"When
bone turnover occurs, the potential exists for immune system
cells and stem cells to be exposed to concentrations of fluoride
in the interstitial fluids of bone that are higher than would
be found in serum."
SOURCE: National Research Council.
(2006). Fluoride
in Drinking Water: A Scientific Review of EPA's Standards.
National Academies Press, Washington D.C.
p 258.
"[P]atients who live in either an
artificially fluoridated community or a community where the
drinking water naturally contains fluoride at 4 mg/L have
all accumulated fluoride in their skeletal systems and potentially
have very high fluoride concentrations in their bones. The
bone marrow is where immune cells develop and that could affect
humoral immunity and the production of antibodies to foreign
chemicals.”
SOURCE: National Research Council.
(2006). Fluoride
in Drinking Water: A Scientific Review of EPA's Standards.
National Academies Press, Washington D.C.
p 249.
“There is no question that fluoride
can affect the cells involved in providing immune responses.
The question is what proportion, if any, of the population
consuming drinking water containing fluoride at 4.0 mg/L on
a regular basis will have their immune systems compromised?
Not a single epidemiologic study has investigated whether
fluoride in the drinking water at 4 mg/L is associated with
changes in immune function. Nor has any
study examined whether a person with an immunodeficiency disease
can tolerate fluoride ingestion from drinking water.”
SOURCE: National Research Council.
(2006). Fluoride
in Drinking Water: A Scientific Review of EPA's Standards.
National Academies Press, Washington D.C.
p 250.
"From an immunologic standpoint, individuals
who are immunocompromised (e.g., AIDS, transplant, and bone-marrow-replacement
patients) could be at greater risk of the immunologic effects
of fluoride.”
SOURCE: National Research Council.
(2006). Fluoride
in Drinking Water: A Scientific Review of EPA's Standards.
National Academies Press, Washington D.C.
p 258.
“It is paramount that careful biochemical
studies be conducted to determine what fluoride concentrations
occur in the bone and surrounding interstitial fluids from
exposure to fluoride in drinking water at up to 4 mg/L, because
bone marrow is the source of the progenitors that produce
the immune system cells.”
SOURCE: National Research Council.
(2006). Fluoride
in Drinking Water: A Scientific Review of EPA's Standards.
National Academies Press, Washington D.C.
p 259.
