Many modern pharmaceuticals (e.g. Prozac, Paxil) contain “organofluorines.” An organofluorine is a chemical compound that contains both carbon and fluorine. The fact, however, that a pharmaceutical is made with an organofluorine does not mean that it will increase your exposure to fluoride. This is because the fluorine in the drug forms a very strong bond with the carbon and this bond resists metabolizing into fluoride ion. It is generally believed, therefore, that most organofluorine drugs do not contribute to daily fluoride exposure.
There are some organofluorine drugs, however, that do metabolize into fluoride. This is evident by studies finding elevated levels of fluoride showing up in the urine or blood following use of the drug. Because organofluorine drugs contain high quantities of fluorine, any drug that metabolizes into fluoride will likely be a very large source of daily exposure. Drugs that are known to break down into fluoride ion include: fluorinated anesthetics, Cipro, Niflumic acid, Flecainide, and Voriconazole. It is possible, and indeed likely, that other drugs do so as well, but have not yet been discovered.
The following are a list of studies documenting inorganic fluoride exposure from the use of organofluorine drugs:
Anesthetics (Isoflurane, Sevoflurane)
Hoemberg M, et al. (2012). Plasma fluoride concentrations during prolonged administration of isoflurane to a pediatric patient requiring renal replacement therapy. Paediatric Anaesthia 22(4):412-3.
Oc B, et al. (2012). The effects of sevoflurane anesthesia and cardiopulmonary bypass on renal function in cyanotic and acyanotic children undergoing cardiac surgery. Renal Failure 34(2):135-41.
Pradhan KM, et al. (1995). Safety of ciprofloxacin therapy in children: magnetic resonance images, body fluid levels of fluoride and linear growth. Acta Paediatrica 84(5):555-60.
Rimoli CN, et al. (1991). Relationship between serum concentrations of flecainide and fluoride in humans. Boll. Chim. Farmaceutico 130(7):279-82.
Gras-Champel V, et al. (2003). [Chronic fluorine intoxication during prolonged treatment with niflumic acid]. [Article in French] Presse Med. 2003 Jun 7;32(20):933.
Welsch M, et al. (1990). [Iatrogenic fluorosis. 2 cases]. [Article in French] Therapie. 45(5):419-22.
Meunier PJ, et al. (1980). Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis? Clin Orthop Relat Res. 148:304-9.
Prost A, et al. (1978). [Fluorine osteosis caused by a very long-term niflumic acid treatment in 2 cases of rheumatoid arthritis]. [Article in French] Rev Rhum Mal Osteoartic. 45(12):707-16.
Wermers RA, et al. (2011). Fluoride excess and periostitis in transplant patients receiving long-term voriconazole therapy. Clinical Infectious Diseases 52(5):604-11.
Chen L, Milligan ME. (2011). Medication-induced periostitis in lung transplant patients: periostitis deformans revisited. Skeletal Radiology 40:143-48.
Fruit Juices May Foster Fluorosis in Children
Now even fruit juices - those "healthy" alternative beverages for your children - may cause a not-so-healthy response in their teeth. A recent study shows that too much fruit juice could damage the enamel on your children's teeth, reports the Academy of General Dentistry, an international organization of 34,000 general dentists.
Tooth Much of a Good Thing?
You think a wholesome act like Brushing teeth is free of Controversy? Wrong. A Connecticut dental researcher is warning parents that exposing their children's baby teeth to too much fluoride can lead to increased risk of enamel fluorosis once the permanent teeth erupt. With enamel fluorosis, the natural ceramic cover of the
Tea May Contain More Fluoride Than Once Thought, Research Shows
Black tea, a Southern staple and the world's most consumed beverage, may contain higher concentrations of fluoride than previously thought, which could pose problems for the heaviest tea drinkers, Medical College of Georgia researchers say. "The additional fluoride from drinking two to four cups of tea a day won't harm anyone;
Exposure Pathways Linked to Skeletal Fluorosis
Excessive fluoride exposure from any source -- and from all sources combined -- can cause skeletal fluorosis. Some exposure pathways , however, have been specifically identified as placing individuals at risk of skeletal fluorosis. These exposure pathways include: Fluoridated Water for Kidney Patients Excessive Tea Consumption High-Fluoride Well Water Industrial Fluoride Exposure Fluorinated Pharmaceuticals (Voriconazole
Naturally Occurring Levels of Fluoride in Fresh Food
Over the past 100 years, the levels of fluoride in foods purchased at the grocery store have increased. The reasons for this increase include: (1) the mass fluoridation of water supplies in some countries, (2) the introduction of fluoride-based pesticides, (3) the use of mechanical deboning processes, and, perhaps, (4)
Fluoride Content of Bottled Water
As with other fresh water supplies (e.g., spring water, lake water, river water), bottled waters have low levels of fluoride. Fresh surface water contains an average of just 0.05 ppm. To put this in perspective, artificially fluoridated water (using industrial-grade fluoride chemicals) contains 0.7 to 1.2 ppm fluoride, which is 14 to
FAN's Grocery Store Guide: 7 Ways to Avoid Fluoride in Beverages and Food
How do you know which beverages and foods at the grocery store are most likely to contain elevated fluoride, and which of these products are most important to avoid? To answer these questions, FAN has produced the following "general rules." The more you remember these rules when you shop, the more you will reduce your fluoride intake.
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