mainly in the maxilloturbinates and ethmoturbinates,
and clearance was mainly by mucociliary clearance and swallowing.
The constants indicated that the maxilloturbinates in the anterior
of the nose received more than 4 times the dose received by the
ethmoturbinates, while the trachea and lung received much lower
doses than the nasal tissues. Hydrolysis products cleared rapidly
after non inhalation administration. The authors conclude that the
derived constants may be applicable for calculating doses to respiratory
tract tissues for other inhaled vapors that do not saturate the
mucus.
Keywords:
DCN-140021
Metabolism
Physiology
Lung irritants
Air monitoring
Breathing
Animal studies
Tissue distribution
Lung burden
Air sampling
Lung disorders
Anatomy
CAS Registry Numbers: 676-99-3
Developmental Toxicology of Methylphosphonic
Difluoride (DF).
Authors: Starke WC, Burnett DC, Hilaski RJ, Manthei JH, Heitkamp
DH
Author Address: Chemical Research, Development and Engineering Center,
Aberdeen Proving Ground, MD.
Source: Govt Reports Announcements & Index (GRA&I), Issue
04, 1989
Abstract:
TD3: The teratogenicity of vaporized methlyphosphonic
difluoride (DF) was investigated using the rat and rabbit
as the experimental models. Pregnant rats and rabbits were exposed.
Dams and does exposed exhibited nasal exudate and raspy breathing.
These dams also had significantly lower body weights on the last
three of four weighings. There were, however, no differences between
the control litters and the DF-exposed litters for the parameters:
litter number, mean body weight, mean crown-rump length, visceral
or skeletal malformations. It was concluded that DF is not teratogenic
in the rat or rabbit by the inhalation route at the concentrations
tested. Keywords: Fetus; Teratogenic compounds; Gestation; Organogenesis;
Pregnant. (KT) Technical rept. Oct 85-Apr 86,
Precursors of Munition Chemicals: Permissible
Exposure Limits (PELs).
Authors: Anon
Author Address: National Research Council, Washington, DC. Board on
Environmental Studies and Toxicology.
Source: Govt Reports Announcements & Index (GRA&I), Issue
02, 1993
Abstract:
TD3: In 1987, the U.S. Army asked the National Research Council's
Committee on Toxicology (COT) to review the literature that has been
used as the basis to propose workplace exposure standards for four
precursors of munition chemicals. The four precursors are methylphosphonic
dichloride (DC), methylphosphonic difluoride
(DF), pinacolyl alcohol (PA), and O-ethyl-O-(2-diisopropylaminoethyl)-methylphosphonite
(QL). The Occupational Safety and Health Administration (OSHA) and
American Conference of Governmental Industrial Hygienists (ACGIH)
have not developed permissible exposure limits (PELs) or threshold
limit values (TLVs) for these chemicals. The Army requested the review
by COT to ensure that appropriate exposure standards are developed
to protect workers and private citizens who might be incidentally
exposed during chemical production, transportation, or storage. COT
reviewed the toxicologic data base and the proposed PELs for the four
chemicals and reviewed all the published and unpublished toxico
Keywords:
Occupational exposure
Toxicity
Ammunition
Order Number: NTIS/PB93-112233, 36p
Theoretical Prediction of the Infrared Spectra
of Nerve Agents.
Authors: Hameka HF, Jensen JO
Author Address: Pennsylvania Univ., Philadelphia.
Source: Govt Reports Announcements & Index (GRA&I), Issue
23, 1992
Abstract:
TD3: We present the 6-31G* optimized geometries and the corresponding
vibrational frequencies of the three nerve agents sarin, soman,
and tabun. Subsequently, we correct the computed frequencies of
the three molecules by multiplying the computed frequencies by previously
derived correction factors. We compute the 6-31G* optimized geometries
and vibrational frequencies of methylphosphonic
difluoride and methylphosphonofluoridic acid to derive correction
factors for the P-F stretching and bending vibrational frequencies.
Tabun, Nerve agents, Sarin, ab initio calculation, Soman, Vibrational
frequencies. Final rept. Dec 90-Sep 91.
Keywords:
Acids
Infrared spectra
Nerve agents
Order Number: NTIS/AD-A253 961/7, 30p
Price: NTIS Prices: PC A03/MF A01
Supporting Agency: Chemical Research, Development and Engineering
Center, Aberdeen Proging Ground, MD.
SYNTHESIS OF CARBON-14 METHYLPHOSPHONIC DIFLUORIDE
Authors: BECHTOLD WE, DAHL AR
Source: J LABELLED COMPD RADIOPHARM; 22 (11). 1985.
1181-1186.
Abstract:
BIOSIS COPYRIGHT: BIOL ABS. RRM HUMAN ANTICHOLINESTERASE RADIOPHARMACEUTICAL
Medical Subject Headings (MeSH):
ISOTOPES
RADIATION
AMINO ACIDS
PEPTIDES
PROTEINS
MINERALS
ENZYMES/ANALYSIS
DIAGNOSIS
PATHOLOGY
PHARMACOLOGY
ENVIRONMENTAL POLLUTANTS/POISONING
OCCUPATIONAL DISEASES
OCCUPATIONAL HEALTH SERVICES
HOMINIDAE
Keywords:
Radiation-Radiation and Isotope Techniques
Biochemical Studies-Proteins
Biochemical Studies-Minerals
Enzymes-Methods
Pathology
Pharmacology-General
Toxicology-Environmental and Industrial Toxicology
Public Health: Environmental Health-Occupational Health
Hominidae
CAS Registry Numbers: 676-99-3
Language: English
THE INHIBITION
OF RAT AND GUINEA-PIG CHOLINESTERASES BY ANIONIC HYDROLYSIS PRODUCTS
OF METHYLPHOSPHONIC DIFLUORIDE DIFLUORO
Authors: DAHL AR, HOBBS CH, MARSHALL TC
Source: TOXICOL APPL PHARMACOL; 84 (3). 1986.
561-566.
Abstract:
BIOSIS COPYRIGHT: BIOL ABS. RRM METHYLPHOSPHONOFLUORIDATE FLUORIDE
PESTICIDE NEUROTOXICITY MORTALITY HAZARDOUS MATERIALS
Medical Subject Headings (MeSH):
BIOCHEMISTRY
AMINO ACIDS
PEPTIDES
PROTEINS
MINERALS
ENZYMES/CHEMISTRY
ENZYMES/PHYSIOLOGY
ABDOMEN
CHORDATA
ANIMAL
COMPARATIVE STUDY
PATHOLOGY
NECROSIS/PATHOLOGY
AMINO ACIDS/METABOLISM
PEPTIDES/METABOLISM
PROTEINS/METABOLISM
DIAGNOSIS
RESPIRATORY TRACT DISEASES/DIAGNOSIS
NERVOUS SYSTEM DISEASES/PATHOLOGY
DRUG ADMINISTRATION ROUTES
POISONING
ANIMALS, LABORATORY
HERBICIDES
PEST CONTROL
PESTICIDES
RODENTIA
MURIDAE
Keywords:
Biochemical Studies-General
Biochemical Studies-Proteins
Biochemical Studies-Minerals
Enzymes-Chemical and Physical
Enzymes-Physiological Studies
Chordate Body Regions-Abdomen (1970- )
Pathology
Pathology
Metabolism-Proteins
Respiratory System-General
Nervous System-Pathology
Routes of Immunization
Toxicology-General
Pest Control
Caviidae
Muridae
CAS Registry Numbers:
16984-48-8
16984-48-8
1511-67-7
676-99-3
Language: English
Mass Spectral Data of Trimethylsilyl Esters
of Alkyl and Cycloalkyl Methylphosphonates.
Authors: Wils ER, De Jong AL, Van Baar BL
Author Address: Prins Maurits Lab. TNO, Rijswijk (Netherlands).
Source: Govt Reports Announcements & Index (GRA&I), Issue
01, 2000
Abstract:
TD3: The development of a procedure for the recording of reference
mass spectra of trimethylsilyl (TMS) esters of alkyl and cycloalkyl
methylphosphonates is described. The compounds are prepared in situ,
on a small scale, from methylphosphonic difluoride
and a selected alcohol dissolved in acetonitrile. Hydrolysis of
the formed alkyl and cycloalkylmethylpho sphonofluoridates to the
corresponding methylphosphonates, evaporation to dryness and trimethylsilylation
of the residue produces the TMS esters. The resultant reaction mixture
is analysed by gas chromatography-mass spectrometry. In this way,
electron impact mass spectra of TMS esters of 17 alkyl (ranging
from butyl to nonyl) methylphosphonates and five cycloalkyl methylphosphonates
were recorded.The mass spectra and a short description of the fragmentation
processes of the TMS esters are presented. Final rept. Text in English.
Keywords:
Chemical warfare agents
Mass spectra
Trimethylsilyl esters
Order Number: NTIS/ADA367558, Product
reproduced from digital image. Order this product from NTIS by:
phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries);
fax at (703)605-6900; and email at orders ntis.fedworld.gov. NTIS
is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.,
29p
Price: NTIS Prices: PC A03/MF A01
Year of Publication: 1999
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