Table
1. Health Studies available from The
National Technical Information Service(NTIS)
Order from NTIS by: phone at 1-800-553-NTIS (U.S. customers);
(703)605-6000 (other countries); fax at (703)605-6900; and
email at orders@ntis.gov. NTIS is located at 5285 Port Royal
Road, Springfield, VA, 22161, USA.
These
studies were cited at Toxline at Toxnet on Dec 10, 2004. |
| Order
No. |
Title
/ Date |
Keywords |
CAS
Numbers |
NTIS/OTS0520117
EPA/OTS;
Doc #86-890000973S |
2000
- LETTER
CONCERNING SOME TYPE ILLNESS THAT HAVE AFFECTED AREA EMPLOYEES
|
CONFIDENTIAL
SANITIZED
HEALTH EFFECTS
EPIDEMIOLOGY
MAMMALS
HUMANS
INHALATION |
75-45-6
|
NTIS/OTS0574011
EPA/OTS;
Doc #88000000099 |
2000
- INITIAL SUBMISSION: LETTER FROM ELF ATOCHEM NORTH AMERICA,
INC TO USEPA REPORTING FATALITY DUE TO
MISUSE OF CHLORODIFLUOROMETHANE, DATED 02-15-00
|
ELF
ATOCHEM NA INC
CHLORODIFLUOROMETHANE
HEALTH EFFECTS
CASE REPORT
MAMMALS
HUMANS |
75-45-6
|
NTIS/OTS0520491
EPA/OTS;
Doc #86-890000443 |
2000
- CHLORODIFLUOROMETHANE (CFC 22): LONG
TERM INHALATION STUDY IN THE RAT WITH ATTACHMENTS
CENTRAL
TOXICOL LAB |
IMPERIAL
CHEMIAL INDUS
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
INHALATION |
75-45-6
|
NTIS/OTS0520132
EPA/OTS;
Doc #86-890000988S |
2000
- LETTER
FROM E I DUPONT DE NEMOURS & COMPANY REGARDING DATA AND
INFORMATION ON FREON 22 AND FREON
12 (SANITIZED) |
E I DUPONT
DE NEMOURS & CO
FREON 22 (75-45-6)
HEALTH EFFECTS
INDUSTRIAL HYGIENE |
75-45-6
75-71-8 |
NTIS/OTS0520490
EPA/OTS;
Doc #86-890000442 |
2000
- CHLORODIFLUOROMETHANE (CFC 22):
LONG TERM INHALATION STUDY IN
THE MOUSE WITH ATTACHMENTS
CENTRAL
TOXICOL LAB
|
IMPERIAL
CHEMICAL INDUS
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
MICE
INHALATION
|
75-45-6
|
NTIS/OTS0520116
EPA/OTS;
Doc #86-890000972S |
2000
- TOXICITY OF REFRIGERANTS (SANITIZED) |
Acute inhalation
toxicity was evaluated in guinea pigs (sex, strain, and number
not reported) receiving chlorodifluoromethane at concentration
levels of 4.4% (v/v) for 6 hours and 5.2 or 20.3% (v/v) for
2 hours. No mortalities were reported. Slight labored breathing,
and shivering were noted in 1 animal of the 4.4% group. At 5.2%
there were occasional chewing movements, partially closed eyes,
irregular breathing, shaking of heads, and rubbing of noses
with feet. All animals at this exposure level recovered (time
of recovery not reported). At 20.3% animals showed inability
to stand, convulsive leg movements, tremors, lacrimation,
nasal discharge, and audible breathing. All recovered within
1 day of exposure. Gross necropsy findings were not reported. |
SANITIZED
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
GUINEA PIGS
INHALATION
75-45-6
|
NTIS/OTS0520493
EPA/OTS;
Doc #86-890000445 |
2000
- ARCTON 22: METABOLISM STUDY IN VIVO
IN RATS AND IN VITRO WITH ATTACHMENTS
CENTRAL
TOXICOL LAB |
IMPERIAL
CHEMIAL INDUS
ARCTON 22 (75-45-6)
HEALTH EFFECTS
PHARMACO KINETICS
MAMMALS
RATS
INHALATION
IN VITRO |
75-45-6
|
NTIS/OTS0520496
EPA/OTS;
Doc #86-890000448 |
2000
- ARCTON 22: SECOND DOMINANT LETHAL
STUDY IN THE MOUSE WITH ATTACHMENTS
CENTRAL
TOXICOL LAB |
The dominant
lethal effects of chlorodifluoromethane were evaluated in 6
groups of 20 fertile male CD-1 mice exposed by inhalation to
chlorodifluoromethane (Arcton 22) at nominal concentrations
of 10, 100, 500, 1000, 10000, or 50000 ppm for 6 hours/day,
for 5 consecutive days. A group of 40 male mice served as the
untreated control. A group of 20 mice injected once intraperitoneally
with 200 mg/kg cyclophosphamide served as the positive control.
Mating followed the final treatment period. Each male mouse
in each treatment group was paired with 2 virgin female 10-week
old mice, during 8 consecutive 4-day mating periods, commencing
at 7-day intervals. A significant reduction
in the percentage of females which became pregnant occurred
in the 5th mating period in females mated to males in the 10,000
and 50,000 ppm exposure groups. The
number of successful matings per male was statistically significantly
reduced in the 10 ppm exposure group in weeks 4 and 7, in the
10,000 ppm group in week 5, and in the 50,000 ppm group in weeks
1, 5, and 7. The time of sacrifice of the mated females
was not reported. The number of implantations
per pregnancy was significantly reduced in females mated to
males in the 100 ppm exposure group (week 4), in the 500 ppm
group (week 6), and in the 1000 ppm exposure group (week 5).
All treated groups except the 10,000 ppm group had a significant
increase in early deaths. Late deaths were significantly increased
in pups of females mated in week 4 (100, 1000, and 50000 ppm)
and in week 7 (50000 ppm). |
Keywords:
IMPERIAL CHEMICAL INDUS
ARCTON 22 (75-45-6)
HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS
MAMMALS
MICE
INHALATION
75-45-6
|
NTIS/OTS0514917
EPA/OTS;
Doc #86-870001015 |
2000-
CARDIAC SENSITIZATION IN DOGS |
E.I.
DUPONT DE NEMOURS & CO
PROPANE (74-98-6)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
INHALATION |
74-98-6
75-00-3
75-37-6
75-45-6
75-68-3
76-15-3
115-10-6
127-18-4 |
NTIS/OTS0520484
EPA/OTS;
Doc #86-890000436 |
2000
-
FLUOROCHLOROCARBONS: A SUMMARY REPORT OF THE FINDINGS FROM
SHORT-TERM PREDICTIVE TESTS AND LONG-TERM
RAT CARCINOGENICITY STUDIES WITH ATTACHMENTS
CENTRAL
TOXICOL LAB
|
IMPERIAL
CHEMICAL INDUS
CHLOROFLUOROMETHANE (593-70-4)
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
ORAL
GAVAGE |
75-45-6
593-70-4 |
NTIS/OTS0520485
EPA/OTS;
Doc #86-890000437 |
2000
-
MUTAGENICITY TESTING WITH SALMONELLA
TYPHIMURIUM STRAINS ON PLATES, OF GASES, LIQUIDS AND SOLIDS
FOR IMPERIAL CHEMICAL INDUSTRIES LIMITIED WITH ATTACHMENTS
CENTRAL
TOXICOL LAB
|
IMPERIAL
CHEMICAL INDUS
CARBON TETRACHLORIDE (56-23-5)
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO |
56-23-5
68-12-2
75-01-4
75-09-2
75-10-5
75-43-4
75-45-6
75-68-3
75-88-7
96-45-7
127-19-5
420-46-2
593-70-4
680-31-9 |
NTIS/OTS0520492
EPA/OTS;
Doc #86-890000444 |
2000
- ARCTON 22: A SECOND CYTOGENETIC STUDY
IN THE RAT WITH ATTACHMENTS
CENTRAL TOXICOL LAB |
The frequency
of chromosome aberrations was determined in bone marrow cells
of Wistar-derived male rats exposed by inhalation to chlorodifluoromethane
(Arcton 22) for 6 hours/day over 5 consecutive days. Five groups
of 12 male rats (150 to 200g; 8 to 10 weeks old) were exposed
to nominal concentrations of 0, 10, 100, 500, and 1000 ppm of
Arcton 22. A positive control group of 12 rats was exposed to
4000 ppm benzene. Cell division was arrested 4 hours after the
final exposure with an intraperitoneal injection of colchicine
(3 mg/kg). Rats were sacrificed 6 hours after the final exposure,
and fifty cells from each animal were examined. The proportion
of cells with any abnormality, and the proportion of cells with
any abnormality except gaps, were compared with the negative
control group using ANOVA (data were arcsine-transformed). The
proportion of animals with any abnormality except gaps was compared
with the negative control using Fisher's exact test. There was
an inverse dose-response relationship between treated groups.
The mean percentage of bone marrow cells
with chromosomal abnormalities (other than gaps) was significantly
different in the group nominally exposed to 10 ppm, but not
at higher concentrations. The percentage of rats with chromosomal
abnormalities (except gaps) was elevated in groups exposed to
all but the highest concentration. |
MPERIAL
CHEMICAL INDUS
ARCTON 22 (75-45-6)
HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS
MAMMALS
RATS
INHALATION
75-45-6
|
NTIS/OTS0520494
EPA/OTS;
Doc #86-890000446 |
2000
- ARCTON 22: CYTOGENETIC STUDY IN THE
RAT WITH ATTACHMENTS
CENTRAL
TOXICOL LAB
|
IMPERIAL
CHEMICAL INDUS
ARCTON 22 (75-45-6)
HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS
MAMMALS
RATS
INHALATION |
75-45-6
|
NTIS/OTS0540606
EPA/OTS;
Doc #88-920004258 |
1992
- INITIAL SUBMISSION: EMBRYOTOXIC AND
TERATOGENIC STUDIES IN RATS WITH INHALED CHLORODIFLUOROMETHANE
WITH COVER LETTER DATED 06-15-92 AND
ATTACHMENTS
HASKELL
LABORATORY |
Chlorodifluoromethane
(FC-22) was evaluated for embyotoxicity and teratogenicity
in groups of 40 pregnant Charles River rats exposed to the
test substance by inhalation at concentrations of 0, 0.05,
0.10, and 2.00% on days 6-15 of gestation. No clinical signs
of toxicity were observed in maternal animals. The number
of implantations, early and late resorptions, and number of
live fetuses per litter were unaffected. There
was a sporadic appearance of major malformations of the eye
in all test groups. The increased incidence of eye
defects was not statistically significant. Authors believe
that the test substance may have interacted with the genetic
make-up of affected fetuses and caused the increased expressivity
of a mutant gene. The
authors considered the test substance to be a mutagen under
the conditions of this study.
•
Note from FAN: Anophthalmic definition:
Absence of an eye(s). It can be a congenital (born
without) or an acquired condition (surgically removed).
Keywords:
E I DUPONT DE NEMOURS & CO
CHLORODIFLUOROMETHANE
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION |
75-45-6
|
NTIS/OTS0545682
EPA/OTS;
Doc #88-920007428 |
1992
- ANOPHTHALMIA AND MICROPHTALMIA WITH
COVER LETTER DATED 08-28-92
HUNTINGDON
RES CNTR |
ICI
AMERS INC
ARCTON 22
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION |
75-45-6
|
NTIS/OTS0555242
EPA/OTS;
Doc #88-920008820 |
1992
- INITIAL SUBMISSION: EMBRYTOXICITY
AND TERATOGENIC STUDIES IN RATS WITH INHALED CHLOROFLUOROMETHANE
(FC-22) WITH COVER LETTER DATED 09/02/92
HASKELL
LABORATORY
|
E
I DUPONT DE NEMOURS & CO
CHLORODIFLUOROMETHANE
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY |
75-45-6
|
NTIS/OTS0538018
EPA/OTS;
Doc #88-920001373 |
1992
- INITIAL SUBMISSION: REPORT COVER LETTER REGARDING HUMAN
LIVER TEST ABNORMALITIES IN RELATION TO ACETONE, 1,1,1
TRICHLOROETHANE, FREON AND OTHER SOLVENTS DATED 031192
|
HONEYWELL
INC
1,1,1 TRICHLOROETHANE
HEALTH EFFECTS
CASE REPORT |
67-64-1
71-55-6
75-45-6 |
NTIS/OTS0545690
EPA/OTS;
Doc #88-920007436 |
1992
- INITIAL SUBMISSION: ARCTON 22: CYTOGENIC
STUDY IN THE RAT WITH COVER LETTER DATED
08-28-92
IMPERIAL CHEM INDUS LTD
|
ICI
AMERS INC
CHLORODIFLUOROMETHANE
HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS
MAMMALS
RATS
INHALATION |
75-45-6
|
NTIS/OTS0545700
EPA/OTS;
Doc #88-920007446 |
1992
- INITIAL SUBMISSION: ARCTON 22: A SECOND
CYTOGENETIC STUDY IN THE RAT WITH COVER LETTER DATED
08-28-92
IMPERIAL
CHEM INDUS LTD
|
ICI
AMERS INC
ARCTON 22
HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS
MAMMALS
RATS
INHALATION |
75-45-6
|
NTIS/OTS0545691
EPA/OTS;
Doc #88-920007437 |
1992
- INITIAL SUBMISSION: ARCTON 22: SECOND
DOMINANT LETHAL DOSE STUDY IN THE MOUSE & DOMINANT
LETHAL STUDY IN THE MOUSE WITH COVER LETTER DATED 08-28-92
IMPERIAL
CHEM INDUS LTD |
Keywords:
ICI AMERS INC
ARCTON 22
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
MAMMALS
MICE
INHALATION |
75-45-6
|
NTIS/PB92-193697
14p |
1992
- Fatal
Accident Circumstances and Epidemiology (FACE) Report: Assistant
Manager at Ice Rink Asphyxiated by an Oxygen-Deficient Atmosphere,
Alaska, May 20, 1991.
National
Inst. for Occupational Safety and Health, Morgantown, WV.
Div. of Safety Research.
|
The case
of a 24 year old male assistant manager for a shopping mall
ice skating rink who was asphyxiated inside a compressor room
while attempting to shut off a refrigerant gas leak was examined.
The gas was chlorodifluoromethane-22 (75-45-6)
(CFC-22). The employer was the owner of a 170 store indoor shopping
mall which included a swimming pool and an ice skating rink.
There was no safety policy or program in place. The refrigeration
system had a long history of leaks. A large leak had been plugged
in a makeshift fashion. A maintenance worker performing a routine
check observed refrigerant oil oozing from under the doors to
the compressor room. The victim, the maintenance supervisor,
and a maintenance worker entered the compressor room through
self closing doors. The victim was wearing a cartridge type
respirator which was inadequate in an oxygen deficient atmosphere.
A coworker called 911 after entering the compressor room and
seeing two of the workers lying on the floor. The maintenance
worker [abstract
truncated] |
Occupational
safety and health
Industrial safety
Safety measures
Environmental surveys
Toxic substances
Fatal Accident Circumstances and Epidemiology
75-45-6 |
NTIS/OTS0555876
EPA/OTS;
Doc #88-920010607 |
1992
-
INITIAL SUBMISSION: CARDIAC SENSITIZATION
STUDY OF DICHLORODIFLUOROMETHANE, CHLORODIFLUOROMETHANE, 1,2-DICHLOROTETRAFLUOROETHANE,
* IN DOGS WITH COVER LETTER DATED 10/15/92
HASKELL
LABORATORY |
E
I DUPONT DE NEMOURS & CO
DICHLORODIFLUOROMETHANE, CHLORODIFLUOROMETHANE, 1,2-DICHLOR*
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
INHALATION
NEUROTOXICITY
BIOCHEMISTRY |
71-55-6
75-28-5
75-45-6
75-71-8
76-14-2
115-25-3 |
NTIS/OTS0546572
EPA/OTS;
Doc #88-920010187 |
1992 - INITIAL SUBMISSION: CARDIAC
SENSITIZATION TEST IN DOGS WITH COVER LETTER DATED 10-15-92
HASKELL
LABS |
DUPONT
CHEM CO
FREON COMPOUNDS
HEALTH EFFECTS
BIOCHEMISTRY
MAMMALS
DOGS
INHALATION |
71-55-6
75-28-5
75-45-6
75-71-8
76-14-2
76-15-3
115-25-3 |
NTIS/OTS0570941
EPA/OTS;
Doc #88-920008896 |
1992 - INITIAL SUBMISSION: LETTER
FROM DUPONT CHEM TO USEPA REGARDING CARDIAC
SENSITIZATION STUDIES OF FREON COMPOUNDS IN DOGS WITH ATTACHMENTS
AND COVER LETTER DATED 09-02-92
HASKELL
LABORATORY |
DUPONT
CHEM
FREON COMPOUNDS
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
PARENTERAL
INTRAPERITONEAL
INHALATION |
51-43-4
71-55-6
75-28-5
75-45-6
75-71-8
76-14-2
76-15-3
115-25-3 |
NTIS/OTS0545701
EPA/OTS;
Doc #88-920007447 |
1992
- INITIAL SUBMISSION: CHLORODIFLUOROMETHANE (CFC): LONG-TERM
INHALATION STUDY IN THE RAT WITH COVER LETTER DATED
08-28-92
IMPERIAL
CHEM INDUS LTD |
ICI
AMERS INC
CHLORODIFLUOROMETHANE
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
INHALATION |
75-45-6
|
NTIS/OTS0546355
EPA/OTS;
Doc #88-920008934 |
1992
- INITIAL SUBMISSION: EMBRYONIC AND
TERATOGENICITY STUDIES IN THE RAT WITH INHALED CHLORODIFLUOROMETHANE(FC-22)
WITH COVER LETTER DATED 09-02-92
HASKELL
LABS |
DUPONT
CHEM CO
CHLORODIFLUOROMETHANE(FC-22)
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION |
75-45-6
|
NTIS/OTS05563292
EPA/OTS;
Doc #88-920010933 |
1992
- INITIAL SUBMISSION: INHALATION TOXICITY STUDY OF FLUOR CHLOR
REFRIGERANTS IN THE GUINEA PIGS
WITH COVER LETTER DATED 10-18-92 |
E
I DUPONT DE NEMOURS & CO
MONO-CHLORO-MONO-FLUORO-METHANE; DIFLUORO METHANE; MONO-CHL*
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
GUINEA PIGS
INHALATION
SUBCHRONIC TOXICITY
NEUROTOXICITY
BIOCHEMISTRY |
75-10-5
75-45-6
593-70-4 |
NTIS/OTS0555047
EPA/OTS;
Doc #88-920008229 |
1992
- INITIAL SUBMISSION: ACUTE INHALATION TOXICITY STUDY OF DETOXIFIED
HIGH BOILERS (FREON 22 PYROLYSIS PRODUCTS)
IN RATS WITH COVER LETTER DATED 09/01/92
TNO
NUTRITION AND FOOD RESEARC
|
E
I DUPONT DE NEMOURS & CO
"FREON" 22 PYROLYSIS PRODUCTS/DETOXIFIED
HIGH HIGH BOILERS
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
RABBITS
|
75-45-6
|
NTIS/OTS0571901
EPA/OTS;
Doc #88-920010755 |
1992
-
INITIAL SUBMISSION: TOXICITY TESTING
SUMMARY FOR ALTERNATIVE FLUOROCARBONS WITH COVER LETTER
DATED 08-24-92
DUPONT
CHEM
|
PHILLIPS
PETROLEUM CO
FLUOROCARBONS
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
CHRONIC TOXICITY
CARCINOGENICITY
DOGS
PRIMARY EYE IRRITATION
RABBITS
DERMAL
PRIMARY DERMAL IRRITATION
GUINEA PIGS
PRIMARY DERMAL SENSITIZATION |
75-10-5
75-37-6
75-43-4
75-45-6
75-68-3
75-88-7
306-83-2
593-70-4
811-97-2
2837-89-0 |
NTIS/OTS0522350
EPA/OTS;
Doc #86-900000094 |
1990
-
A STUDY OF THE RATE OF UPTAKE AND ELIMINATION
OF CHLORODIFLUOROMETHANE (HFA22) IN MAN BY THE INHALATION
ROUTE WITH COVER LETTER DATED 02-07-90
ICI
CENTRAL TOXICOL LAB |
HFA22 (chlorodifluoromethane)
was evaluated for pharmacokinetics in groups of 3 male humans
exposed via inhalation to vapor concentrations of 92 or 518
ppm for 4 hours in an inhalation chamber. Blood and expired
air samples were taken during exposure and for up to 26 hours
after exposure. Urine samples were taken for up to 22 hours
after exposure. The compound was absorbed very quickly, reaching
plateaus of 0.25 and 1.36 ug/ml after approximately 4 and 3
hours of exposure for the low- and high-dose levels, respectively.
End-tidal breath concentrations of the test compound during
exposure were similar to the exposure concentration
s, indicating that only a small proportion of the available
dose was absorbed. Elimination of the compound from blood was
triphasic, with estimated half-lives of 0.005, 0.20, and 2.7
hours. The first phase probably corresponded to elimination
from blood and rapidly perfused tissues, whereas the second
and third phases of elimination probably corresponded to elimination
from slowly perfused tissues and fat, respectively. The parent
compound was detected in urine samples from all subjects; very
little fluoride ion was detected in urine samples, indicating
that the test compound was probably not metabolized to a significant
extent.
|
Keywords:
ICI AMERICAS INC
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
PHARMACO KINETICS
MAMMALS
HUMANS
INHALATION
75-45-6
|
NTIS/OTS0522351
EPA/OTS;
Doc #86-900000095 |
1990
- ARCTON 22: AN EVALUATION IN THE MOUSE
MICRONUCLEUS TEST WITH COVER LETTER DATED 02-07-90
ICI CENTRAL TOXICOL LAB
|
Arcton
22 (chlorodifluoromethane) was evaluated for clastogenicity
in C57BL/6JfCD-1/Alpk mice exposed to vapor concentrations of
0 (5 mice/sex), 50,000 (5 mice/sex) or 150,000 ppm (15 mice/sex)
for 6 hours in a dynamic air-flow chamber. Mice were sacrificed
and bone marrow was examined for micronucleated polychromatic
erythrocytes at 24 hours after treatment with 50,000 ppm, and
24, 48, or 72 hours after treatment with 150,000 ppm. The frequency
of micronucleated polychromatic erythrocytes did not increase
in any of the treatment groups, indicating that Arcton 22 was
not clastogenic in mice under the conditions of this assay. |
Keywords:
ICI AMERICAS INC
ARCTON 22 (75-45-6)
HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS
MAMMALS
MICE
INHALATION
CAS Registry
Numbers:
75-45-6 |
NTIS/OTS0526005
EPA/OTS;
Doc #86-900000425 |
1990
-
ACUTE
(4-HOUR) INHALATION TOXICITY STUDY WITH HHB UNTREATED AND
HHB TREATED IN RATS WITH COVER LETTER
CIVO
INSTITUTE TNO
|
E
I DUPONT DENEMOURS & CO INC
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION |
75-45-6
|
NTIS/OTS0520413
EPA/OTS;
Doc #87-890000011 |
1989
-
EFFECT
OF ACRTON 22 ON PREGNANT RATS: RELATIONSHIP TO ANOPHTHALMIA
AND MICROPHTHALMIA WITH ATTACHMENTS AND COVER LETTER
DATED 07-05-89
|
Teratogenicity
was evaluated in 4 groups of 19 pregnant CD female rats receiving
Arcton 22 via inhalation at concentration levels of 0, 100,
1,000 and 50,000 ppm for 6 hours per day on gestation days 6
through 15. There were no treatment-related effects in appearance,
behavior, mortality, or pregnancy rate. At 50,000 ppm maternal
weight gain was slightly lower than the control. There were
no effects on body weight at 100 or 1,000 ppm. In all test groups
litter size, post-implantation loss, litter wight, and mean
fetal weight were similar to the control. At
50,000, there was an increased incidence of anophthalmic fetuses. |
Keywords:
ICI LTD
ARCTON 22 (75-45-6)
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION
CAS Registry Numbers:
75-45-6 |
NTIS/OTS0520410
EPA/OTS;
Doc #87-890000008 |
1989
- INHALATION EXPOSURE WITH COVER LETTER DATED
07-05-89
CENTRAL
TOXICOL LAB |
MPERIAL
CHEM INDUS LTD
ARCTON 22 (75-45-6)
HEALTH EFFECTS
BIOCHEMISTRY
MAMMALS
RATS
INHALATION |
75-45-6
|
NTIS/OTS0520989
EPA/OTS;
Doc #86-890000874S |
1989
- EMBRYOTOXIC AND TERATOGENIC STUDIES
IN RAT WITH INHALED CHLORODIFLUOROMETHANE (FC-22) WITH
COVER SHEET DATED 06-12-89 (SANITIZED)
HASKELL
LABORATORIES
|
E
I DUPONT DE NEMOURS & CO
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY |
75-45-6
|
NTIS/OTS0520990
EPA/OTS;
Doc #86-890000875S |
1989
-
EMBRYOTOXIC AND TERATOGENIC STUDIES
IN RATS WITH INHALED CHLORODIFLUOROMETHANE (FC-22)
WITH ATTACHMENTS AND COVER SHEET DATED 06-12-89
(SANITIZED)
HASKELL
LABORATORIES |
E
I DUPONT DE NEMOURS & CO
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY |
75-45-6
|
NTIS/OTS0520412
EPA/OTS;
Doc #87-890000010 |
1989
-
EFFECT OF
ARCTON 22 ON PREGNANCY OF THE NEW ZEALAND WHITE RABBIT WITH
ATTACHMENTS AND COVER LETTER DATED 07-05-89
|
Teratogenicity
was evaluated in 4 groups of 14 to 16 pregnant New Zealand white
female rabbits receiving Arcton 22 (chlorodifluoromethane) via
inhalation at concentration levels of 0, 100, 1,000 and 50,000
ppm for 6 hours per day on gestation days 6 through 18. There
were no signs of treatment-related effects on mortality or pregnancy
rate. At the highest concentration level there was slight weight
loss during the first 4 days of exposure, but weight gains were
comparable to controls. Litter values (determined by litter
size, implantation loss, litter and mean fetal weights) were
similar to the control at all exposure levels.
There were no signs of treatment-related embryonic or fetal
malformations noted. Parameters such as the number of corpora
lutea, implantations per dam, resorption rates, fetal weights
and or sex distribution were not reported |
Keywords:
ICI LTD
ARCTON 22 (75-45-6)
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RABBITS
INHALATION
CAS Registry
Numbers:
75-45-6 |
NTIS/OTS0516686
EPA/OTS;
Doc #86-890000160 |
1989
-
DATENBLATT ALTSTOFFE TOXICOLOGICAL PROFILES
FOR 3 CHEMICALS WITH COVER LETTER DATED 03-17-89
|
HOECHST
CELANESE CORP
4-NITROPHENOL (100-02-7)
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION
DOGS
ENVIRONMENTAL EFFECTS
ACUTE TOXICITY
FISH-FRESHWATER
ALGAE
INVERTEBRATES
BACTERIA
GENOTOXICITY
GENE MUTATIONS
IN VITRO
ORAL
DERMAL
PRIMARY DERMAL IRRITATION
RABBITS
PRIMARY EYE IRRITATION |
75-45-6
76-13-1
100-02-7 |
NTIS/OTS0520835
EPA/OTS;
Doc #86-890001332 |
1989
-
LETTER FROM ICI AMERICAS INCORPORATED
TO THE USEPA CONCERNING CHLORODIFLUOROMETHANE LONG-TERRM
INHALATION STUDY WITH COVER SHEETS AND LETTER DATED 07-24-89
|
ICI
AMERICAS INC
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
CHRONIC TOXICITY
CARCINOGENICITY
MAMMALS
RATS
INHALATION
MICE |
75-45-6
|
NTIS/OTS0520838
EPA/OTS;
Doc #86-890001335 |
1989
- TOXICITY REVIEW OF FREON 22
- CHLORODIFLUOROMETHANE WITH COVER SHEETS AND LETTER DATED
07-24-89
HASKELL
CORPORATION
|
E
I DUPONT DE NEMOURS & CO
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY
GUINEA PIGS
DOGS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
HAMSTERS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY |
75-45-6
|
NTIS/OTS0520993
EPA/OTS;
Doc #86-890000878 |
1989
- CHINESE HAMSTER OVARY CELL ASSAY FOR MUTAGENICITY WITH ATTACHMENTS
AND COVER SHEET DATED 06-12-89
HASKELL
LABORATORIES |
The ability
of chlorodifluoromethane to cause mutation at the gene locus
coding for hypoxanthine-guanine phosphoribosyl transferase in
Chinese hamster ovary cells (CHO/HGPRT Assay) was evaluated
in the presence and absence of metabolic activation from Aroclor-induced
rat liver S9 fraction. Results of preliminary toxicity tests
of non-activated cultures treated with concentrations of 0,
20, 31, 33, 58, 60, 73, 75, 83, and 92% chlorodifluoromethane
produced plating efficiences ranging from 115.9 to 93.2% relative
to the nitrogen gas control. Assays of activated cultures at
concentrations of 0, 32, 36, 60, 70, 76, 78, 81, and 82% produced
cloning efficiencies ranging from 109.9 to 78.3% relative to
the nitrogen gas control. Neither the activated nor non-activated
cultures exhibited a significant increase in mutant frequency
relative to the negative control. |
Keywords:
E I DUPONT DE NEMOURS & CO
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
MAMMALS
HAMSTERS
IN VITRO
75-45-6 |
NTIS/OTS0520411
EPA/OTS;
Doc #87-890000009 |
1989
- ARCTON 22 (CHLORODIFLUOROMETHANE) - RELATIONSHIP BETWEEN
BLOOD LEVELS AND INHALED CONCENTRATIONS
IN ANAESTHETISED, ARTIFICALLY-VENTILATED RATS WITH COVER LETTER
DATED 07-05-89
CENTRAL
TOXICOL LAB |
IMPERIAL
CHEM INDUS LTD
ARCTON 22 (75-45-6)
HEALTH EFFECTS
BIOCHEMISTRY
MAMMALS
RATS
INHALATION |
75-45-6 |
NTIS/OTS0520992
EPA/OTS;
Doc #86-890000877 |
1989
- MUTAGENIC ACTIVITY OF CHLORODIFLUOROMETHANE IN THE SALMONELLA/MICROSOME
ASSAY WITH ATTACHMENTS AND COVER SHEET DATED 06-12-89
HASKELL
LABORATORIES |
The
mutagenicity of chlorodifluoromethane was evaluated in Salmonella
tester strains TA98, TA100, TA1535, and TA1537 (Ames Test),
both in the presence and absence of added metabolic activation
by Aroclor-induced rat liver S9 fraction. Based on the results
of preliminary bacterial toxicity testing, the material was
tested for mutagenicity at concentrations of 0, 15, 25, and
40% (of the atmosphere) using the dessicator method. The material
caused a reproducible positive response in tester strain TA1535,
both in the presence and absence of S9 activation. Chlorodifluoromethane
did not cause a reproducible positive response in tester strains
TA98, TA100, and TA1537, either in the presence or absence
of added metabolic activation.
Keywords:
E I DUPONT DE NEMOURS & CO
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO |
75-45-6 |
NTIS/OTS0520991
EPA/OTS;
Doc #86-890000876 |
1989
- IN VITRO MICROBIAL MUTAGENICITY STUDIES OF CHLORODIFLUOROMETHANEWITH
ATTACHMENTS AND COVER SHEET DATED 612-89
HASKELL
LABORATORIES
|
The
mutagenicity of chlorodifluoromethane was evaluated in Salmonella
tester strains TA98, TA100, TA1535, TA1537, and TA1538 (Ames
Test), both in the presence and absence of added metabolic
activation by Aroclor-induced rat liver S9 fraction. Based
on the results of preliminary bacterial toxicity testing,
the material was tested for mutagenicity at concentrations
of 0, 20, and 40% (of the atmosphere) using the dessicator
method. Chlorodifluoromethane did not cause a reproducible
positive response in any of the bacterial tester strains,
either in the presence or absence of added metabolic activation.
|
Keywords:
E I DUPONT DE NEMOURS & CO
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
75-45-6
|
NTIS/OTS0520424
EPA/OTS;
Doc #86-890000318 |
1989
- A TABLE OF ACUTE ORAL AND DERMAL
LD50'S AND INHALATION LD50'S FOR FLUOROCARBON-11, 12, 22,
113, 114, 115, AND 152A WITH ATTACHMENTS AND COVER LETTER
DATED 06-09-89
HASKELL
LABORATORIES
|
E
I DUPONT DE NEMOURS & CO
FLUOROCARBON 152A (75-37-6)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
PHARMACO KINETICS
SUBCHRONIC TOXICITY
ORAL
RABBITS
DERMAL |
75-37-6
75-45-6
75-69-4
75-71-8
76-13-1
76-14-2
76-15-3 |
NTIS/OTS0520425
EPA/OTS;
Doc #86-890000319 |
1989
- A TABLE OF ACUTE ORAL, AND DERMAL
LD50'S AND INHALATION LD50'S FOR FC-11, 12, 22, 113, 114,
115, AND 152A WITH ATTACHMENTS AND COVER LETTER DATED 06-09-89
HASKELL
LABORATORIES
|
E
I DUPONT DE NEMOURS & CO
FLUOROCARBON 152A (75-68-3)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
PHARMACO KINETICS
SUBCHRONIC TOXICITY
ORAL
RABBITS
DERMAL |
75-37-6
75-45-6
75-69-4
75-71-8
76-13-1
76-14-2
76-15-3 |
NTIS/OTS0520218
EPA/OTS;
Doc #86-890001075 |
1989
- LETTER REGARDING THE REQUESTED INFORMATION ON ATMOSPHERIC
LIFETIMES AND OZONE DEPLETION POTENTIALS
CALCULATED USING 1-D MODELS WITH ATTACHMENTS AND COVER LETTER
07-10-89
|
E
I DUPONT DE NEMOURS & CO
CHLOROFLUOROCARBONS (75-45-6)
ENVIRONMENTAL FATE |
56-23-5
75-45-6
75-69-4
75-71-8
76-13-1
76-14-2
76-15-3
306-83-2
431-06-1
2837-89-0
25323-89-1 |
NTIS/OTS0520416
EPA/OTS;
Doc #87-890000014 |
1989
-
FISH TOXICITY OF FRIGENS WITH COVER
LETTER DATED 07-28-89
|
HOECHST
CELANESE CORP
FRIGEN 113 (76-13-1)
ENVIRONMENTAL EFFECTS
ACUTE TOXICITY
FISH-FRESHWATER |
75-45-6
75-69-4
75-71-8
76-13-1
76-14-2 |
NTIS/OTS0520994
EPA/OTS;
Doc #86-890000879 |
1989
-
CARDIAC SENSITIZATION WITH ATTACHMENT
AND COVER SHEET DATED 06-12-89
HASKELL
LABORATORIES |
E
I DUPONT DE NEMOURS & CO
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
INHALATION |
71-55-6
75-28-5
75-45-6
75-71-8
76-14-2
76-15-3
115-25-3 |
NTIS/OTS0000695
EPA/OTS;
Doc #FYI-OTS-0689-0695 |
1989
- ARCTON 134A DOMINANT LETHAL STUDY IN THE MOUSE, EXCRETION,
TISSUE DISTRIBUTION AND METABOLISM IN RAT, TERATOGENICITY,
CYTOGENTIC, AND SUB-ACUTE STUDIES IN RATS WITH LETTER
06-21-89
IMPERIAL
CHEM INUS LTD
|
ICI
PRODUCTS LTD
ARCTON 134A
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
CHRONIC TOXICITY
CARCINOGENICITY
MAMMALS
RATS
ORAL
GAVAGE
CELL TRANSFORMATION
HAMSTERS
CHROMOSOMAL EFFECTS
INHALATION
PHARMACO KINETICS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
SUBCHRONIC TOXICITY
MICE |
75-45-6
75-88-7
420-46-2
593-70-4
811-97-2 |
NTIS/OTS0520837
EPA/OTS;
Doc #86-890001334 |
1989
-
LETTER FROM E I DUPONT DE NEMOURS & COMPANY CONCERNING TOXICITY
REVIEW OF FLUOROCARBON 22 WITH COVER SHEETS AND LETTER
DATED 07-24-89
|
E
I DUPONT DE NEMOURS & CO
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
CHRONIC TOXICITY
CARCINOGENICITY
MAMMALS
RATS
INHALATION
MICE |
75-45-6
|
NTIS/OTS0520423
EPA/OTS;
Doc #86-890000317 |
1989
-
HEALTH & SAFETY STUDIES ON ISOTRON 142B, ISOTRON 22, FLUOROCARBON
152A AND ISOTRON 113 WITH ATTACHED APPENDICES AND COVER LETTER
DATED 06-09-89
CENTRAL
TOXICOL LAB
|
PENWALT
CORP
ISOTRON 142B (75-68-3)
HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS
MAMMALS
MICE
INHALATION
RATS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
PHARMACO KINETICS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
RABBITS
SUBCHRONIC TOXICITY
GUINEA PIGS
IN VITRO |
75-45-6
|
NTIS/OTS0520424
EPA/OTS;
Doc #86-890000318 |
1989
- A TABLE OF ACUTE ORAL AND DERMAL LD50'S
AND INHALATION LD50'S FOR FLUOROCARBON-11, 12, 22,
113, 114, 115, AND 152A WITH ATTACHMENTS AND COVER LETTER
DATED 06-09-89
HASKELL
LABORATORIES |
E
I DUPONT DE NEMOURS & CO
FLUOROCARBON 152A (75-37-6)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
PHARMACO KINETICS
SUBCHRONIC TOXICITY
ORAL
RABBITS
DERMAL |
75-37-6
75-45-6
75-69-4
75-71-8
76-13-1
76-14-2
76-15-3 |
NTIS/OTS0520425
EPA/OTS;
Doc #86-890000319 |
1989
-
A TABLE OF ACUTE ORAL, AND DERMAL LD50'S
AND INHALATION LD50'S FOR FC-11, 12, 22, 113, 114,
115, AND 152A WITH ATTACHMENTS AND COVER LETTER DATED
06-09-89
HASKELL
LABORATORIES |
E
I DUPONT DE NEMOURS & CO
FLUOROCARBON 152A (75-68-3)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
PHARMACO KINETICS
SUBCHRONIC TOXICITY
ORAL
RABBITS
DERMAL |
75-37-6
75-45-6
75-69-4
75-71-8
76-13-1
76-14-2
76-15-3 |
NTIS/OTS0520985
EPA/OTS;
Doc #86-890000870 |
1989
-
CARDIAC SENSITIZATION WITH ATTACHMENTS
AND COVER SHEET DATED 06-12-89
HASKELL
LABORATORIES
|
E
I DUPONT DE NEMOURS & CO
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
INHALATION |
74-98-6
75-01-4
75-37-6
75-45-6
75-68-3
76-15-3
115-10-6
127-18-4 |
NTIS/OTS0520943
EPA/OTS;
Doc #86-890000827 |
1989
-
CARDIAC SENSITIZATION WITH ATTACHMENT
AND COVER SHEET DATED 06-12-89
HASKELL
LABORATORIES
|
E
I DUPONT DE NEMOURS & CO
1,1-DIFLUOROETHANE (75-37-6)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
INHALATION |
74-98-6
75-01-4
75-37-6
75-45-6
75-68-3
76-15-3
115-10-6
127-18-4 |
NTIS/OTS0520982
EPA/OTS;
Doc #86-890000867 |
1989
-
CARDIAC SENSITIZATION WITH ATTACHMENTS
AND COVER SHEET DATED 06-12-89
HASKELL
LABORATORIES |
E
I DUPONT DE NEMOURS & CO
1-CHLORO-1,1-DIFLUOROETHANE (75-68-3)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
INHALATION |
74-98-6
75-01-4
75-37-6
75-45-6
75-68-3
76-15-3
115-10-6
127-18-4 |
NTIS/OTS0516797
EPA/OTS;
Doc #86-890000263 |
1989
- HEALTH AND SAFETY STUDIES FOR 19 CHEMICALS WITH COVER LETTER
DATED 06-02-89
HUNTINGDON
RES CTR |
UNION
CARBIDE CORP
DIMETHYLFORMAMIDE (68-12-2)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
RABBITS
DERMAL
INHALATION
ENVIRONMENTAL FATE
BIODEGRADATION
PRIMARY DERMAL IRRITATION
GUINEA PIGS
PRIMARY DERMAL SENSITIZATION
PRIMARY EYE IRRITATION
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MICE
ENVIRONMENTAL EFFECTS
FISH-FRESHWATER
INVERTEBRATES
SUBCHRONIC TOXICITY
BIOCHEMISTRY
DOGS
PARENTERAL
INTRAVENOUS
INTRAPERITONEAL
PHARMACO KINETICS
HUMANS
GENOTOXICITY
GENE MUTATIONS
HAMSTERS
IN VITRO
DNA EFFECTS
CHROMOSOMAL EFFECTS
MICROBIAL FUNCTION TESTS
BACTERIA
CHRONIC TOXICITY |
68-12-2
75-45-6
76-13-1
80-62-6
95-14-7
96-45-7
102-71-6
107-98-2
108-88-3
111-42-2
111-76-2
111-77-3
111-90-0
124-16-3
140-88-5
141-43-5
25498-49-1
29385-43-1
34590-94-8 |
NTIS/OTS0521033
EPA/OTS;
Doc #86-890001417 |
1989
- HEALTH HAZARD EVALUATION REPORT CONCERNING REFRIGERATION
WORKERS IN SALT LAKE CITY WITH COVER LETTER DATED 07-28-89
|
RACON INC
CHLOROPENTAFLUOROETHANE (76-15-3)
HEALTH EFFECTS
EPIDEMIOLOGY |
75-45-6
75-69-4 |
NTIS/OTS0520616
EPA/OTS;
Doc #86-890000577S |
1989
- SUBACUTE INHALATION TOXICITY
STUDY IN ALBINO RATS WITH ATTACHMENTS AND COVER LETTER DATED
06-12-89 (SANITIZED)
|
CONFIDENTIAL
CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION |
75-43-4
|
NTIS/OTS0000602-1
EPA/OTS;
Doc #FYI-OTS-0988-0602 |
1988
- SIMULATED CONSUMER EXPOSURE TO PROPELLANT
HCFC 22 (CHLORODIFLUOROMETHANE) IN AEROSOL PERSONAL
PRODUCTS WITH COVER LETTER DATED 09-13-88
|
LEVER
BROS CO
CHLORODIFLUOROMETHANE
HEALTH EFFECTS
INDUSTRIAL HYGIENE |
75-45-6
|
NTIS/OTS0000602-2
EPA/OTS;
Doc #FYI-OTS-0688-0602D |
1988
- ARCTON 22: PHARMACOKINETICS IN THE PREGNANT
FEMALE RAT FOLLOWING INHALATION EXPOSURE & MODEL
PREDICTIONS OF BLOOD CONCENTRATION & BODY BURDEN OF FC22
IN HUMANS & RATS WITH LETTER |
IMPERIAL
CHEMICAL INDUS
ARCTON 22
HEALTH EFFECTS
PHARMACO KINETICS
MAMMALS
RATS
INHALATION |
75-45-6
|
NTIS/OTS0000111-0
EPA/OTS;
Doc #FYI-OTS-0481-0111
|
1985
-
CHLOROFLUOROCARBON 22(CFC 22-CHLORODIFLUROMETHANE)
1C1
LTD CTR TOXICOL LAB
|
ICI
AMERS INC
METHANE, CHLORODIFLUORO-
HEALTH EFFECTS
CHRONIC TOXICITY
CARCINOGENICITY
MAMMALS
RATS
INHALATION
MICE |
75-45-6
|
NTIS/OTS0205948
EPA/OTS;
Doc #878211462 |
1982
- MUTAGENIC ASSAY OF T-1716AC AEROSOL WITH AND WITHOUT METABOLIC
ACTIVATION WITH COVER LETTER
INDUS
BIO TEST LABS INC
|
The mutagenicity
of 1,1,1-trichloroethane (TCE) was evaluated in Salmonella tester
strain TA100 (Ames Test, desiccator assay variation), both in
the presence and absence of added metabolic activation by Aroclor-induced
rat liver S9 fraction. TCE was tested for mutagenicity at dose
levels of 0.4, 1.90 and 8.92 gm/desiccator. No rationale for
selection of dose levels used was reported. TCE caused a positive
response in strain TA100 with metabolic activation at 1.90 ml/desiccator.
The mutagenicity of T-1716AC (60% TCE, 30% monochlorodifluoromethane,
and <2% 1,4-dioxane) was evaluated in the same strain under
the same conditions as abov e. Although the dose levels were
not reported, the authors did state that the mixture was discharged
for time periods of 0.5, 1.0 and 5.0 seconds. T-1716AC did not
cause a reproducible positive response in TA100 at any of the
exposure periods. |
Keywords:
MINNESOTA MINING & MFG CO
1,1,1-TRICHLOROETHANE (71-55-6)
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
CAS Registry
Numbers:
71-55-6
75-45-6
123-91-1 |
NTIS/OTS0527479
EPA/OTS;
Doc #40-8023083 |
1980
- ACQUISITION AND CHEMICAL ANALYSIS
OF MOTHER'S MILK FOR SELECTED TOXIC SUBSTANCES (DECEMBER
1980)
RESEARCH TRIANGLE INST
|
Samples
of mother's milk were collected from persons in 5 cities and
analyzed by gas chromatography and spectrophotometry for volatile
and semivolatile organics. In the volatile fraction, 26 halogenated
hydrocarbons, 17 aldehydes, 20 ketones, 11 alcohols, 2 acids,
3 ethers, 1 epoxide, 14 furans, 26 other oxygenated compounds,
4 sulfur-containing compounds, 7 nitrogen-containing compounds,
13 alkanes, 12 alkenes, 7 alkynes, 11 cyclic hydrocarbons, and
15 aromatics were found, including major peaks for hexanol,
limonene, dichlorobenzene, and some esters. Semivolatile compounds
of interest that were identified in the samples were polychlorinated
biphenyls and DDE. Polychlorinated naphthalenes, polybrominated
biphenyls, chlorinated phenols, and other compounds were specifically
sought but not detected (limit of detection was about 20-100
ng/mL mild). The prevalent halogenated
compounds in ambient air and water near 2 New Jersey and 3 Louisiana
ci |
