Note from FAN: This letter discusses the meeting of Manhattan Project scientists in 1943, where they agreed upon the need for a secret wartime conference to discuss the "toxicity of fluorine compounds...with the view to orienting those concerned with the specific problems which may arise."

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29 September 1943

SUBJECT: Report on Meeting of 31 August 1943 for discussion of Toxicology Program.

On 31 August a meeting was held to discuss the allocation of a portion of the experimental program involving the study of the toxicologic effect of various special materials. Present at the meeting were: Dr. Col. Ruhoff, Major Hadlock, Lt. Sturgie (Special Materials), Dr. Wensel, Dr. Stone, Dr. Tannenbaum (Chicago Project), Dr. Hodge (Rochester Project), Dr. Warren, Major Friedell, Capt. (Medical Section).

It was decided that a conference on the toxicity of fluorine compounds should be held with the view to orienting those concerned with the specific problems which may arise. It was recommended that a program be arranged by the Public Health Service since some of their members have more exhaustive studies into the biological effects of fluorine and its compounds. The tentative arrangements met with approval of Lt. Col. Ruhoff, and it was contemplated that those companies actively engaged in the production of F, F2, and fluorides be invited. The meeting was also to be attended by representatives of the Manhattan District but their association with the District would be concealed by appropriate measures.

Dr. Tannenbaum and Dr. Hodge reviewed the data which they have accumulated on experimental feeding and ingestion of the various T (Uranium) compounds in rats and mice and in general the following results were obtained: It was reported by Dr. Hodge that T nitrate fed by mouth in large enough quantities can cause the death of rats weighing approximately 100 grams. TO2 in similar quantities produced no demonstrable effect on ingestion, and TF4 in large quantities produced some interference with growth but no deaths were encountered. Specifically, the infromation was presented in the following manner:

TNO3 .5% of diet (50 millig./day) to rats -- same growth as controls.

1% of diet (100 millig./day) to rats -- gave slightly depressed growth rates as compared to normal.

(Unsigned)

cc: Lt. Col. Ruhoff
Dr. R.S. Stone

Note from FAN: This is the list of attendees to the Manhattan Project's fluoride conference. As noted in the document above, many of the attendees were representatives of "companies actively engaged in the production of F, F2, and fluorides" (e.g. DuPont, Kellex, ALCOA, Harshaw, and Mallinckrodt). Along with industry representatives, the conference was attended by scientists from the Manhattan Project, scientists from industry-friendly laboratories (e.g. Kettering Institute), and, conspicuously, three of the lead dental researchers of the day - David Ast, B.S. Bibby, and S.B. Finn. It was just over one year later when the first US fluoridation experiments began, and David Ast was to lead one of them (Newburgh/Kingston, New York). According to the minutes of the conference, "tests are being planned in which fluorine is to be introduced in municipal water supplies. The evidence seemed to indicate that teeth are definitely improved when some fluorine is present." (See photocopy of the minutes)

The Manhattan Project's interest in fluoridation was not known at the time of the experiments, indeed it wasn't known until some 50 years later. In the late 1990s, David Ast was questioned about his participation in the conference. Ast claimed to have no knowledge of it, and denied the fact that he was in attendance as the document below clearly shows (see Griffiths & Bryson, 1997).

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15 january 1944

Subject: Conference on Fluoride Metabolism 6 January 1944

MEMORANDUM to Major H.L. Friedell, U.S. Engineer Office, Knoxville, Tennessee

1. The following persons attended the above mentioned conference. The organization to which they are attached is indicated: