Fluoride & Bone Remodeling

"We found that fluoride treatment increased bone turnover and bone mass in rabbits."
SOURCE: Turner CH, et al. (1997). Fluoride treatment increased serum IGF-1, bone turnover, and bone mass, but not bone strength, in rabbts. Calcified Tissue International 61: 77-83.

"NaF increased bone remodeling by 27% but this difference did not reach statistical significance."
SOURCE: Lafage MH, et al. (1995). Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs: a one year study. Journal of Clinical Investigations 95: 2127-2133.

"The rate of remodeling was increased in cortical bone from pigs receiving F due to an increased activation of new remodeling."
SOURCE: Kragstrup J, et al. (1989). Effects of fluoride on cortical bone remodeling in the growing domestic pig. Bone 10:421-424.

"The fractures may be a consequence of a fluoride-induced stimulation of bone remodeling."
SOURCE: Schnitzler CM, Solomon L. (1985). Trabecular stress fractures during fluoride therapy for osteoporosis. Skeletal Radioliology 14:276-9.

"The effect of fluoride on bone appears to be one of increased turnover with matrix formation exceeding resorption."
SOURCE: Riggins RS, et al. (1974). The effects of sodium fluoride on bone breaking strength. Calcified Tissue Research 14: 283-289.

"The bone from birds fed fluoride appeared to be in a state of accelerated-remodeling."
SOURCE: Chan MM, et al. (1973). Effect of fluoride on bone formation and strength in Japanese quail. Journal of Nutrition 103: 1431-1440.

"The accelerated remodeling of the cortex indicated that normal bone which acquired too high a fluoride content, did not survive the usual length of time."
SOURCE: Johnson LC. (1965). Histogenesis and mechanisms in the development of osteofluorosis. In: H.C.Hodge and F.A.Smith, eds : Fluorine chemistry, Vol. 4. New York, N.Y., Academic press (1965) 424-441.